DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and kcnh6a

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_998002.1	Gene:	kcnh6a / 405763	ZFINID:	ZDB-GENE-040702-5	Length:	1186	Species:	Danio rerio

Alignment Length:	663	Identity:	157/663 - (23%)
Similarity:	274/663 - (41%)	Gaps:	145/663 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 KQHY--------QPN-----------ASDSSYVENGRKLIQE-------------PSKRSKPSA- 210
            |.|:        ||:           :.||......:.|||:             ||.|.:||.
Zfish   176 KDHFEGVVVDYLQPSHEEVALKDLQMSPDSCLKSETQALIQQTPSSCELSPPPSRPSDRLEPSGP 240

  Fly   211 ------LRRTLQALRQRLTKRNRPKPPD-WFLEKFSNTTNT-----------------------D 245
                  .|.::.:||:..:..:.....| |...|.||..:|                       |
Zfish   241 LLKHSHSRESMHSLRRASSLHDIDGMRDQWSDLKPSNLNSTSDSDLMRHRTIGRIPQVTISFGSD 305

  Fly   246 KIGKGCPAMEDAALSSEIR-------------------GSSVLCNRLSVDPTLQS----HYR--- 284
            ::....|...:....|:|:                   |:.||.......|.:..    ||.
Zfish   306 RLRPPSPTEIEIIAPSKIKDRSQNVSEKVTQVTQVLSLGADVLPEYKLQAPRIHKWTILHYSPFK 370

  Fly   285 --WLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLC----------DFIYLLDTLVHMH 337
              |..|:.|.|||..:|....|.|. :|:.......|..|.|          |.::::|.|::..
Zfish   371 AVWDWIILLLVLYTAVFTPYSAAFL-LNEQEDERRRTCGYTCNPLNVVDLVVDVMFIIDILINFR 434

  Fly   338 EGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIWW---PPETCSSLYLPCPVIVR 397
            ..:::.. .:|.:..|:.:|||  |||:| |:::.:|.||.....   .|:|.:.:.|     ::
Zfish   435 TTYVNHNDEVVSNPARIAQHYF--KGWFLIDIVAAIPFDLLIFRSGSDEPQTTTLIGL-----LK 492

  Fly   398 LNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAI-------SYEIGFSS 455
            ..||||:.|:....||............:|...|    :.||.||:::||       |..||...
Zfish   493 TARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL----IAHWLACIWYAIGNMERTSSARIGGMK 553

  Fly   456 DSWVYNL-----------NGTRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFL 508
            ..|:.||           |.....:::.:|:.:.|::..:||::| ...:|..:.|.:|.:...|
Zfish   554 IGWLDNLADQIGKQYNDSNSFSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNPEKIFSICVML 618

  Fly   509 AGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGAL 573
            .|.|::|:|.||:.::|..:......:..:|..||:::.|.::...|..|:..:|.:.|..:..:
Zfish   619 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPGGLRQRLEEYFQHAWPYTNGI 683

  Fly   574 DEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVG 638
            |...||...|:.|:|:|.:.::...|:..:.|.....|.|.||.::.:.....|||.:...|||.
Zfish   684 DMNAVLKGFPECLQADICLHLNRSLLQSCKAFRGASKGCLRALAMRFRTTHAPPGDTLVHSGDVL 748

  Fly   639 KEMYIVKRGKLSVVGDDGITVLATLGAGSVFGE-VSVLEIAGNRTGNRRTANVRSLGYSDLFCLA 702
            ..:|.:.||.:.::.||  .|:|.||...:||| :|:....|     :.:|:||:|.|.||..:.
Zfish   749 TALYFISRGSIEILRDD--VVVAILGKNDIFGEPISLYARPG-----KSSADVRALTYCDLHKIL 806

  Fly   703 KRDLWETLSDYPE 715
            :.||.|.|..||:
Zfish   807 RDDLLEVLDMYPD 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	61/253 (24%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	39/119 (33%)
		CAP_ED	604..717	CDD:237999	38/113 (34%)
		CLZ	720..791	CDD:293134
kcnh6a	NP_998002.1	PAS	29..132	CDD:238075
		PAS_9	29..130	CDD:290162
		Ion_trans_2	<583..637	CDD:285168	16/53 (30%)
		CAP_ED	714..821	CDD:237999	38/113 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578294
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840