DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and CngB

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_611607.2	Gene:	CngB / 37479	FlyBaseID:	FBgn0266346	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	235/788 - (29%)
Similarity:	372/788 - (47%)	Gaps:	153/788 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 EQDEDEE-------EDDDDVDEDDDDEFGASVC-EDNPEEAIARADHDTQQKQHYQPNASDSSYV 192
            |::|:|:       |...|||||:.|   ..:| .::||    ..:.|..::....|:.::|..|
  Fly   279 EEEEEEKSSPLHQVESQPDVDEDEQD---VQICYNESPE----LQNEDRNERTQRTPSINESEIV 336

  Fly   193 ENGRKLIQEPS-------KRSKPSA-----------LRRTLQALRQRLTKR-------------- 225
                 .:.||.       ...|||:           ||..::.|.:|.|.|
  Fly   337 -----AVDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARANKVKSRIELPPTP 396

  Fly   226 ------NRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRG---------SSV-LCNRL- 273
                  :.|.||.   .|..:.:...|: :..||.:     |..||         |:| ||:.|
  Fly   397 SSSSTVSSPSPPP---TKSLHPSPQHKV-RLVPAGQ-----SPHRGRLFEADTPRSNVWLCSSLC 452

  Fly   274 -------SVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLD 331
                   ::||..:.:..||.:|||:.|||...:..||.|....|.....|...|:..|.|||||
  Fly   453 GANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLD 517

  Fly   332 TLVHMHE-GFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAY-------IWWPPETCSSL 388
            .:...|. .:|.:|..|::....|::|.....:.||:|::||.:|.|       :|
  Fly   518 VVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQAVW--------- 573

  Fly   389 YLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGF 453
                   :|..|..:|...||.|...:.....|:..|:.|.:..:|.:||..|.:|:|.|...|.
  Fly   574 -------LRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQGL 631

  Fly   454 SSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIV 518
            ..:.||::..|       ..|:..|.::|.|.|:||:.|.||...||:|:...:|.||.:||.::
  Fly   632 GQNRWVFSGKG-------HPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLI 689

  Fly   519 GNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALP 583
            |.|..:||.....:.|::...|...:||....:..|:::||..||.:||.|...|||..:|.|||
  Fly   690 GQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALP 754

  Fly   584 DKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGK 648
            ..||.:|||.||:.||.:|::|.|.|..||..|||||:...|.|||::||||:||:||||||.|:
  Fly   755 INLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQ 819

  Fly   649 LSVV-GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSD 712
            :.|: |.....|||||..||||||:|:|.|.|   .:||||:|||.|||:||.|:|.||.|.::.
  Fly   820 VQVMGGPSSDVVLATLTEGSVFGEISLLGING---ADRRTADVRSKGYSNLFVLSKSDLNEVIAY 881

  Fly   713 YPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGI------------EKLELSVENLNM 765
            ||.|::.|.:|..||:||:...:.:  .:.:|...:::..:            :.|:..::.|..
  Fly   882 YPTAQAILKKRARQLMRKNAARERE--EERERARSALQADVVIGNPKTPETAPKLLQTVIQALPF 944

  Fly   766 RLARLLAEYTASQAKIKQRLA---------KLEMNGGPGTWRLECEPQSRARSGR-----LYSLQ 816
            ....::.....|:...::|.:         |:|:.|.     .|.:.|...::||     |.|:|
  Fly   945 ESPAVVLITRGSKRMRRKRQSVQMETIVEPKMEVTGA-----AETQDQKGLKTGRCSPDLLSSIQ 1004

  Fly   817 PKRRPRSR 824
            .:.:.:.:
  Fly  1005 QELKSKHK 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	65/227 (29%)
		Ion_trans_2	<477..527	CDD:285168	20/49 (41%)
		Crp	598..>722	CDD:223736	68/124 (55%)
		CAP_ED	604..717	CDD:237999	63/113 (56%)
		CLZ	720..791	CDD:293134	13/91 (14%)
CngB	NP_611607.2	Ion_trans	488..704	CDD:278921	68/238 (29%)
		DUF4105	<672..755	CDD:290123	28/82 (34%)
		Crp	769..>898	CDD:223736	71/131 (54%)
		CAP_ED	775..889	CDD:237999	64/116 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445369
Domainoid	1	1.000	53	1.000	Domainoid score	I4197
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950