DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and eag

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	181/798 - (22%)
Similarity:	319/798 - (39%)	Gaps:	170/798 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 VC-----EDNPEEAIARADH--DTQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQA 217
            ||     |...:|.:.|.::  :.||:..::......:.::.|..|.|....:::.:.|...||.
  Fly    69 VCGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLLLQV 133

  Fly   218 LRQR----------LTKRN---RPKPPD-------WFLEKFS----NTTNTDKIGKGCPAMEDAA 258
            ...|          ||.|:   ..:|.|       ..|.||:    :.|.:.:.....|.::|..
  Fly   134 APIRNERDLVVLFLLTFRDITALKQPIDSEDTKGVLGLSKFAKLARSVTRSRQFSAHLPTLKDPT 198

  Fly   259 LSSEIRGSSVLCNRLSVDPTLQSHYR----------------------WLAI-----VSLAVLYN 296
            ..|.      |.:.:|:...:...||                      |:.:     .::.|.||
  Fly   199 KQSN------LAHMMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPYN 257

  Fly   297 IIFVVGRAVFWEINK-SAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFH 359
            :.|.         || |.......:|.:.|.|:.:|.:::.|..|:.. |.:|.|...:|.:|.
  Fly   258 VAFK---------NKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYL- 312

  Fly   360 TKGWY-LDVLSMLPTDLAYIWWPPET-CSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPN 422
             |.|: :|:||.||.|:...:...|. ..||:....|:    ||||:.|:....||   ...|..
  Fly   313 -KSWFIIDLLSCLPYDVFNAFDRDEDGIGSLFSALKVV----RLLRLGRVVRKLDR---YLEYGA 369

  Fly   423 AFRICKVVLAILVLIHWNACMYFAIS-----------------------YEIGFSSDSWVYNLNG 464
            |..|..:...:|| .||.||::::|.                       |...:|:|:....:||
  Fly   370 AMLILLLCFYMLV-AHWLACIWYSIGRSDADNGIQYSWLWKLANVTQSPYSYIWSNDTGPELVNG 433

  Fly   465 TRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNM 528
            ....::   |:.:.|::...:|::| .....|.|.|.:|.:...:...|::|||.|::.::|..|
  Fly   434 PSRKSM---YVTALYFTMTCMTSVGFGNVAAETDNEKVFTICMMIIAALLYATIFGHVTTIIQQM 495

  Fly   529 NVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQ 593
            ..|..::.:.::.|:::|....|...|..||:.:...||:.:..||.|:||...|..:||:|.:.
  Fly   496 TSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDTEKVLNYCPKDMKADICVH 560

  Fly   594 VHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGIT 658
            ::.....:...|.....|.|.||.:...:...:|||.:...|:....:..:..|.|.|:.||  .
  Fly   561 LNRKVFNEHPAFRLASDGCLRALAMHFMMSHSAPGDLLYHTGESIDSLCFIVTGSLEVIQDD--E 623

  Fly   659 VLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQR 723
            |:|.||.|.|||:    :...:....:..||||:|.|.||..:.:..|.|.|..|....::..:
  Fly   624 VVAILGKGDVFGD----QFWKDSAVGQSAANVRALTYCDLHAIKRDKLLEVLDFYSAFANSFAR- 683

  Fly   724 GCQLLRKDGLLDEQIF---ADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTAS---QAKIK 782
              .|:....|....||   ||.:|..:..|....:.:|. :|.:..:.::.:::..:   ||..|
  Fly   684 --NLVLTYNLRHRLIFRKVADVKREKELAERRKNEPQLP-QNQDHLVRKIFSKFRRTPQVQAGSK 745

  Fly   783 QRLAKLEMNGGPGTWRLECEPQSRARSG-------------------RLYSL------QPKRRPR 822
                  |:.||.|        ||....|                   |:.|.      .|...|.
  Fly   746 ------ELVGGSG--------QSDVEKGDGEVERTKLPAKLTLTEDARILSTAAAPSPSPSPSPS 796

  Fly   823 SRPDATAKSSDAAKQNTL 840
            |.| .:|:|:.|:|...|
  Fly   797 SGP-PSARSTRASKWGRL 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	62/247 (25%)
		Ion_trans_2	<477..527	CDD:285168	13/50 (26%)
		Crp	598..>722	CDD:223736	34/123 (28%)
		CAP_ED	604..717	CDD:237999	34/112 (30%)
		CLZ	720..791	CDD:293134	14/76 (18%)
eag	NP_001036275.1	PAS_9	28..155	CDD:290162	17/85 (20%)
		PAS	40..153	CDD:238075	17/83 (20%)
		Ion_trans	254..499	CDD:278921	67/266 (25%)
		Ion_trans_2	<440..494	CDD:285168	14/53 (26%)
		Crp	565..>702	CDD:223736	38/145 (26%)
		CAP_ED	571..682	CDD:237999	34/116 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm987
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840