DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and Kcnh6

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001032801.1	Gene:	Kcnh6 / 192775	MGIID:	2684139	Length:	950	Species:	Mus musculus

Alignment Length:	674	Identity:	170/674 - (25%)
Similarity:	288/674 - (42%)	Gaps:	118/674 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 PDWFLEKFSNTTN--TDKIGKGCPAMEDAALSS-EIRGSSVLCNRLSVDPTLQSHYR-----WLA 287
            |...:|:..|.|.  |..:..|...:.:..|.: .|...::|            ||.     |..
Mouse   209 PHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTIL------------HYSPFKAVWDW 261

  Fly   288 IVSLAVLYNIIFVVGRAVFW---EINKSAPAFWYT------LDYLCDFIYLLDTLVHMHEGFLD- 342
            ::.|.|:|..:|....|.|.   :.:.......||      :|.:.|.::::|.:::....:::
Mouse   262 LILLLVIYTAVFTPYSAAFLLSDQDDSQRGTCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNT 326

  Fly   343 QGLLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINR 406
            ...:|....|:..|||  |||:| |:::.:|.||.......:..::|.    .:::..||||:.|
Mouse   327 NDEVVSHPRRIAVHYF--KGWFLIDMVAAIPFDLLIFRTGSDETTTLI----GLLKTARLLRLVR 385

  Fly   407 LWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISY--------EIGFSSDSWVYNL- 462
            :....||............:|...|    :.||.||:::||..        :||     |:.:|
Mouse   386 VARKLDRYSEYGAAVLFLLMCTFAL----IAHWLACIWYAIGNVERPYLEPKIG-----WLDSLG 441

  Fly   463 -------NGT---RNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFAT 516
                   ||:   ...::|.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:
Mouse   442 AQLGKHYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYAS 506

  Fly   517 IVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAA 581
            |.||:.::|..:......:..:|..||:::.|.::.:.|..|:..:|.:.||.:..:|...||..
Mouse   507 IFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 571

  Fly   582 LPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKR 646
            .|:.|:|:|.:.:|...|:....|.....|.|.||.:|.|.....|||.:...|||...:|.:.|
Mouse   572 FPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISR 636

  Fly   647 GKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLS 711
            |.:.::.||  .|:|.||...:|||.:.|..   |.| :.:|:||:|.|.||..:.:.||.|.|.
Mouse   637 GSIEILRDD--VVVAILGKNDIFGEPASLHA---RPG-KSSADVRALTYCDLHKIHRADLLEVLD 695

  Fly   712 DYPEARSTLTQR---GCQLLRKDGLL-----------DEQIFADSQRVHDSIEGGIEKLELSVEN 762
            .||....|...:   ...|...||.|           |.|.|.    ::||..|...  .||:.:
Mouse   696 MYPAFADTFWNKLEVTFNLRDADGGLHSTPRQAPGNQDPQGFF----LNDSQSGAAP--SLSISD 754

  Fly   763 LNMRLARLLAEYTASQAKIKQRL--------AKLE-----MNGGPGTWRLECEPQSRARSGRLYS 814
            .:.....||.:...|....:::|        .|||     ||      |||    ||..|.....
Mouse   755 TSGLWPELLQQMPPSPPNPREKLDCWPRELGFKLEQLQAQMN------RLE----SRVSSDLSRI 809

  Fly   815 LQPKRRPRSRPD---ATAKSSDAA 835
            ||..:.|:..|.   ....|||.|
Mouse   810 LQLLQHPQGHPGYILGAPASSDLA 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	57/247 (23%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	43/123 (35%)
		CAP_ED	604..717	CDD:237999	41/112 (37%)
		CLZ	720..791	CDD:293134	19/97 (20%)
Kcnh6	NP_001032801.1	PAS_9	29..132	CDD:290162
		PAS	41..132	CDD:238075
		Ion_trans	296..520	CDD:278921	56/238 (24%)
		Ion_trans_2	<463..517	CDD:285168	16/53 (30%)
		Crp	588..>701	CDD:223736	42/118 (36%)
		CAP_ED	594..705	CDD:237999	42/116 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840