DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and Hcn4

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001074661.1	Gene:	Hcn4 / 330953	MGIID:	1298209	Length:	1201	Species:	Mus musculus

Alignment Length:	638	Identity:	158/638 - (24%)
Similarity:	281/638 - (44%)	Gaps:	103/638 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 GGGAE----QDEDEE------EDDDDVDEDDDDEFGASVCEDNPEEAIARADHDTQQKQHY---- 182
            |||:.    .|..||      |.|....||.... |.:...:.|..|...|.....|:...
Mouse   114 GGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPP-GLATEPERPATAAQPAASPPPQQPPQPASA 177

  Fly   183 ---QPNASDSSYVENGR----KLIQEPSKRSKPSA-LRRTLQALRQRLTKRNRPKPPDWFLEKFS 239
               ||:|..:..||.|.    :::.|...|...|. ::|...|:.|       |....:.|..|.
Mouse   178 SCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQFGAMLQ-------PGVNKFSLRMFG 235

  Fly   240 NTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRA 304
            :....::        |...:.|  .|..:      :.|.....:.|...:.|.::.|:|.:....
Mouse   236 SQKAVER--------EQERVKS--AGFWI------IHPYSDFRFYWDLTMLLLMVGNLIIIPVGI 284

  Fly   305 VFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFL--DQGLLVRDAFRLRRHYFHTKGWY-LD 366
            .|::...:.|  |...:.:.|..:|:|.:::...|.:  |...::.|..|::..|.  |.|: :|
Mouse   285 TFFKDENTTP--WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYL--KSWFVVD 345

  Fly   367 VLSMLPTDLAYIWWPPETCSSLYLPCPV--------IVRLNRLLRINRL------WE-----WFD 412
            .:|.:|.|..::.......|.:|.....        |:.|.||||::||      ||     .:|
Mouse   346 FISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 410

  Fly   413 RTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYS 477
            ......      ||..::..:|:|.||:.|:.|.:.....|..|.|| ::||..||:..:||.|:
Mouse   411 LASAVV------RIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWV-SINGMVNNSWGKQYSYA 468

  Fly   478 FYWSTLTLTTIG---ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRM 539
            .:.:...:..||   :.|...:||  ...:...:.|...:|..:|:..::|.:::.:|.::|.:.
Mouse   469 LFKAMSHMLCIGYGRQAPVGMSDV--WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 531

  Fly   540 DGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVR- 603
            ..|:|||:|.::..:...|:..::.:.: |....|||.:|..|.:.|:.||   ::.:..|.|.
Mouse   532 KQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESILGELSEPLREEI---INFNCRKLVAS 592

  Fly   604 --IFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV--GDDGITVLATLG 664
              :|.:.:|..:.:::.||:.:||.|||||.|:|.:||:||.::.|.:||:  |:..    ..|.
Mouse   593 MPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE----TKLA 653

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEAR 717
            .||.|||:.:|      |..||||:||:..|..|:.|:..:..|.|.:||..|
Mouse   654 DGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMR 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	57/244 (23%)
		Ion_trans_2	<477..527	CDD:285168	9/52 (17%)
		Crp	598..>722	CDD:223736	45/125 (36%)
		CAP_ED	604..717	CDD:237999	42/114 (37%)
		CLZ	720..791	CDD:293134
Hcn4	NP_001074661.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..121		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..183		10/48 (21%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		11/73 (15%)
		Ion_trans_N	218..260	CDD:285597	9/64 (14%)
		Ion_trans	280..525	CDD:278921	58/257 (23%)
		Crp	589..>724	CDD:223736	44/122 (36%)
		CAP_ED	595..703	CDD:237999	43/116 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..902
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..1201
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840