Protein Alignment CngA and hcn4

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_686078.4
• Gene: hcn4 / 557843
• ZFINID: ZDB-GENE-050420-360
• Length: 1140
• Species: Danio rerio
• Alignment Length: 520
• Identity: 130/520 - (25%)
• Similarity: 243/520 - (46%)
• Gaps: 67/520 - (12%)

  Fly   275 VDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEG 339
            :.|.....:.|...:.|.::.|:|.:.....|::...:.|  |...:.:.|..:|:|.:::...|
Zfish   216 IHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDEHTPP--WIVFNVVSDTFFLMDLVLNFRTG 278

  Fly   340 FL--DQGLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPV------- 394
            .:  |...::.|..:::..|.  :.|: :|.:|.:|.|..::.......|..|.....
Zfish   279 IVKEDNAEIILDPQQIKIKYL--RSWFVVDFISSIPVDYIFLIVETRIDSDFYKTARALRIVRFT 341

  Fly   395 -IVRLNRLLRINRL------WE-----WFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAI 447
             |:.|.||||::||      ||     .:|......      ||..::..:|:|.||:.|:.|.:
Zfish   342 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAMV------RIVNLIGMMLLLCHWDGCLQFLV 400

  Fly   448 SYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG---ETPTPENDVEYLFVVADFLA 509
            .....|.:|.||.. |...|:|..:||.|:.:.:...:..||   ..|....||  ...:...:.
Zfish   401 PMLQDFPADCWVAK-NKMVNDTWGQQYSYALFKAMSHMLCIGYGMYPPVGMTDV--WLTILSMIV 462

  Fly   510 GVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALD 574
            |...:|..||:..::|.:::.:|.::|.:...|:|||:|.::..::..|:..::.:.: |....|
Zfish   463 GATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRY-QGKMFD 526

  Fly   575 EERVLAALPDKLKAEIAIQVHMDTLKQVR---IFHDTEPGLLEALVLKLKLQVFSPGDYICRKGD 636
            ||.:|..|.:.|:.||   ::.:..|.|.   :|.:.:|..:.:::.||:.:||.|||||.|:|.
Zfish   527 EESILGELNEPLREEI---INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGT 588

  Fly   637 VGKEMYIVKRGKLSVV--GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLF 699
            :||:||.::.|.:||:  |:..    ..|..||.|||:.:|      |..||||:||:..|..|:
Zfish   589 IGKKMYFIQHGVVSVLTKGNKE----TKLSDGSYFGEICLL------TRGRRTASVRADTYCRLY 643

  Fly   700 CLAKRDLWETLSDYPEAR----STLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSV 760
            .|:..:..|.|.:||..|    :....|..::.:|:.:|..::      .||...|.:...|..:
Zfish   644 SLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILQHKV------QHDLNSGVLNYQESEI 702

  Fly   761  760
            Zfish   703  702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	60/271 (22%)
		CAP_ED	604..717	CDD:237999	42/114 (37%)
		CLZ	720..790	CDD:465160	7/41 (17%)
hcn4	XP_686078.4	Ion_trans_N	179..221	CDD:400630	1/4 (25%)
		PLN03192	214..>720	CDD:215625	130/520 (25%)
		CAP_ED	556..664	CDD:237999	43/117 (37%)
		Herpes_BLLF1	<797..1139	CDD:282904