DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and Cngb3

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_038955.1	Gene:	Cngb3 / 30952	MGIID:	1353562	Length:	694	Species:	Mus musculus

Alignment Length:	691	Identity:	192/691 - (27%)
Similarity:	314/691 - (45%)	Gaps:	140/691 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 EEAIARADHDTQ------------QKQHYQPNASDSSYVENG-RKLIQEPSKRSKPSALRRTLQA 217
            :..||:.|:.::            :|.|   :..|:|..||. |.....|....: :.|.||:..
Mouse    32 QPTIAQGDNQSEKEPLRSRTPITFEKSH---SKEDNSTGENSLRDFTPNPDPECR-AELTRTMAE 92

  Fly   218 LRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSS--------------------- 261
            :.:..|.:.||..   |..|...|:..::       ..||.|.:
Mouse    93 MEKTRTGKERPVS---FKTKVLETSIINE-------YTDAHLHNLVERMRERTALYKKTLTEEEN 147

  Fly   262 --EIRGSSVLCNRLSVDP----------------------TLQSHYR------------------ 284
              |:..||......::.|                      .::.|.|
Mouse   148 FPEVEASSQTAMSTNISPKQENNSKLKEHQDTFSFKPQRVPVKEHLRRMILPRSIDSYTDRVYLL 212

  Fly   285 WLAIVSLAVLYNIIFVVGRAVF---WEINKSAPAFWYTLDYLCDFIYLLD-TLVHMHEGFLDQGL 345
            ||.:|::|..:|...:..|.||   ...||:   :|...|.:||.|||.| .|:.....|:..|.
Mouse   213 WLLLVTIAYNWNCWLLPVRLVFPCQTPDNKN---YWIITDIVCDIIYLCDILLIQPRLQFVRGGE 274

  Fly   346 LVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEW 410
            ::.|:..|:|:|..:..:.:||.|:||.::.||::....          |.|.||:|:....:|:
Mouse   275 IIVDSNELKRNYRSSTKFRMDVASLLPFEVLYIFFGVNP----------IFRANRILKYTSFFEF 329

  Fly   411 FDRTETATGYPNAFRICKVVLAILVLIHWNACMYF-AISYEIGFSSDSWVYNLNGTRNNTLQRQY 474
            ....|:.......:|:.:....:|.|:|.|||:|: |..|| |..|..||||..|.:       |
Mouse   330 NHHLESIMDKAYVYRVIRTTGYLLFLLHINACVYYWASDYE-GIGSTKWVYNGEGNK-------Y 386

  Fly   475 IYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGN----IGSMISNMNVARVEF 535
            :..|||:..||.|||..|.|:...|.:|...:|.:||.:|::::|.    ||:..:|.|.    |
Mouse   387 LRCFYWAVRTLITIGGLPEPQTSFEIVFQFLNFFSGVFVFSSLIGQMRDVIGAATANQNY----F 447

  Fly   536 QNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLK 600
            |..||.:..||....:...::.||..|..|||:....|||..:|..||..::..||:.::...:.
Mouse   448 QACMDHIIAYMNKYSIPQSVQYRVRTWLEYTWNSQRILDESNLLENLPTAMQLSIALDINFSIID 512

  Fly   601 QVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV-GDDGITVLATLG 664
            :|.:|...:..::..|:|:||..::.|||::|:||::||||||:|.|::.|: |.||..||.||.
Mouse   513 KVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGAQVLVTLK 577

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR 729
            |||||||:|:|...|   ||||||:|.:.|:::|..|.|:.|.|.|..||.::..|.::...||.
Mouse   578 AGSVFGEISLLAKGG---GNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKKLLMKKAKILLS 639

  Fly   730 KDGLLDEQIFA------------DSQRVHDSIEGGIEKLEL 758
            :.|...:.|.|            ::.|:...:.|...|::|
Mouse   640 QKGKTTQAIPARPGPAFLFPPKEETPRMLKVLLGNTGKVDL 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	70/225 (31%)
		Ion_trans_2	<477..527	CDD:285168	19/53 (36%)
		Crp	598..>722	CDD:223736	55/124 (44%)
		CAP_ED	604..717	CDD:237999	53/113 (47%)
		CLZ	720..791	CDD:293134	10/51 (20%)
Cngb3	NP_038955.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..82		11/52 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..177		4/30 (13%)
		Ion_trans	228..445	CDD:278921	73/237 (31%)
		Crp	510..>640	CDD:223736	57/132 (43%)
		CAP_ED	516..624	CDD:237999	51/110 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850