Protein Alignment CngA and CngB

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_061509935.1
• Gene: CngB / 3291342
• VectorBaseID: AGAMI1_010526
• Length: 1041
• Species: Anopheles gambiae
• Alignment Length: 813
• Identity: 248/813 - (30%)
• Similarity: 378/813 - (46%)
• Gaps: 138/813 - (16%)

  Fly    13 RVNTMMSNRRRPETESPKYGYNLSNRPMY------------------RTT-----RLVGPASSAP 54
            :||  ::.:||.::.|||.|.......:|                  |:|     |::...|:..
Mosquito   168 KVN--ITQKRRIKSFSPKGGGGGYKSKLYFRNGKIGCQEAENAVSNLRSTHELVKRIINDESNML 230

  Fly    55 AQLQLPCGSHQATLGVAPPPLEEISGGLFAPFAPTATITVEQAATSI--------------PMAV 105
            .:|:     ||.........||..|.....|.........|.|.||:              |:|:
Mosquito   231 VKLE-----HQHYTTAEQDGLESRSSSADTPVESLQMCVTESAGTSLCEDEVPAAGLAPSQPLAL 290

  Fly   106 DGEVHHLHYPRRSWQRKYRQGIHRQPGG---GAEQDEDEEEDDDDVDEDDDDEFGASVCEDN--- 164
            ..|.                 :...|||   |...:|.:...||....:..:.......||.
Mosquito   291 QQET-----------------VSMVPGGDSSGLNGEERQRHVDDGEHIESANGISMEPMEDRRNS 338

  Fly   165 --PEEAIARADHD--TQQKQHYQPNASDSSYVENGRKLIQEPSKRS------------KPSALRR 213
              |.|.:..:.:|  |.:.:|.....|:.:. :..|||...|:..|            |.|..:|
Mosquito   339 DCPSETMPTSGNDFVTVRLRHLANRFSERTR-KMRRKLEIPPTPSSSASAPSTAPSMQKHSVNQR 402

  Fly   214 TLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPT 278
            |:|  ...||.::..:.|......|            ||.......|..:           :||.
Mosquito   403 TIQ--NSALTLQSATETPGCSHYLF------------CPIFCCGGRSDNV-----------LDPQ 442

  Fly   279 LQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHE-GFLD 342
            .:.:..||.||||:.|||...:..|:.|.........:|..:|...|.|||||.|...|. .:|.
Mosquito   443 GKFYIAWLFIVSLSFLYNAWVIPLRSSFPYQTPENTKYWIAMDICADVIYLLDILFVKHRLMYLY 507

  Fly   343 QGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRL 407
            :|..|:|....|::|.....:.:|:|:::|.||.|:.:..|         .|:.|..|||:|...
Mosquito   508 EGFWVKDKNLTRKNYMRKLQFKMDLLALVPLDLLYLRFGTE---------HVVFRAPRLLKIQSF 563

  Fly   408 WEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQR 472
            ||:|...:.....|:..|:.|.:..:|.:||..||.|:|.|...|..|:.||:|..|       .
Mosquito   564 WEFFKLIDRVISSPHIIRVVKTLTYMLYMIHLTACAYYAYSAYQGLGSNRWVFNNKG-------H 621

  Fly   473 QYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQN 537
            .|:..|.::|.|.|:||:.|.||.:.|.:|:.|.:|.||.:||.::|.|..:|:....::.|::.
Mosquito   622 AYVRCFAFATKTATSIGKNPKPEKEGELMFMTAAWLMGVFVFALLIGQIRDIIATATRSKSEYKQ 686

  Fly   538 RMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQV 602
            .:|...:||....:..:|:.||..||.:||.|...|||..::.|||..||.:|||.||:.||.:|
Mosquito   687 LVDETLEYMRRLNLPTDLQRRVKMWFTFTWEQQKCLDETHIMDALPANLKTDIAISVHIQTLSKV 751

  Fly   603 RIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVG---DDGITVLATLG 664
            ::|.|.|..||..|||||:...|.|||::||||:|||||||||.|::.|:|   :|  .|||||.
Mosquito   752 QLFADCEEALLRELVLKLRSVTFLPGDFVCRKGEVGKEMYIVKTGQVQVMGGPRND--VVLATLY 814

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR 729
            .||||||:|:|.|.| ..||||||:|||.|:|:||.|:|.||.|.:..||.|::.|.:|...|:|
Mosquito   815 EGSVFGEISLLAING-AEGNRRTADVRSKGFSNLFVLSKSDLNEAIVYYPNAQAILKKRAKSLMR 878

  Fly   730 KDGLLDEQIFADSQRVHDSIEGGIEKLELSVEN 762
            |:...::   |:||:   ||:....::::.:.|
Mosquito   879 KNAAREK---AESQQ---SIDTKGSEVDVVIRN 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	81/247 (33%)
		CAP_ED	604..717	CDD:237999	66/115 (57%)
		CLZ	720..790	CDD:465160	11/43 (26%)
CngB	XP_061509935.1	None