DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and Kcnh8

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_659563.1	Gene:	Kcnh8 / 246325	RGDID:	2549	Length:	1102	Species:	Rattus norvegicus

Alignment Length:	692	Identity:	170/692 - (24%)
Similarity:	297/692 - (42%)	Gaps:	151/692 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 ASDSSYVENGRKLIQEPSKRSK-----------PSALRRT---LQALRQRLTKRNRPKPPDWFLE 236
            ||.....:...|:..|..|..:           .||.||:   |..:...|.:|.:.|      .
  Rat   128 ASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNK------L 186

  Fly   237 KFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAI-----VSLAVLYN 296
            |.:|....||     ||..:..:|...:...:|.:    ..|.::.:.||.:     |::.|.||
  Rat   187 KINNNVFVDK-----PAFPEYKVSDAKKSKFILLH----FSTFKAGWDWLILLATFYVAVTVPYN 242

  Fly   297 IIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHT 360
            :.|:...      :.|........|...:.::::|.:::....::.: |.::.:|..:..||..|
  Rat   243 VCFIGNE------DLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTT 301

  Fly   361 KGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDR-TETATGYPNA 423
              |: :|:::.||.||.|.:  ..|..||.    .:::..||||:.||.:..|| ::.:|
  Rat   302 --WFIIDLIAALPFDLLYAF--NVTVVSLV----HLLKTVRLLRLLRLLQKLDRYSQHST----- 353

  Fly   424 FRICKVVLAIL-----VLIHWNACMYFAI-----------SYEIGFSSDSWVYNLNGTR------ 466
                 :||.:|     :|.||.||:::.|           .:|:|     |::.| |.|
  Rat   354 -----IVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVG-----WLHEL-GKRLESPYY 407

  Fly   467 -NNTL-----QRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSM 524
             ||||     :..||.:.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.::
  Rat   408 GNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAI 472

  Fly   525 ISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAE 589
            |..|......:..|...:|.::....:..:|:.|::.:|..|||.:..:|...:|...||:|:::
  Rat   473 IQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD 537

  Fly   590 IAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGD 654
            |.:.::.:.| |:.:|.....|.|.:|.|.:|....:||:|:.|:||..:.:|.|..|.:.|:.|
  Rat   538 ITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKD 601

  Fly   655 DGITVLATLGAGSVFG-EVSVLE--IAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEA 716
            .  .|||.||.|.:.| .:|:.:  |..|       |:|::|.|.||.|:..:.|:|.|..|||.
  Rat   602 S--MVLAILGKGDLIGANLSIKDQVIKTN-------ADVKALTYCDLQCIILKGLFEVLGLYPEY 657

  Fly   717 RSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAK- 780
            .....:                  |.|  ||......|..|..|      ::||..:.|..||:
  Rat   658 AHKFVE------------------DIQ--HDLTYNLREGHESDV------ISRLSNKSTVPQAEP 696

  Fly   781 -----IKQRLAKLEMNGGPGTWRLECEPQSRARSGRLYSLQP 817
                 ||:||..:          :|.|.:.........||.|
  Rat   697 KGNGSIKKRLPSI----------VEDEEEEEVEEEETTSLSP 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	63/251 (25%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	42/126 (33%)
		CAP_ED	604..717	CDD:237999	40/115 (35%)
		CLZ	720..791	CDD:293134	16/76 (21%)
Kcnh8	NP_659563.1	PAS_9	29..135	CDD:290162	2/6 (33%)
		PAS	42..133	CDD:238075	2/4 (50%)
		Ion_trans	239..481	CDD:278921	68/271 (25%)
		Ion_trans_2	<421..475	CDD:285168	17/53 (32%)
		Selectivity filter. /evidence=ECO:0000250	434..439		1/4 (25%)
		Crp	548..707	CDD:223736	56/193 (29%)
		CAP_ED	551..662	CDD:237999	40/119 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	683..744		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..793
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840