DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and Kcnh4

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001074663.1	Gene:	Kcnh4 / 380728	MGIID:	2156184	Length:	1018	Species:	Mus musculus

Alignment Length:	668	Identity:	169/668 - (25%)
Similarity:	299/668 - (44%)	Gaps:	119/668 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 KRSKPSALRRTLQALR---QRLT----KRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSS 261
            :|...|.||.|.:..|   .|||    :|.:           |:......:.:..|::.:..::|
Mouse   158 RRGTSSRLRSTKRQNRTVLHRLTGHFGRRGQ-----------SSVKANSNLFEPKPSVPEYKVAS 211

  Fly   262 EIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTL--DYLC 324
             :.||..|....|:...:     |..::.||..|..:.|.....|...:.:.....:||  |...
Mouse   212 -VGGSRCLLLHYSIPKAV-----WDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAV 270

  Fly   325 DFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHTKGW-YLDVLSMLPTDLAYIWWPPETCSS 387
            :.:::||.:::....::.| |.::.....:..||..|  | ::|:::.||.||.|::  ..|.:|
Mouse   271 EMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLAT--WFFVDLIAALPFDLLYVF--NITVTS 331

  Fly   388 LYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAIL-----VLIHWNACMYFAI 447
            |.    .:::..||||:.||.:..:|....:.         |||.:|     :|.||.||:::.|
Mouse   332 LV----HLLKTVRLLRLLRLLQKLERYSQCSA---------VVLTLLMSVFALLAHWMACVWYVI 383

  Fly   448 S-----------YEIGFSSDSWVYNL---------NGTRNNTLQRQ-YIYSFYWSTLTLTTIGET 491
            .           ::||     |::.|         ||:.....:|. ||.:.|::..:||::|..
Mouse   384 GRREMEANDPLLWDIG-----WLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFG 443

  Fly   492 PTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHEL 555
            ....| |.|.:|.:...|.|.|:.|.:.||:.::|..|...|..:.:||..:|.::...|:...|
Mouse   444 NVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPL 508

  Fly   556 EARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKL 620
            :.|::.:|..||:.:..:|...:|...||:|:|:||:.::.:.| |:.:|.....|.|.||.|.:
Mouse   509 KQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHI 572

  Fly   621 KLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGN- 684
            |....:||:|:.|:||..:..|.|..|.|.|:.|:  .|||.||.|.:.| ..:.|: |...|:
Mouse   573 KTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDN--MVLAILGKGDLIG-ADIPEL-GQEPGSG 633

  Fly   685 -------RRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADS 742
                   :.:|:|::|.|..|..|:.|.|.|.|..|||..:..         :.||..:..|
Mouse   634 AGPSCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYAAAF---------RAGLPRDLTF--- 686

  Fly   743 QRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRA 807
                 ::..|.|...|...:.:.||::..:: |...:..|...:..|..||       .||.:.:
Mouse   687 -----NLRQGSENNGLGRFSRSPRLSQARSD-TLGSSSDKTLPSITETEGG-------TEPGAGS 738

  Fly   808 RSGR---LYSLQPKRRPR 822
            :..|   |.:|.| .|||
Mouse   739 KPRRPHLLPNLSP-ARPR 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	61/250 (24%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	44/131 (34%)
		CAP_ED	604..717	CDD:237999	42/120 (35%)
		CLZ	720..791	CDD:293134	11/70 (16%)
Kcnh4	NP_001074663.1	PAS_9	29..135	CDD:290162
		PAS	42..133	CDD:238075
		Ion_trans	244..486	CDD:278921	64/263 (24%)
		Ion_trans_2	<426..480	CDD:285168	17/53 (32%)
		CAP_ED	556..676	CDD:237999	42/123 (34%)
		bZIP	<864..902	CDD:304365
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840