DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and Cngb3

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001258167.1	Gene:	Cngb3 / 500418	RGDID:	1565364	Length:	690	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	181/618 - (29%)
Similarity:	291/618 - (47%)	Gaps:	94/618 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 TQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRP------------ 228
            |.:|.|   :..|:|..||..:..........|:.|..|:..:.|..|::.:|
  Rat    54 TVEKSH---SKEDNSTGENSLRGSTTNPDTECPAELTGTISEMEQTRTRKEKPASIKTKVFETSI 115

  Fly   229 --KPPDWFLEK----------FSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQS 281
              :..|..|..          |...|.|:  |:..|.:|   .||....|:.:..|..::...:.
  Rat   116 INEYTDAHLHNLVERMRERTAFYKRTLTE--GENSPELE---ASSHTATSTDISPRQEINSKPKE 175

  Fly   282 HYR------------------------------WLAIVSLAVLYNIIFVVGRAVFWEINKSAPAF 316
            |:.                              ||.:|::|..:|...:..|.||.........:
  Rat   176 HHHKLQRVPVKEYLRSMRLPRSIDSYTDRIYLLWLLLVTIAYNWNCWLLPVRLVFPCQTPDNRNY 240

  Fly   317 WYTLDYLCDFIYLLD-TLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWW 380
            |...|.:||.|||.| .|:.....|:..|.::.|:..|:|||..:..:.:||.|:||.::.||::
  Rat   241 WIITDIICDIIYLGDILLIQPRLQFVRGGEIIVDSNELKRHYRSSTKFQMDVASLLPFEVLYIFF 305

  Fly   381 PPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYF 445
            ....          |.|.||:|:....:|:....|:.......:||.:....:|.|:|.|||:|:
  Rat   306 GVNP----------IFRTNRILKYTSFFEFNHHLESIMDRAYVYRIIRTTGYLLFLLHINACVYY 360

  Fly   446 -AISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLA 509
             |..|| |..|..||||..|.:       |:..|||:..||.|||..|.|:...|.:|.:.:|.:
  Rat   361 WASDYE-GIGSTKWVYNGEGNK-------YLRCFYWAVRTLITIGGLPEPQTSFEIVFQLLNFFS 417

  Fly   510 GVLIFATIVGN----IGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQS 570
            ||.:|::::|.    ||:..:|.|    .|...||.:..||....:....:.||..|..|||...
  Rat   418 GVFVFSSLIGQMRDVIGAATANQN----NFHVCMDHIIAYMNKYSIPQSTQHRVRTWLEYTWHSQ 478

  Fly   571 GALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKG 635
            ..|||..:|..||..::..:||.::.:.:.:|.:|...:..::..|:|:||..::.|||::|:||
  Rat   479 RILDESNLLETLPTAMQLSVAIDINFNIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKG 543

  Fly   636 DVGKEMYIVKRGKLSVV-GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLF 699
            ::||||||:|.|::.|: |.||..||.||.||:||||:|:|...|   ||||||:|.:.|:::|.
  Rat   544 EIGKEMYIIKHGEVQVLGGPDGAQVLVTLKAGAVFGEISLLAKGG---GNRRTADVVAHGFANLL 605

  Fly   700 CLAKRDLWETLSDYPEARSTLTQRGCQLLRKDG 732
            .|.|:.|.|.|..||.::..|.::...||.:.|
  Rat   606 TLDKKTLQEILLHYPTSKKLLMKKAKVLLSQKG 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	70/225 (31%)
		Ion_trans_2	<477..527	CDD:285168	19/53 (36%)
		Crp	598..>722	CDD:223736	54/124 (44%)
		CAP_ED	604..717	CDD:237999	52/113 (46%)
		CLZ	720..791	CDD:293134	4/13 (31%)
Cngb3	NP_001258167.1	CAP_ED	512..620	CDD:237999	50/110 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850