DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and tax-2

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_492427.3	Gene:	tax-2 / 172723	WormBaseID:	WBGene00006525	Length:	800	Species:	Caenorhabditis elegans

Alignment Length:	802	Identity:	234/802 - (29%)
Similarity:	364/802 - (45%)	Gaps:	177/802 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PLEEISGGLFAPFAPTATITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQD 138
            |..|.|..|..|    |..:.|.:|::.|         |.||..           |.|....:.|
Worm    43 PRSEDSFDLLDP----ANASKEPSASTRP---------LPYPPT-----------RPPEVVIQID 83

  Fly   139 EDEEEDDDDVDEDDDDEF-------------------GASVCEDNPEEAIA----RADHDTQQKQ 180
            |.|......:||.||.|.                   .:|:.||:....|:    ...|...::.
Worm    84 EVESPILGLIDETDDHELDGRLDPASSFDANSLSATRASSIIEDDVRSQISFIMRERLHSIAKEV 148

  Fly   181 HYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTD 245
            |.:.:|            ::|...|..|    ....::...:.|:|..:|....|....|.:.:.
Worm   149 HRRTSA------------VREDLIRETP----EDTVSMASNVPKQNEHRPSLMSLIGLQNRSESP 197

  Fly   246 KIG--KGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVF-- 306
            .:.  |.|       ....::|        :..|..:.:..||::|:|..|:|...:..|:.:
Worm   198 TVDTVKNC-------FGFSLKG--------TFHPYGRFYMTWLSLVTLCFLFNAFCIPLRSSYPY 247

  Fly   307 -----WEINKSAPAFWYTLDYLCDFIYLLD-TLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYL 365
                 |       .:|:.:||.||.:|::| .|:.....|...|:.|:.....:|||..|:.:.|
Worm   248 QTADNW-------MYWFIVDYSCDLVYVIDMLLIKPRLRFTRGGIQVKIYKDTQRHYLMTRTFKL 305

  Fly   366 DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVV 430
            |:||:|||||.|.::..       :|   |.|:||:|:||..|..||..:.:...|.|.||.:.:
Worm   306 DILSILPTDLMYFFFGK-------MP---IWRINRVLKINSFWLLFDMLDNSFANPYAIRIARTL 360

  Fly   431 LAILVLIHWNACMYFAISYEIGFSS-----------DSWVYNLNGTRNNTLQRQYIYSFYWSTLT 484
            ..::.:||.|:|:|:.:|....|..           :.||||..|       ..||..||::...
Worm   361 SYMIYIIHCNSCVYYKLSALQAFGQIAYLENGKWYLNKWVYNNQG-------NAYIRCFYFTAAV 418

  Fly   485 LTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAF- 548
            .|:.|..|.|.|.:||:::...::.||.:||.::|.|..::||.|..|.|||.:||     :|.
Worm   419 ATSTGNNPAPTNVIEYIYMTCSWMMGVFVFALLLGQIRDIVSNANRNREEFQRKMD-----LALG 478

  Fly   549 --RRVGHELEA--RVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTE 609
              :::|.::|.  ||..||.|||.|...|||::::..||.||:.::|:.||..||.:|::|.|.:
Worm   479 ECKKLGLKMETTNRVRDWFIYTWQQQKTLDEKKLIEKLPLKLQTDLALSVHYTTLSKVQLFQDCD 543

  Fly   610 PGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV-GDDGITVLATLGAGSVFGEVS 673
            ..||..|||||:..:|.|||.||.||||||||||:.:|.|.|| ||....:.|.|..|:||||:|
Worm   544 RALLRDLVLKLRPVIFLPGDMICLKGDVGKEMYIINQGILQVVGGDHNEKIFAELAQGAVFGEIS 608

  Fly   674 VLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQI 738
            :|.|.||   |||||::|:.||..||.|||.||.:.:..||:|::.|.::...:|:.|...||:
Worm   609 LLAIGGN---NRRTASIRAKGYCTLFVLAKEDLNDVIRYYPQAQTILRRKAAAMLKNDKKSDEK- 669

  Fly   739 FADSQRVHDSIEGGIEKLELSVE-----NLNMR----LARLLAEYTASQAKIKQRLAKLEMNGGP 794
                          .||::...|     .:|.|    |..|:|..|             |||...
Worm   670 --------------TEKIKAQAELEDRCKINPRQVPKLITLIANMT-------------EMNENK 707

  Fly   795 GTWRLEC---EPQSRARSGRLY 813
            |...|:.   |...::|...:|
Worm   708 GVQELKKVIEEETEKSRRQSIY 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	71/231 (31%)
		Ion_trans_2	<477..527	CDD:285168	15/49 (31%)
		Crp	598..>722	CDD:223736	65/124 (52%)
		CAP_ED	604..717	CDD:237999	60/113 (53%)
		CLZ	720..791	CDD:293134	15/79 (19%)
tax-2	NP_492427.3	Ion_trans	221..467	CDD:366146	80/269 (30%)
tax-2	NP_492427.3	CAP_ED	538..652	CDD:237999	61/116 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920