Protein Alignment CngA and KCNH4

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_036417.1
• Gene: KCNH4 / 23415
• HGNCID: 6253
• Length: 1017
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 180/704 - (25%)
• Similarity: 303/704 - (43%)
• Gaps: 145/704 - (20%)

  Fly   183 QPNASDSSYVEN--GRKLIQEPSKRSKPSALRRTLQALRQRLT-----------KRN----RPKP 230
            |....||:: ||  ||:     ....|..:.||..:.:..|||           |.|    .|||
Human   144 QGGRGDSNH-ENSLGRR-----GATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKP 202

  Fly   231 --PDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAV 293
              |::            |:             :.:.||..|....||...:     |..::.||.
Human   203 SVPEY------------KV-------------ASVGGSRCLLLHYSVSKAI-----WDGLILLAT 237

  Fly   294 LYNIIFVVGRAVFWEINKSAPAFWYTL--DYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRR 355
            .|..:.|.....|...:.:.....:||  |...:.:::||.:::....::.| |.::.....:..
Human   238 FYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGL 302

  Fly   356 HYFHTKGW-YLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATG 419
            ||..|  | ::|:::.||.||.||:  ..|.:||.    .:::..||||:.||.:..:|....:.
Human   303 HYLAT--WFFIDLIAALPFDLLYIF--NITVTSLV----HLLKTVRLLRLLRLLQKLERYSQCSA 359

  Fly   420 YPNAFRICKVVLAIL-----VLIHWNACMYFAIS-----------YEIGFSSDSWVYNL------ 462
                     |||.:|     :|.||.||:::.|.           ::||     |::.|
Human   360 ---------VVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIG-----WLHELGKRLEV 410

  Fly   463 ---NGTRNNTLQRQ-YIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIG 522
               ||:.....:|. ||.:.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.
Human   411 PYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVT 475

  Fly   523 SMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLK 587
            ::|..|...|..:.:||..:|.::...|:...|:.|::.:|..||:.:..:|...:|...||:|:
Human   476 AIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR 540

  Fly   588 AEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV 652
            |:||:.::.:.| |:.:|.....|.|.||.|.:|....:||:|:.|:||..:..|.|..|.|.|:
Human   541 ADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVL 604

  Fly   653 GDDGITVLATLGAGSVFGEVSVLEIAGNRTG--------NRRTANVRSLGYSDLFCLAKRDLWET 709
            .|:  .|||.||.|.:.|  :.:...|...|        .:.:|:|::|.|..|..|:.|.|.|.
Human   605 RDN--MVLAILGKGDLIG--ADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEV 665

  Fly   710 LSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEY 774
            |..|||..:..         :.||..:..|        ::..|.:...||..:.:.||::..:|.
Human   666 LRLYPEYGAAF---------RAGLPRDLTF--------NLRQGSDTSGLSRFSRSPRLSQPRSES 713

  Fly   775 TASQA-----KIKQRLAKLEMNGGPGTWRLECEPQ-SRAR-SGRLYSLQPKRRP 821
            ..|.:     .|.:..:..|..|||...|....|. |.|| .|.|.||..:..|
Human   714 LGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELP 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	68/277 (25%)
		CAP_ED	604..717	CDD:237999	41/120 (34%)
		CLZ	720..790	CDD:465160	11/74 (15%)
KCNH4	NP_036417.1	PRK13559	41..>179	CDD:237427	10/40 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..157		5/13 (38%)
		PLN03192	177..>620	CDD:215625	129/497 (26%)
		Selectivity filter. /evidence=ECO:0000250	439..444		1/4 (25%)
		cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060	556..620		25/65 (38%)
		cNMP_binding	578..667	CDD:459637	30/92 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..749		14/57 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..803
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..875
		PHA02682	838..>999	CDD:177464
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..1017