Protein Alignment CngA and unc-103

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001368173.1
• Gene: unc-103 / 175527
• WormBaseID: WBGene00006830
• Length: 898
• Species: Caenorhabditis elegans
• Alignment Length: 696
• Identity: 170/696 - (24%)
• Similarity: 307/696 - (44%)
• Gaps: 157/696 - (22%)

  Fly   139 EDEEEDD---DDVDEDDDDE-------FGAS--VCEDNPEEAIARADHDTQQKQHYQPNASDSSY 191
            ||||:|:   :..|::||.:       .|:|  |.||    .:..:|.:.:.|:.:..::|.:|.
 Worm    15 EDEEDDEVFFEPADKNDDKQRFLPKQSRGSSRFVSED----VLNNSDDEEENKRCHLVSSSHASL 75

  Fly   192 VENGRKLIQEPSKRSKPSALRRTLQALRQRL---------------------TKRNRPKPPDWFL 235
                |.|...||.:|..|            :                     |:||
 Worm    76 ----RSLSPCPSLQSSSS------------IGGCGGGGMVGGGGGGGAGGSSTRRN--------- 115

  Fly   236 EKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPT-----------------LQS-- 281
            ...::|::|.....|..|      |:.:|..|:....||.||.                 ||.
 Worm   116 AAIASTSSTTSSAAGRRA------SAFVRRMSMAIPTLSADPVPFSAVLSLGADVLPEYKLQPTR 174

  Fly   282 -------HYR-----WLAIVSLAVLYNIIFVVGRAVFW--EINKSAPAFWYT-----LDYLCDFI 327
                   ||.     |..|:.|.|:|..:|....|.|.  |:..:|....:|     :|.:.|.:
 Worm   175 IHHCTIVHYSPFKAVWDWIILLLVIYTAVFTPYVAAFLLRELQDTAKKSRFTEPLEIVDLIVDIM 239

  Fly   328 YLLDTLVHMHEGFLDQG----LLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIWWPPETCSS 387
            :::|.:::....::::.    .:|.|..::..|||  |||: :|:::.:|.||..:....:..::
 Worm   240 FIVDIIINFRTTYVNENDEACQVVSDPGKIATHYF--KGWFIIDMVAAVPFDLLLVSTNSDETTT 302

  Fly   388 LYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLI-HWNACMYFAI-SYE 450
            |.    .:::..||||:.|:....||   .:.|..|  :..:::|...|| ||.||:::|| |.|
 Worm   303 LI----GLLKTARLLRLVRVARKLDR---YSEYGAA--VLLLLMATFALIAHWLACIWYAIGSAE 358

  Fly   451 IGFSSDSWVYNL-----------NG---TRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEY 500
            :.....:|::.|           ||   |...||:.:|:.|.|::..|:|:|| ...:...|.|.
 Worm   359 LSHKEYTWLHQLSKQLAQPYTSTNGTIPTGGPTLKSRYVTSLYFTLSTITSIGFGNVSATTDSEK 423

  Fly   501 LFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAY 565
            :|.:...:.|.|::|::.||:.::|..:......:...|..:::::.|.::.:.|..|:..:|.:
 Worm   424 IFTIIMMILGSLMYASVFGNVSAIIQRLYSGTARYHTEMSRLREFIRFHQIPNPLRQRLEEYFQH 488

  Fly   566 TWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDY 630
            .||.:..:|...||...||.|:|:|.:.::.:.|.....|..:.||.|.||.::.:.....|||.
 Worm   489 AWSYTNGIDMNLVLKGFPDCLQADICLHLNRNLLSGCAAFAGSTPGCLRALSMRFRTTHSPPGDT 553

  Fly   631 ICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVL--EIAGNRTGNRRTANVRSL 693
            :..:||:...:|.:.||.:.::.||. ||:..||...:|||..:|  |:      .:.:.|||:|
 Worm   554 LVHRGDILTGLYFIARGSVEILNDDN-TVMGILGKDDIFGENPLLYDEV------GKSSCNVRAL 611

  Fly   694 GYSDLFCLAKRDLWETLSDYPEARSTLTQR---------GCQLLRK 730
            .|.||..:.:.||.:.|..|||...|..:.         ..|.|||
 Worm   612 TYCDLHKILRDDLLDVLDMYPEFAETFCKNLTITYNLRDDAQSLRK 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	72/280 (26%)
		CAP_ED	604..717	CDD:237999	38/114 (33%)
		CLZ	720..790	CDD:465160	4/20 (20%)
unc-103	NP_001368173.1	PLN03192	190..>613	CDD:215625	115/440 (26%)