DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and Kcnh7

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_011237615.1	Gene:	Kcnh7 / 170738	MGIID:	2159566	Length:	1203	Species:	Mus musculus

Alignment Length:	834	Identity:	203/834 - (24%)
Similarity:	343/834 - (41%)	Gaps:	159/834 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NRRRPETESPKYGYNLSNRPMY---------RTTRLVGPASSAPAQLQLPCGSHQ----ATLGVA 71
            |...||..:|.......||.::         .|.|........|..:.:....|.    |.....
Mouse   137 NAATPERVNPILPVKTVNRKLFGFKFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFK 201

  Fly    72 PPPLEEISGGLFAPFAPTATITVEQAATSIPMA-VDGEVHHLHYPRRSWQRKYRQGIHRQPGGGA 135
            .|..|..|     |.....|..:.|.:...|:. :.|.:.| ..|:|.|.|.|
Mouse   202 SPTKESCS-----PSEADDTKALIQPSQCSPLVNISGPLDH-SSPKRQWDRLY------------ 248

  Fly   136 EQDEDEEEDDDDVDEDDDDEFGASVCEDNPEEAIARAD--HDTQQKQHYQPN------ASDSSYV 192
               .|..:....:......|   |:|      :|.||.  ||.:....:..|      ||:
Mouse   249 ---PDMLQSSSQLTHSRSRE---SLC------SIRRASSVHDIEGFSVHPKNIFRDRHASE---- 297

  Fly   193 ENGRK-------LIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKG 250
            :|||.       :...|....|.|.|..|..:...:.:..|  |.|...| .||: ..|:|....
Mouse   298 DNGRNVKVSRSWMAGGPFNHIKSSLLGSTSDSNLNKYSTIN--KIPQLTL-NFSD-VKTEKKNTS 358

  Fly   251 CPAMEDAALSSEIR----------------GSSVLCNRLSVDPTLQS----HYR-----WLAIVS 290
            .|:.:...::.:::                |:.||.......|.:..    ||.     |..::.
Mouse   359 PPSSDKTIIAPKVKERTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLIL 423

  Fly   291 LAVLYNIIFVVGRAVFW----------EINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQG- 344
            |.|:|..||....|.|.          |...|.... ..:|.:.|.::::|.|::....:::|.
Mouse   424 LLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPL-NVVDLIVDIMFIIDILINFRTTYVNQNE 487

  Fly   345 LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLW 408
            .:|.|..::..|||  |||:| |:::.:|.||.......:..::|.    .:::..||||:.|:.
Mouse   488 EVVSDPAKIAIHYF--KGWFLIDMVAAIPFDLLIFGSGSDETTTLI----GLLKTARLLRLVRVA 546

  Fly   409 EWFDRTETATGYPNAFRICKVVLAILVLI-HWNACMYFAI-SYEIGFSSD--SWVYNLN---GTR 466
            ...||   .:.|..|  :..:::.|..|| ||.||:::|| :.|..:.:|  .|:.:|.   |.|
Mouse   547 RKLDR---YSEYGAA--VLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGTQIGKR 606

  Fly   467 NN--------TLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIG 522
            .|        :::.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:|.||:.
Mouse   607 YNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS 671

  Fly   523 SMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLK 587
            ::|..:......:..:|..||:::.|.::.:.|..|:..:|.:.|:.:..:|...||...|:.|:
Mouse   672 AIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQ 736

  Fly   588 AEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV 652
            |:|.:.::...|:..:.|.....|.|.||.:|.|.....|||.:...|||...:|.:.||.:.::
Mouse   737 ADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL 801

  Fly   653 GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPE-- 715
            .||  .|:|.||...:|||:..|.....::    .|:||:|.|.||..:.:.||.|.|..|||
Mouse   802 KDD--IVVAILGKNDIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPEFS 860

  Fly   716 ----ARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKL---ELSVEN 762
                ....||..    ||.:.       |.||.|:|| ||...||   .||.|:
Mouse   861 DHFLTNLELTFN----LRHES-------AKSQSVNDS-EGDTGKLRRRRLSFES 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	61/237 (26%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	42/129 (33%)
		CAP_ED	604..717	CDD:237999	40/118 (34%)
		CLZ	720..791	CDD:293134	17/46 (37%)
Kcnh7	XP_011237615.1	PAS_9	29..134	CDD:379177
		Ion_trans	417..679	CDD:366146	70/273 (26%)
		CAP_ED	753..864	CDD:237999	40/116 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840