DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and KCNH2

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_000229.1	Gene:	KCNH2 / 3757	HGNCID:	6251	Length:	1159	Species:	Homo sapiens

Alignment Length:	914	Identity:	207/914 - (22%)
Similarity:	342/914 - (37%)	Gaps:	225/914 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SPKYGYNLSNRPMYRTTRLVGPASSAPAQLQLPCGSHQATLGVAPPPLEEISGGLFAPFAPTATI 92
            ||.:..|....|    |..:.|..:...:|:||     |.|.:........|||.....||.|.:
Human   140 SPAHDTNHRGPP----TSWLAPGRAKTFRLKLP-----ALLALTARESSVRSGGAGGAGAPGAVV 195

  Fly    93 ----------TVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDD 147
                      :.|..|.....|:|..|..|                    |.||
Human   196 VDVDLTPAAPSSESLALDEVTAMDNHVAGL--------------------GPAE----------- 229

  Fly   148 VDEDDDDEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALR 212
                   |..|.|...:|..: |.....:.:.....|:||.||.     .|.:..|:.|..|..|
Human   230 -------ERRALVGPGSPPRS-APGQLPSPRAHSLNPDASGSSC-----SLARTRSRESCASVRR 281

  Fly   213 RT----LQALRQRLTKRNRPKPP--------------------DWFLEKFSNTTNTDKIG----- 248
            .:    ::|:|..:.    |.||                    |..|.::...:...:|.
Human   282 ASSADDIEAMRAGVL----PPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVD 342

  Fly   249 -KGCPAMEDAALSSEI--------------RGSSVLCNRLSVDP--TLQS---------HYR--- 284
             ||.|.:.......||              :.:.||.....|.|  .||:         ||.
Human   343 LKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407

  Fly   285 --WLAIVSLAVLYNIIFVVGRAVFW--EINKSAPAF--------WYTLDYLCDFIYLLDTLVHMH 337
              |..::.|.|:|..:|....|.|.  |..:..||.        ...:|.:.|.::::|.|::..
Human   408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 472

  Fly   338 EGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNR 400
            ..:::.. .:|....|:..|||  |||:| |:::.:|.||.......|....|       ::..|
Human   473 TTYVNANEEVVSHPGRIAVHYF--KGWFLIDMVAAIPFDLLIFGSGSEELIGL-------LKTAR 528

  Fly   401 LLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDS---WVYNL 462
            |||:.|:....||............:|...|    :.||.||:::||........||   |::||
Human   529 LLRLVRVARKLDRYSEYGAAVLFLLMCTFAL----IAHWLACIWYAIGNMEQPHMDSRIGWLHNL 589

  Fly   463 ----------NGTRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFAT 516
                      :|....:::.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:
Human   590 GDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYAS 654

  Fly   517 IVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAA 581
            |.||:.::|..:......:..:|..|::::.|.::.:.|..|:..:|.:.||.:..:|...||..
Human   655 IFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 719

  Fly   582 LPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKR 646
            .|:.|:|:|.:.::...|:..:.|.....|.|.||.:|.|.....|||.:...||:...:|.:.|
Human   720 FPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISR 784

  Fly   647 GKLSVVGDDGITVLATLGAGSVFGE-VSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETL 710
            |.:.::..|  .|:|.||...:||| :::....|...|     :||:|.|.||..:.:.||.|.|
Human   785 GSIEILRGD--VVVAILGKNDIFGEPLNLYARPGKSNG-----DVRALTYCDLHKIHRDDLLEVL 842

  Fly   711 SDYPE--------ARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDS-----IEGGI---EKLELS 759
            ..|||        ...|...|                 |:..:..|     :|||.   .|.:||
Human   843 DMYPEFSDHFWSSLEITFNLR-----------------DTNMIPGSPGSTELEGGFSRQRKRKLS 890

  Fly   760 VENLNMRLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRARSGRLYSLQPKRRPRSR 824
            ......:......|.:|.               |||  |....|.||.|.|..:...|...| |.
Human   891 FRRRTDKDTEQPGEVSAL---------------GPG--RAGAGPSSRGRPGGPWGESPSSGP-SS 937

  Fly   825 PDAT 828
            |:::
Human   938 PESS 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	58/243 (24%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	40/132 (30%)
		CAP_ED	604..717	CDD:237999	38/121 (31%)
		CLZ	720..791	CDD:293134	11/78 (14%)
KCNH2	NP_000229.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..314		19/92 (21%)
		Ion_trans	409..668	CDD:306908	66/271 (24%)
		Selectivity filter. /evidence=ECO:0000250	624..629		1/4 (25%)
		CAP_ED	742..853	CDD:237999	38/117 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..982		22/90 (24%)
		SSTK-IP	1012..1113	CDD:318128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1038
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1119..1159
		PAS_9	29..130	CDD:315989
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840