DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngA and KCNH4

DIOPT Version :9

Sequence 1:NP_001188960.1 Gene:CngA / 36806 FlyBaseID:FBgn0261612 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_036417.1 Gene:KCNH4 / 23415 HGNCID:6253 Length:1017 Species:Homo sapiens


Alignment Length:704 Identity:180/704 - (25%)
Similarity:303/704 - (43%) Gaps:145/704 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 QPNASDSSYVEN--GRKLIQEPSKRSKPSALRRTLQALRQRLT-----------KRN----RPKP 230
            |....||:: ||  ||:     ....|..:.||..:.:..|||           |.|    .|||
Human   144 QGGRGDSNH-ENSLGRR-----GATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKP 202

  Fly   231 --PDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAV 293
              |::            |:             :.:.||..|....||...:     |..::.||.
Human   203 SVPEY------------KV-------------ASVGGSRCLLLHYSVSKAI-----WDGLILLAT 237

  Fly   294 LYNIIFVVGRAVFWEINKSAPAFWYTL--DYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRR 355
            .|..:.|.....|...:.:.....:||  |...:.:::||.:::....::.| |.::.....:..
Human   238 FYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGL 302

  Fly   356 HYFHTKGW-YLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATG 419
            ||..|  | ::|:::.||.||.||:  ..|.:||.    .:::..||||:.||.:..:|....:.
Human   303 HYLAT--WFFIDLIAALPFDLLYIF--NITVTSLV----HLLKTVRLLRLLRLLQKLERYSQCSA 359

  Fly   420 YPNAFRICKVVLAIL-----VLIHWNACMYFAIS-----------YEIGFSSDSWVYNL------ 462
                     |||.:|     :|.||.||:::.|.           ::||     |::.|      
Human   360 ---------VVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIG-----WLHELGKRLEV 410

  Fly   463 ---NGTRNNTLQRQ-YIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIG 522
               ||:.....:|. ||.:.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.
Human   411 PYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVT 475

  Fly   523 SMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLK 587
            ::|..|...|..:.:||..:|.::...|:...|:.|::.:|..||:.:..:|...:|...||:|:
Human   476 AIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR 540

  Fly   588 AEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV 652
            |:||:.::.:.| |:.:|.....|.|.||.|.:|....:||:|:.|:||..:..|.|..|.|.|:
Human   541 ADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVL 604

  Fly   653 GDDGITVLATLGAGSVFGEVSVLEIAGNRTG--------NRRTANVRSLGYSDLFCLAKRDLWET 709
            .|:  .|||.||.|.:.|  :.:...|...|        .:.:|:|::|.|..|..|:.|.|.|.
Human   605 RDN--MVLAILGKGDLIG--ADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEV 665

  Fly   710 LSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEY 774
            |..|||..:..         :.||..:..|        ::..|.:...||..:.:.||::..:|.
Human   666 LRLYPEYGAAF---------RAGLPRDLTF--------NLRQGSDTSGLSRFSRSPRLSQPRSES 713

  Fly   775 TASQA-----KIKQRLAKLEMNGGPGTWRLECEPQ-SRAR-SGRLYSLQPKRRP 821
            ..|.:     .|.:..:..|..|||...|....|. |.|| .|.|.||..:..|
Human   714 LGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELP 767

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngANP_001188960.1 Ion_trans 309..529 CDD:278921 62/250 (25%)
Ion_trans_2 <477..527 CDD:285168 15/50 (30%)
Crp 598..>722 CDD:223736 43/131 (33%)
CAP_ED 604..717 CDD:237999 41/120 (34%)
CLZ 720..791 CDD:293134 12/75 (16%)
KCNH4NP_036417.1 PAS_9 29..135 CDD:290162
PAS 29..133 CDD:238075
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..157 5/13 (38%)
Ion_trans 244..486 CDD:278921 65/263 (25%)
Ion_trans_2 <426..480 CDD:285168 17/53 (32%)
Selectivity filter. /evidence=ECO:0000250 439..444 1/4 (25%)
CAP_ED 556..676 CDD:237999 41/123 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..749 14/57 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 772..803
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..875
PHA02682 838..>999 CDD:177464
bZIP <872..901 CDD:304365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..1017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145013
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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