Protein Alignment CngA and KCNH1

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_758872.1
• Gene: KCNH1 / 3756
• HGNCID: 6250
• Length: 989
• Species: Homo sapiens
• Alignment Length: 661
• Identity: 167/661 - (25%)
• Similarity: 267/661 - (40%)
• Gaps: 180/661 - (27%)

  Fly   214 TLQALRQR------------LTKRNRPKPPDWFLEKFSNTTN-TDKI------------------ 247
            |::.:||.            :.|:||  .|.||..|.:...| .||:
Human    79 TIEKVRQTFENYEMNSFEILMYKKNR--TPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIE 141

  Fly   248 -----GKGCPAMEDAALSS-------------------------EI--RGSSVLCNRLSVDPTLQ 280
                 |.|..|....||:|                         |:  .||.:|.......|...
Human   142 DDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTP 206

  Fly   281 SH-----------YRWLAIV-----SLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYL 329
            .|           :.|:.::     ::.|.||:.|...:      |..|   |..:|.:.|.|:|
Human   207 PHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQ------NNVA---WLVVDSIVDVIFL 262

  Fly   330 LDTLVHMHEGFL-DQGLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDL-----------AYIWWP 381
            :|.:::.|..|: ..|.::.|...:|.:|..|  |: :|:||.||.|:           |::..|
Human   263 VDIVLNFHTTFVGPAGEVISDPKLIRMNYLKT--WFVIDLLSCLPYDVINAFENVDEVSAFMGDP 325

  Fly   382 PETCSSLYLPCPV----------------IVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVV 430
            .:...:..:|.|:                :|||.||.|:.|..:.:.....|            |
Human   326 GKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAA------------V 378

  Fly   431 LAILVLI-----HWNACMYFAI-SYEIGFSSD-------SWVYNL-------------------N 463
            |.:||.:     ||.||::::| .||| |..|       ||:|.|                   .
Human   379 LVLLVCVFGLAAHWMACIWYSIGDYEI-FDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEG 442

  Fly   464 GTRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISN 527
            |...|::   ||.|.|::..:||::| ....|..|:|.:|.||..:.|.|::|||.||:.::...
Human   443 GPSKNSV---YISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQ 504

  Fly   528 MNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAI 592
            |......:...::.|:.::...:|...|..||:.:...|||.|..:|.|:||...|..::|:|.:
Human   505 MYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICV 569

  Fly   593 QVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGI 657
            .::....|:...|.....|.|.||.::.:....:|||.|...|:....:..|..|.|.|:.||
Human   570 HLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDD-- 632

  Fly   658 TVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQ 722
            .|:|.||.|.|||:|...|    .|..:..||||:|.|.||..: |||..:.:.::..|.|....
Human   633 EVVAILGKGDVFGDVFWKE----ATLAQSCANVRALTYCDLHVI-KRDALQKVLEFYTAFSHSFS 692

  Fly   723 RGCQL---LRK 730
            |...|   |||
Human   693 RNLILTYNLRK 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	80/324 (25%)
		CAP_ED	604..717	CDD:237999	38/112 (34%)
		CLZ	720..790	CDD:465160	5/14 (36%)
KCNH1	NP_758872.1	PAS_9	41..135	CDD:463873	13/57 (23%)
		Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000269|PubMed:27005320	151..162		4/10 (40%)
		PLN03192	220..>647	CDD:215625	121/455 (27%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472	463..468		1/4 (25%)
		PRK11753	608..>712	CDD:236969	37/103 (36%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:10880439	673..770		10/31 (32%)
		Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000250|UniProtKB:Q60603	699..701		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..886
		CAD (involved in subunit assembly). /evidence=ECO:0000250|UniProtKB:Q63472	924..964
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989