Protein Alignment CngA and for

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 947
• Identity: 176/947 - (18%)
• Similarity: 296/947 - (31%)
• Gaps: 339/947 - (35%)

  Fly    26 TESPKYGYNLSNRPMYRTTRLVGPASSAPAQLQLPCGSHQATLGV---APPPLEEISGGLFAPFA 87
            |:.|....| ||.|...||      ..||.:   |.....||:.|   ||||.:.:|...:|.:.
  Fly    12 TKRPAQNSN-SNAPHSSTT------VDAPPR---PADVDVATVPVATPAPPPQQPVSNLFYADYQ 66

  Fly    88 PTATITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDDVDEDD 152
            ...           |..:|          |.|:|                       |.|.|.|
  Fly    67 KLQ-----------PAIID----------RDWER-----------------------DRDTDTD- 86

  Fly   153 DDEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGRKL---IQEPSK---------- 204
                  :..|..|.:.:          :|.:|       ||..|::   ||.|::
  Fly    87 ------TRSEAKPPDIV----------EHIEP-------VEEQRQIHTQIQSPAEIQIQIPPTPP 128

  Fly   205 ------------RSKPSALRRTL----------QALRQRLTKRNRPK-----PPDWFLEKF---S 239
                        |...||..|.|          :|||:..:.:..|.     |.|..|...   :
  Fly   129 APSIQIQIQQRYRRHSSAEDRNLNTRRNDSNITEALRKAASMQQEPNANYQFPTDLGLVSIVNNN 193

  Fly   240 NTTNTDKIGKGCPAMEDAALSSEIRGSSV-------------LCNRLSVDPTLQSHYRWLAIVSL 291
            |.|||...|....:..::.:::.:.|..|             ..:.|.:.|...:|       |.
  Fly   194 NNTNTHPSGSNSGSNNNSNINNNLVGGIVTLPAAGGLIGLEHTASGLRLIPAPPTH-------SD 251

  Fly   292 AVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQGLLVRDAFRLRRH 356
            .:.:.:|:....:...::|:..                 .:|:|..|..|.|...     :|::.
  Fly   252 VLTHTLIYGTPPSGAQQLNQDP-----------------RSLLHQQELQLQQRYQ-----QLQQL 294

  Fly   357 YFHTKGWYLDVLSML------PTDLAYIWWPPETC-SSLYLPCPVIVRLNRLLRINRLWEWFDRT 414
            ...|:|.|....|.:      |.....:..|..|| |...|..|..:.|.:.::..|:   ...|
  Fly   295 QAQTQGLYTSQGSPVLYHQPSPGSSQPVAIPGATCHSPTQLQPPNTLNLQQQMQSLRI---SGCT 356

  Fly   415 ETATG-----------------------YPNAFRICKVVLAILVLIHWNACMYFAISYE------ 450
            .:.||                       .|...|..:::.|..:.|..   |..|:.::
  Fly   357 PSGTGGSATPSPVGLVDPNFIVSNYVAASPQEERFIQIIQAKELKIQE---MQRALQFKDNEIAE 418

  Fly   451 ------------------------IGFSSDSWVYNLNGTRNNT-----------LQRQYIYSFYW 480
                                    .|.:|.|......|:...|           .|||
  Fly   419 LKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKSGQNFQRQ------- 476

  Fly   481 STLTLTTIGETPTPENDVEYLFVVADF-------LAGVLIFATIVGNIGSMISNMNVARV-EFQN 537
                 ..:|.:..|:::...|.....|       .:..||.|.|:.|  ..:.|:::.:: |..:
  Fly   477 -----RALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDN--DFMKNLDLTQIREIVD 534

  Fly   538 RMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALD---EERVLAALPD-KLKAEIAI------ 592
            .|..|| |.|...:..|.:...|.:.    .:.|.::   |.:.|:.|.. |:..|:||
  Fly   535 CMYPVK-YPAKNLIIKEGDVGSIVYV----MEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQR 594

  Fly   593 --------------------------------QVHMDTLKQVRIFHDTEPGLLEALVLK----LK 621
                                            ..:.|.||.|.||.|    |.|..::|    |:
  Fly   595 TATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKD----LAEDTLIKISDVLE 655

  Fly   622 LQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGIT----VLATLGAGSVFGEVSVLEIAGNRT 682
            ...:..||||.|:|..|...:|:.:||:.|......|    .:..||.|..|||.::      :.
  Fly   656 ETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKAL------QG 714

  Fly   683 GNRRTANVRSLGYSDLFCLA--KRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQI----FAD 741
            .:.||||:.......:.||.  :....:.:|:..|.:......|....||   ::|:.    ..|
  Fly   715 DDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRK---INEEFRDINLTD 776

  Fly   742 SQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQ 778
            .:.:.....||..::||...|.:...:..|.:...||
  Fly   777 LRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQ 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	50/324 (15%)
		CAP_ED	604..717	CDD:237999	33/122 (27%)
		CLZ	720..790	CDD:465160	13/63 (21%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	6/49 (12%)
		CAP_ED	520..629	CDD:237999	17/113 (15%)
		CAP_ED	638..754	CDD:237999	33/125 (26%)
		STKc_cGK	783..1043	CDD:270724	8/31 (26%)