DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and kcnh4b

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_017213998.1	Gene:	kcnh4b / 567442	ZFINID:	ZDB-GENE-121214-54	Length:	1193	Species:	Danio rerio

Alignment Length:	720	Identity:	178/720 - (24%)
Similarity:	313/720 - (43%)	Gaps:	137/720 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 DTQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFS 239
            :|.:|.|:.....|.:   |.|     .:::|..|..||...|:..:||            .:|:
Zfish   135 ETHEKSHHSSKTDDKA---NSR-----TTEKSHISKARRRGHAMIYQLT------------SQFT 179

  Fly   240 NTTNTD-KIGKGC---PAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAI-----VSLAVLY 295
            ..:..| |:.:..   |::.:..::: ::.|..:....||...|   :.|:.:     |::.|.|
Zfish   180 RDSKNDVKLSRDMFEKPSLPEYKVAA-VQKSRFILLHYSVSKAL---WDWMILLATFYVAVTVPY 240

  Fly   296 NIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFH 359
            |:.|.....|     ::|.......|...:.:::||.:::....::.| |.:|.:...:..||..
Zfish   241 NVCFTAYSDV-----ETAGRSTIVSDIAVEMLFILDIILNFRTTYVSQSGQVVYEPRSICLHYAT 300

  Fly   360 TKGW-YLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNA 423
            |  | ::|:::.||.||.|.:  ..|.:||.    .:::..||||:.||.:..||..
Zfish   301 T--WFFVDLVAALPFDLLYAF--NITVTSLV----HLLKTVRLLRLLRLLQKLDRYS-------- 349

  Fly   424 FRICKVVLAIL-----VLIHWNACMYFAI-----------SYEIGFSSDSWVYNLNGTR------ 466
             :...:||.:|     :|.||.||:::.|           :::||     |::.| |.|
Zfish   350 -QYSAMVLTLLMSMFALLAHWMACIWYIIGRKEMETNASGAWDIG-----WLHEL-GKRLDKPYM 407

  Fly   467 NNT-----LQRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMI 525
            |:|     ::..||.|.|::..:||::|......| |.|.:|.|...|.|.|:.|.:.||:.::|
Zfish   408 NSTFGGPSVRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSVCTMLIGALMHAVVFGNVTAII 472

  Fly   526 SNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEI 590
            ..|...|..:..||..:|.::...|:..:|:.|::.:|..|||.:..:|...:|...||:|:|:|
Zfish   473 QRMYSRRSLYHTRMKDLKDFIRVHRLPQQLKQRMLEYFQTTWSVNNGIDVNELLHDFPDELRADI 537

  Fly   591 AIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDD 655
            |:.::.|.| |:.:|.....|.|.:|.|.:|....:||:|:.|:||..:..|.|..|.|.|:.|:
Zfish   538 AMHLNKDIL-QLPVFEAASRGCLRSLSLHIKTSFCTPGEYLIRQGDALQANYFVCSGSLEVLKDN 601

  Fly   656 GITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTL 720
              .|||.||.|.:.|.    ::.|.....:..|:|::|.|.||..:..:.|.:.|..|||..:..
Zfish   602 --MVLAILGRGDLIGS----DLPGQNHVIKTNADVKALTYCDLQYIGVKGLSDVLELYPEYANIF 660

  Fly   721 T---QRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAE----YTASQ 778
            |   .|......::|...||.:.|              ..:|.||....:.....:    :..|.
Zfish   661 TIDIHRNLTYNLREGSETEQNYPD--------------FSVSTENKRPSVVEKADDPDKYFHVSS 711

  Fly   779 AKIKQRLAKLEMNGGP----------GTWRLECEPQSRARSG-RLYSLQPKRRPRSR-------P 825
            |....|...|...|.|          |...::.......||. |.:|..|..:|.|:       |
Zfish   712 ASSTCRNLLLPNLGSPVRRTSLGNLLGEELMQFNALRHCRSPVRGWSPNPSPKPPSKVQKQTQQP 776

  Fly   826 DATAK 830
            .:|.|
Zfish   777 SSTPK 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	64/249 (26%)
		Ion_trans_2	<477..527	CDD:285168	17/50 (34%)
		Crp	598..>722	CDD:223736	40/126 (32%)
		CAP_ED	604..717	CDD:237999	37/112 (33%)
		CLZ	720..791	CDD:293134	13/77 (17%)
kcnh4b	XP_017213998.1	PAS_9	29..135	CDD:290162	178/720 (25%)
		PAS	42..133	CDD:238075
		Ion_trans	261..480	CDD:278921	64/241 (27%)
		Ion_trans_2	<420..474	CDD:285168	19/53 (36%)
		Crp	547..>668	CDD:223736	40/126 (32%)
		CAP_ED	550..660	CDD:237999	37/115 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840