Protein Alignment CngA and KCNH2

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_047276304.1
• Gene: KCNH2 / 3757
• HGNCID: 6251
• Length: 1185
• Species: Homo sapiens
• Alignment Length: 914
• Identity: 208/914 - (22%)
• Similarity: 343/914 - (37%)
• Gaps: 225/914 - (24%)

  Fly    28 SPKYGYNLSNRPMYRTTRLVGPASSAPAQLQLPCGSHQATLGVAPPPLEEISGGLFAPFAPTATI 92
            ||.:..|....|    |..:.|..:...:|:||     |.|.:........|||.....||.|.:
Human   166 SPAHDTNHRGPP----TSWLAPGRAKTFRLKLP-----ALLALTARESSVRSGGAGGAGAPGAVV 221

  Fly    93 ----------TVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDD 147
                      :.|..|.....|:|..|..|                    |.||
Human   222 VDVDLTPAAPSSESLALDEVTAMDNHVAGL--------------------GPAE----------- 255

  Fly   148 VDEDDDDEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALR 212
                   |..|.|...:|..: |.....:.:.....|:||.||.     .|.:..|:.|..|..|
Human   256 -------ERRALVGPGSPPRS-APGQLPSPRAHSLNPDASGSSC-----SLARTRSRESCASVRR 307

  Fly   213 RT----LQALRQRLTKRNRPKPP--------------------DWFLEKFSNTTNTDKIG----- 248
            .:    ::|:|..:.    |.||                    |..|.::...:...:|.
Human   308 ASSADDIEAMRAGVL----PPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVD 368

  Fly   249 -KGCPAMEDAALSSEI--------------RGSSVLCNRLSVDP--TLQS---------HYR--- 284
             ||.|.:.......||              :.:.||.....|.|  .||:         ||.
Human   369 LKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 433

  Fly   285 --WLAIVSLAVLYNIIFVVGRAVFW--EINKSAPAF--------WYTLDYLCDFIYLLDTLVHMH 337
              |..::.|.|:|..:|....|.|.  |..:..||.        ...:|.:.|.::::|.|::..
Human   434 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 498

  Fly   338 EGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNR 400
            ..:::.. .:|....|:..|||  |||:| |:::.:|.||.......|....|       ::..|
Human   499 TTYVNANEEVVSHPGRIAVHYF--KGWFLIDMVAAIPFDLLIFGSGSEELIGL-------LKTAR 554

  Fly   401 LLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDS---WVYNL 462
            |||:.|:....||............:|...|    :.||.||:::||........||   |::||
Human   555 LLRLVRVARKLDRYSEYGAAVLFLLMCTFAL----IAHWLACIWYAIGNMEQPHMDSRIGWLHNL 615

  Fly   463 ----------NGTRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFAT 516
                      :|....:::.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:
Human   616 GDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYAS 680

  Fly   517 IVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAA 581
            |.||:.::|..:......:..:|..|::::.|.::.:.|..|:..:|.:.||.:..:|...||..
Human   681 IFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 745

  Fly   582 LPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKR 646
            .|:.|:|:|.:.::...|:..:.|.....|.|.||.:|.|.....|||.:...||:...:|.:.|
Human   746 FPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISR 810

  Fly   647 GKLSVVGDDGITVLATLGAGSVFGE-VSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETL 710
            |.:.::..|  .|:|.||...:||| :::....|...|     :||:|.|.||..:.:.||.|.|
Human   811 GSIEILRGD--VVVAILGKNDIFGEPLNLYARPGKSNG-----DVRALTYCDLHKIHRDDLLEVL 868

  Fly   711 SDYPEARSTLTQRGCQLLRKDGLLDEQIFAD----------SQRVHDSIEGGIEKLELSVENLNM 765
            ..|||                       |:|          :.|..:.|.|.....||.......
Human   869 DMYPE-----------------------FSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQ 910

  Fly   766 RLARLLAEYTASQAKIKQRLAK-LEMNG-----GPGTWRLECEPQSRARSGRLYSLQPKRRPRSR 824
            |..:|         ..::|..| .|..|     |||  |....|.||.|.|..:...|...| |.
Human   911 RKRKL---------SFRRRTDKDTEQPGEVSALGPG--RAGAGPSSRGRPGGPWGESPSSGP-SS 963

  Fly   825 PDAT 828
            |:::
Human   964 PESS 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	68/277 (25%)
		CAP_ED	604..717	CDD:237999	38/113 (34%)
		CLZ	720..790	CDD:465160	11/80 (14%)
KCNH2	XP_047276304.1	PAS_9	64..156	CDD:463873
		Ion_trans	435..694	CDD:459842	66/271 (24%)
		CAP_ED	768..879	CDD:237999	40/140 (29%)