DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CngA and KCNH3

DIOPT Version :9

Sequence 1:NP_001188960.1 Gene:CngA / 36806 FlyBaseID:FBgn0261612 Length:840 Species:Drosophila melanogaster
Sequence 2:XP_011536387.1 Gene:KCNH3 / 23416 HGNCID:6252 Length:1094 Species:Homo sapiens


Alignment Length:719 Identity:179/719 - (24%)
Similarity:294/719 - (40%) Gaps:170/719 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 RSKP-SALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGC----PAMEDAALSSEIR 264
            |||. :|.||..:|:...|:...:.:|           ....|:.||.    |.:.:..::: ||
Human   159 RSKGFNANRRRSRAVLYHLSGHLQKQP-----------KGKHKLNKGVFGEKPNLPEYKVAA-IR 211

  Fly   265 GSSVL---CNRLSVDPTLQSHYRWLAIVSLAVLYNIIFV-----VGRAVFWEINKSAPAFWYTLD 321
            .|..:   |..|..        .|...:.||.||..:.|     |..|......:..|:   ..|
Human   212 KSPFILLHCGALRA--------TWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPS---VCD 265

  Fly   322 YLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIWWPPET 384
            ...:.:::||.:::....|:.: |.:|.....:..||..|  |: |||::.||.||.:.:     
Human   266 LAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTT--WFLLDVIAALPFDLLHAF----- 323

  Fly   385 CSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAIL-----VLIHWNACMY 444
            ..::|.... :::..||||:.||....||..         :...|||.:|     :|.||.||::
Human   324 KVNVYFGAH-LLKTVRLLRLLRLLPRLDRYS---------QYSAVVLTLLMAVFALLAHWVACVW 378

  Fly   445 FAISYEIGFSSDS------WV----------YNLNGTR-------------------NNT----- 469
            |.|......||:|      |:          |.|.|.|                   |.|     
Human   379 FYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELL 443

  Fly   470 ----LQRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMISNMN 529
                |:..||.|.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.::|..|.
Human   444 GGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMY 508

  Fly   530 VARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQV 594
            ..|..:.:|...::.|:...|:...|:.|::.:|..||:.:..:|...:|.:|||:|:|:||:.:
Human   509 ARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHL 573

  Fly   595 HMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITV 659
            |.:.| |:.:|.....|.|.||.|.|:....:||:|:..:||..:.:|.|..|.:.|:  .|.||
Human   574 HKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVL--KGGTV 635

  Fly   660 LATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRG 724
            ||.||.|.:.|    .|:.......:..|:|:.|.|..|.||....|.::|:.|||.....: ||
Human   636 LAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFS-RG 695

  Fly   725 CQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAE---------------- 773
            .:     |.|...:.|.         ||..:::.|..:.:..|...|.|                
Human   696 LR-----GELSYNLGAG---------GGSAEVDTSSLSGDNTLMSTLEEKETDGEQGPTVSPAPA 746

  Fly   774 -------------YTASQAKI--KQRLAKLEMNGGPGTWRLECEPQSRARSGRLYSLQPKRRPRS 823
                         .::|.||:  .:|.|.....||            |.|.||..:|:.:..|.:
Human   747 DEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGG------------RGRPGRAGALKAEAGPSA 799

  Fly   824 RPDA 827
            .|.|
Human   800 PPRA 803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngANP_001188960.1 Ion_trans 309..529 CDD:278921 67/271 (25%)
Ion_trans_2 <477..527 CDD:285168 16/50 (32%)
Crp 598..>722 CDD:223736 40/123 (33%)
CAP_ED 604..717 CDD:237999 38/112 (34%)
CLZ 720..791 CDD:293134 16/101 (16%)
KCNH3XP_011536387.1 PAS 42..133 CDD:238075
PAS_3 42..123 CDD:285623
Ion_trans 246..511 CDD:278921 70/284 (25%)
Ion_trans_2 <452..506 CDD:285168 18/53 (34%)
CAP_ED 582..692 CDD:237999 38/115 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145012
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.