Protein Alignment CngA and Kcnh7

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_006234331.1
• Gene: Kcnh7 / 170739
• RGDID: 621112
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 757
• Identity: 188/757 - (24%)
• Similarity: 325/757 - (42%)
• Gaps: 141/757 - (18%)

  Fly    84 APFAPTATITVEQAATSIPMA-VDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDD 147
            :|.....|..:.|.:...|:. :.|.:.| ..|:|.|.|.|               .|..:....
  Rat   209 SPSEADDTKALIQPSQCSPLVNISGPLDH-SSPKRQWDRLY---------------PDMLQSSSQ 257

  Fly   148 VDEDDDDEFGASVCEDNPEEAIARAD--HDTQQKQHYQPN------ASDSSYVENGRK------- 197
            :......|   |:|      :|.||.  ||.:....:..|      ||:    :|||.
  Rat   258 LTHSRSRE---SLC------SIRRASSVHDIEGFNVHPKNIFRDRHASE----DNGRNVKVSRSW 309

  Fly   198 LIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSE 262
            :...|....|.|.|..|..:...:.:..|  |.|...| .||: ..|:|.....|:.:...::.:
  Rat   310 MAGGPFNHIKSSLLGSTSDSNLNKYSTIN--KIPQLTL-NFSD-VKTEKKNTSPPSSDKTIIAPK 370

  Fly   263 IR----------------GSSVLCNRLSVDPTLQS----HYR-----WLAIVSLAVLYNIIFVVG 302
            ::                |:.||.......|.:..    ||.     |..::.|.|:|..||...
  Rat   371 VKERTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPY 435

  Fly   303 RAVFW----------EINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRH 356
            .|.|.          |...|.... ..:|.:.|.::::|.|::....:::|. .:|.|..::..|
  Rat   436 SAAFLLNDREEQKRRECGYSCSPL-NVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAVH 499

  Fly   357 YFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGY 420
            ||  |||:| |:::.:|.||.......:..::|.    .:::..||||:.|:....||   .:.|
  Rat   500 YF--KGWFLIDMVAAIPFDLLIFGSGSDETTTLI----GLLKTARLLRLVRVARKLDR---YSEY 555

  Fly   421 PNAFRICKVVLAILVLI-HWNACMYFAI-SYEIGFSSD--SWVYNLN---GTRNN--------TL 470
            ..|  :..:::.|..|| ||.||:::|| :.|..:.:|  .|:.:|.   |.|.|        ::
  Rat   556 GAA--VLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGTQIGKRYNDSDSSSGPSI 618

  Fly   471 QRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVE 534
            :.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......
  Rat   619 KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 683

  Fly   535 FQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTL 599
            :..:|..||:::.|.::.:.|..|:..:|.:.|:.:..:|...||...|:.|:|:|.:.::...|
  Rat   684 YHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL 748

  Fly   600 KQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLG 664
            :..:.|.....|.|.||.:|.|.....|||.:...|||...:|.:.||.:.::.||  .|:|.||
  Rat   749 QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDD--IVVAILG 811

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPE------ARSTLTQR 723
            ...:|||:..|.....::    .|:||:|.|.||..:.:.||.|.|..|||      ....||..
  Rat   812 KNDIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFN 872

  Fly   724 GCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKL---ELSVEN 762
                ||.:.       |.||.::|| ||...||   .||.|:
  Rat   873 ----LRHES-------AKSQSINDS-EGDTCKLRRRRLSFES 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	72/279 (26%)
		CAP_ED	604..717	CDD:237999	40/118 (34%)
		CLZ	720..790	CDD:465160	16/46 (35%)
Kcnh7	XP_006234331.1	PAS_9	38..134	CDD:463873
		Ion_trans	417..679	CDD:459842	70/273 (26%)
		CAP_ED	753..864	CDD:237999	40/116 (34%)