Protein Alignment CngA and Cngb3

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001258167.1
• Gene: Cngb3 / 500418
• RGDID: 1565364
• Length: 690
• Species: Rattus norvegicus
• Alignment Length: 618
• Identity: 181/618 - (29%)
• Similarity: 291/618 - (47%)
• Gaps: 94/618 - (15%)

  Fly   176 TQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRP------------ 228
            |.:|.|   :..|:|..||..:..........|:.|..|:..:.|..|::.:|
  Rat    54 TVEKSH---SKEDNSTGENSLRGSTTNPDTECPAELTGTISEMEQTRTRKEKPASIKTKVFETSI 115

  Fly   229 --KPPDWFLEK----------FSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQS 281
              :..|..|..          |...|.|:  |:..|.:|   .||....|:.:..|..::...:.
  Rat   116 INEYTDAHLHNLVERMRERTAFYKRTLTE--GENSPELE---ASSHTATSTDISPRQEINSKPKE 175

  Fly   282 HYR------------------------------WLAIVSLAVLYNIIFVVGRAVFWEINKSAPAF 316
            |:.                              ||.:|::|..:|...:..|.||.........:
  Rat   176 HHHKLQRVPVKEYLRSMRLPRSIDSYTDRIYLLWLLLVTIAYNWNCWLLPVRLVFPCQTPDNRNY 240

  Fly   317 WYTLDYLCDFIYLLD-TLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWW 380
            |...|.:||.|||.| .|:.....|:..|.::.|:..|:|||..:..:.:||.|:||.::.||::
  Rat   241 WIITDIICDIIYLGDILLIQPRLQFVRGGEIIVDSNELKRHYRSSTKFQMDVASLLPFEVLYIFF 305

  Fly   381 PPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYF 445
            ....          |.|.||:|:....:|:....|:.......:||.:....:|.|:|.|||:|:
  Rat   306 GVNP----------IFRTNRILKYTSFFEFNHHLESIMDRAYVYRIIRTTGYLLFLLHINACVYY 360

  Fly   446 -AISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLA 509
             |..|| |..|..||||..|.:       |:..|||:..||.|||..|.|:...|.:|.:.:|.:
  Rat   361 WASDYE-GIGSTKWVYNGEGNK-------YLRCFYWAVRTLITIGGLPEPQTSFEIVFQLLNFFS 417

  Fly   510 GVLIFATIVGN----IGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQS 570
            ||.:|::::|.    ||:..:|.|    .|...||.:..||....:....:.||..|..|||...
  Rat   418 GVFVFSSLIGQMRDVIGAATANQN----NFHVCMDHIIAYMNKYSIPQSTQHRVRTWLEYTWHSQ 478

  Fly   571 GALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKG 635
            ..|||..:|..||..::..:||.::.:.:.:|.:|...:..::..|:|:||..::.|||::|:||
  Rat   479 RILDESNLLETLPTAMQLSVAIDINFNIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKG 543

  Fly   636 DVGKEMYIVKRGKLSVV-GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLF 699
            ::||||||:|.|::.|: |.||..||.||.||:||||:|:|...|   ||||||:|.:.|:::|.
  Rat   544 EIGKEMYIIKHGEVQVLGGPDGAQVLVTLKAGAVFGEISLLAKGG---GNRRTADVVAHGFANLL 605

  Fly   700 CLAKRDLWETLSDYPEARSTLTQRGCQLLRKDG 732
            .|.|:.|.|.|..||.::..|.::...||.:.|
  Rat   606 TLDKKTLQEILLHYPTSKKLLMKKAKVLLSQKG 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	79/282 (28%)
		CAP_ED	604..717	CDD:237999	52/113 (46%)
		CLZ	720..790	CDD:465160	4/13 (31%)
Cngb3	NP_001258167.1	PLN03192	198..>584	CDD:215625	133/407 (33%)
		CAP_ED	512..620	CDD:237999	50/110 (45%)