Protein Alignment CngA and Cnga2

DIOPT Version :9

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_037060.2
• Gene: Cnga2 / 25411
• RGDID: 2367
• Length: 664
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 314/639 - (49%)
• Similarity: 407/639 - (63%)
• Gaps: 35/639 - (5%)

  Fly   165 PEEAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQ---ALRQRLTK-- 224
            |....|....|.:.....|..|:|.......::|.:..:.|......:|.::   .:|....|
  Rat    22 PPSIKANGKDDHRAGSRPQSVAADDDTSSELQRLAEMDTPRRGRGGFQRIVRLVGVIRDWANKNF 86

  Fly   225 RNRPKPPDWFLEKFSN------TTN--TDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQS 281
            |.....||.|||:|..      ||:  .||.||          ..|.:|:........:||....
  Rat    87 REEEPRPDSFLERFRGPELQTVTTHQGDDKGGK----------DGEGKGTKKKFELFVLDPAGDW 141

  Fly   282 HYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQGLL 346
            :||||.::::.||||...:|.||.|.::.::....|..|||..|.:|:.|.::.:..|||:||||
  Rat   142 YYRWLFVIAMPVLYNWCLLVARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLL 206

  Fly   347 VRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWF 411
            |:|..:||.:|.||..:.|||.|::||||.|.      ...::.|   .||.||||...|::|:|
  Rat   207 VKDPKKLRDNYIHTLQFKLDVASIIPTDLIYF------AVGIHSP---EVRFNRLLHFARMFEFF 262

  Fly   412 DRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVY-NLNGTRNNTLQRQYI 475
            |||||.|.|||.|||..:||.|||:||||||:|:.||..|||..|:||| |:.......|.|:||
  Rat   263 DRTETRTSYPNIFRISNLVLYILVIIHWNACIYYVISKSIGFGVDTWVYPNITDPEYGYLAREYI 327

  Fly   476 YSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMD 540
            |..||||||||||||||.|..|.|||||:.|||.|||||||||||:||||||||..|.|||.::|
  Rat   328 YCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKID 392

  Fly   541 GVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIF 605
            .||.||.||:|..::||:||:||.|.|:....:||..||..||.||:|||||.||:.|||:||||
  Rat   393 AVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIF 457

  Fly   606 HDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFG 670
            .|.|.|||..|||||:.||||||||||||||:||||||:|.|||:||.|||:|..|.|.|||.||
  Rat   458 QDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFG 522

  Fly   671 EVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLD 735
            |:|:|.|.|::.|||||||:|||||||||||:|.||.|.:::||:|:..|.:||.::|.|:||||
  Rat   523 EISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLD 587

  Fly   736 EQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLE 789
            |...|.|..|  .::..:|:||.:::.|..|.||||||||.:|.|:|||:..||
  Rat   588 ENEVAASMEV--DVQEKLEQLETNMDTLYTRFARLLAEYTGAQQKLKQRITVLE 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	120/220 (55%)
		Ion_trans_2	<477..527	CDD:285168	39/49 (80%)
		Crp	598..>722	CDD:223736	85/123 (69%)
		CAP_ED	604..717	CDD:237999	78/112 (70%)
		CLZ	720..791	CDD:293134	33/70 (47%)
Cnga2	NP_037060.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		6/28 (21%)
		Ion_trans	142..384	CDD:395416	134/250 (54%)
		Radical_SAM	417..>470	CDD:418514	30/52 (58%)
		CAP_ED	456..572	CDD:237999	79/115 (69%)
		CLZ	572..639	CDD:406832	31/68 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1752
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	587	1.000	Inparanoid score	I962
OMA	1	1.010	-	-		QHG48384
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	1	1.000	-	-		otm45723
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	LDO	PTHR45638
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X511
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980