Protein Alignment CngA and kcnh5a

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001263209.1
• Gene: kcnh5a / 556304
• ZFINID: ZDB-GENE-061106-2
• Length: 1093
• Species: Danio rerio
• Alignment Length: 606
• Identity: 151/606 - (24%)
• Similarity: 253/606 - (41%)
• Gaps: 138/606 - (22%)

  Fly   278 TLQSHYRWLAIV-----SLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMH 337
            |.::.:.|:.::     ::.|.||:.|.         .|.....|..||.:.|.|:|:|.:::.|
Zfish   212 TFKTTWDWVILILTFYTAIMVPYNVSFK---------TKQNNLVWLVLDSVVDVIFLVDIVLNFH 267

  Fly   338 EGFLDQ-GLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDL---------------AYIWWPPET- 384
            ..|:.. |.::.|...:|.:|..|  |: :|:||.||.|:               :.:...|..
Zfish   268 TTFVGPGGEVISDPKLIRMNYLKT--WFVIDLLSCLPYDIINAFENVDEDTFVDSSAVGHLPSAG 330

  Fly   385 ----------------CSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAI 433
                            .|||:....|:    ||||:.|:....|         :.......||.:
Zfish   331 HSPRNATRAEDSVLPGLSSLFSSLKVV----RLLRLGRVARKLD---------HYLEYGAAVLVL 382

  Fly   434 LVLI-----HWNACMYFAI-SYEI------GFSSDSWVYNL-------------------NGTRN 467
            ||.:     ||.||::::| .||:      ...:|||:|.|                   .|...
Zfish   383 LVCVFGLVAHWLACIWYSIGDYEVIDEATNSLKTDSWLYQLAISIGTPYRYNASGSGHWEGGPSK 447

  Fly   468 NTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVA 531
            :||   ||.|.|::..:||||| ....|..|.|.:|.||..:.|.|::|||.||:.::...|...
Zfish   448 HTL---YISSLYFTMTSLTTIGFGNIAPTTDGEKIFSVAMMMVGSLLYATIFGNVTTIFQQMYTN 509

  Fly   532 RVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHM 596
            ...:...::.|:.::...:|...|..||:.:...||:.:..:|.|:||:..|..::|:|.:.::.
Zfish   510 TNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWAMTKGIDTEKVLSICPKDMRADICVHLNR 574

  Fly   597 DTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLA 661
            ....:...|.....|.|.:|.::.:....:|||.|...|:....:..|..|.|.|:.||  .|:|
Zfish   575 QVFNEHPAFRLASDGCLRSLAVEFQTTHCAPGDLIFHAGESVDTLCFVVSGSLEVIQDD--EVIA 637

  Fly   662 TLGAGSVFGEV----SVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQ 722
            .||.|.|||:|    |.|..|        .||||:|.|.||..:.:..|.:.|..|....::.::
Zfish   638 ILGKGDVFGDVFWKESSLAHA--------CANVRALTYCDLHVIRRDALLKVLEFYTAFANSFSR 694

  Fly   723 R---GCQL-----LRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQA 779
            .   .|.|     .||...:.::   :.:|.|...|   ..|.:.|::...:|.:
Zfish   695 NLILTCNLRKRIVFRKIADVKKE---EEERRHQKNE---VTLSIPVDHPVRKLFQ---------- 743

  Fly   780 KIKQRLAKLEMNGGPGTWRLE 800
            |.||:  |.....||..:.||
Zfish   744 KFKQQ--KEMRTQGPSQYDLE 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	79/317 (25%)
		CAP_ED	604..717	CDD:237999	38/116 (33%)
		CLZ	720..790	CDD:465160	14/77 (18%)
kcnh5a	NP_001263209.1	PAS_9	39..132	CDD:463873
		PLN03192	217..>648	CDD:215625	117/459 (25%)
		cyc_nuc_ocin	<606..705	CDD:274839	35/108 (32%)