Protein Alignment CngA and Kcnh2

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_038597.2
• Gene: Kcnh2 / 16511
• MGIID: 1341722
• Length: 1162
• Species: Mus musculus
• Alignment Length: 944
• Identity: 214/944 - (22%)
• Similarity: 352/944 - (37%)
• Gaps: 228/944 - (24%)

  Fly    46 LVGPASSAPAQLQLPCGSHQATLGVAPPPLE----EISGGLFAPFAPTATITVEQAAT------- 99
            |.||.:...|..|:.    ||.||.....:|    ...|..|........:..|..|.
Mouse    69 LHGPRTQRRAAAQIA----QALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNF 129

  Fly   100 SIPMAVD---GEVHHLHY--PRRSW----------------------QRKYRQGIHRQPG--GGA 135
            .:.|..|   ...|..::  |..||                      :...|.|..|..|  |..
Mouse   130 EVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESSVRTGSMRSAGAPGAV 194

  Fly   136 EQDED--------EEEDDDDVDEDDDDEFGASVCED----------NPEEAIARADHDTQQKQHY 182
            ..|.|        |....|:|...|:...|....|:          :|..:| |..|.:.:.|..
Mouse   195 VVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPGSASPVASI-RGPHPSPRAQSL 258

  Fly   183 QPNASDSSYVENGRKLIQEPSKRSKPSALRRT----LQALRQRLTKRNRPKPP------------ 231
            .|:||.||.     .|.:..|:.|..|..|.:    ::|:|....    |.||
Mouse   259 NPDASGSSC-----SLARTRSRESCASVRRASSADDIEAMRAGAL----PPPPRHASTGAMHPLR 314

  Fly   232 --------DWFLEKFSNTTNTDKIG------KGCPAMEDAALSSEI--------------RGSSV 268
                    |..|.::...:...:|.      ||.|.:.......||              :.:.|
Mouse   315 SGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQV 379

  Fly   269 LCNRLSVDP--TLQS---------HYR-----WLAIVSLAVLYNIIFVVGRAVF----WEINKSA 313
            |.....|.|  .||:         ||.     |..::.|.|:|..:|....|.|    .|....|
Mouse   380 LSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQA 444

  Fly   314 PAFWY------TLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSM 370
            |...|      .:|.:.|.::::|.|::....:::.. .:|....|:..|||  |||:| |:::.
Mouse   445 PDCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYF--KGWFLIDMVAA 507

  Fly   371 LPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILV 435
            :|.||.......|....|       ::..||||:.|:....||............:|...|
Mouse   508 IPFDLLIFGSGSEELIGL-------LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL---- 561

  Fly   436 LIHWNACMYFAISYEIGFSSDS---WVYNL----------NGTRNNTLQRQYIYSFYWSTLTLTT 487
            :.||.||:::||........||   |::||          :|....:::.:|:.:.|::..:||:
Mouse   562 IAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTS 626

  Fly   488 IG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRV 551
            :| ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......:..:|..|::::.|.::
Mouse   627 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQI 691

  Fly   552 GHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEAL 616
            .:.|..|:..:|.:.||.:..:|...||...|:.|:|:|.:.::...|:..:.|.....|.|.||
Mouse   692 PNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRAL 756

  Fly   617 VLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGE-VSVLEIAGN 680
            .:|.|.....|||.:...||:...:|.:.||.:.::..|  .|:|.||...:||| :::....|.
Mouse   757 AMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGD--VVVAILGKNDIFGEPLNLYARPGK 819

  Fly   681 RTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFAD---- 741
            ..|     :||:|.|.||..:.:.||.|.|..|||                       |:|
Mouse   820 SNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE-----------------------FSDHFWS 856

  Fly   742 ------SQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAK-LEMNG-----GP 794
                  :.|..:.|.|.....||. ...|.:..|.|:        .::|..| .|..|     |.
Mouse   857 SLEITFNLRDTNMIPGSPGSAELE-SGFNRQRKRKLS--------FRRRTDKDTEQPGEVSALGQ 912

  Fly   795 GTWRLECEPQSRARSGRLYSLQPKRRPRSRPDAT 828
            |..|:...|..|.:.|..:...|...| |.|:::
Mouse   913 GPARVGPGPSCRGQPGGPWGESPSSGP-SSPESS 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	69/277 (25%)
		CAP_ED	604..717	CDD:237999	38/113 (34%)
		CLZ	720..790	CDD:465160	12/80 (15%)
Kcnh2	NP_038597.2	PRK13559	30..328	CDD:237427	55/272 (20%)
		PAS_9	38..130	CDD:463873	14/64 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	233..316		20/92 (22%)
		Ion_trans	411..670	CDD:459842	67/271 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472	626..631		1/4 (25%)
		CAP_ED	744..855	CDD:237999	40/140 (29%)
		cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060	744..844		34/106 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	873..991		19/83 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1125..1162