DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and Kcnh2

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_038597.2	Gene:	Kcnh2 / 16511	MGIID:	1341722	Length:	1162	Species:	Mus musculus

Alignment Length:	944	Identity:	214/944 - (22%)
Similarity:	352/944 - (37%)	Gaps:	228/944 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LVGPASSAPAQLQLPCGSHQATLGVAPPPLE----EISGGLFAPFAPTATITVEQAAT------- 99
            |.||.:...|..|:.    ||.||.....:|    ...|..|........:..|..|.
Mouse    69 LHGPRTQRRAAAQIA----QALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNF 129

  Fly   100 SIPMAVD---GEVHHLHY--PRRSW----------------------QRKYRQGIHRQPG--GGA 135
            .:.|..|   ...|..::  |..||                      :...|.|..|..|  |..
Mouse   130 EVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESSVRTGSMRSAGAPGAV 194

  Fly   136 EQDED--------EEEDDDDVDEDDDDEFGASVCED----------NPEEAIARADHDTQQKQHY 182
            ..|.|        |....|:|...|:...|....|:          :|..:| |..|.:.:.|..
Mouse   195 VVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPGSASPVASI-RGPHPSPRAQSL 258

  Fly   183 QPNASDSSYVENGRKLIQEPSKRSKPSALRRT----LQALRQRLTKRNRPKPP------------ 231
            .|:||.||.     .|.:..|:.|..|..|.:    ::|:|....    |.||
Mouse   259 NPDASGSSC-----SLARTRSRESCASVRRASSADDIEAMRAGAL----PPPPRHASTGAMHPLR 314

  Fly   232 --------DWFLEKFSNTTNTDKIG------KGCPAMEDAALSSEI--------------RGSSV 268
                    |..|.::...:...:|.      ||.|.:.......||              :.:.|
Mouse   315 SGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQV 379

  Fly   269 LCNRLSVDP--TLQS---------HYR-----WLAIVSLAVLYNIIFVVGRAVF----WEINKSA 313
            |.....|.|  .||:         ||.     |..::.|.|:|..:|....|.|    .|....|
Mouse   380 LSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQA 444

  Fly   314 PAFWY------TLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSM 370
            |...|      .:|.:.|.::::|.|::....:::.. .:|....|:..|||  |||:| |:::.
Mouse   445 PDCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYF--KGWFLIDMVAA 507

  Fly   371 LPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILV 435
            :|.||.......|....|       ::..||||:.|:....||............:|...|
Mouse   508 IPFDLLIFGSGSEELIGL-------LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL---- 561

  Fly   436 LIHWNACMYFAISYEIGFSSDS---WVYNL----------NGTRNNTLQRQYIYSFYWSTLTLTT 487
            :.||.||:::||........||   |::||          :|....:::.:|:.:.|::..:||:
Mouse   562 IAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTS 626

  Fly   488 IG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRV 551
            :| ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......:..:|..|::::.|.::
Mouse   627 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQI 691

  Fly   552 GHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEAL 616
            .:.|..|:..:|.:.||.:..:|...||...|:.|:|:|.:.::...|:..:.|.....|.|.||
Mouse   692 PNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRAL 756

  Fly   617 VLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGE-VSVLEIAGN 680
            .:|.|.....|||.:...||:...:|.:.||.:.::..|  .|:|.||...:||| :::....|.
Mouse   757 AMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGD--VVVAILGKNDIFGEPLNLYARPGK 819

  Fly   681 RTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFAD---- 741
            ..|     :||:|.|.||..:.:.||.|.|..|||                       |:|
Mouse   820 SNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE-----------------------FSDHFWS 856

  Fly   742 ------SQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAK-LEMNG-----GP 794
                  :.|..:.|.|.....||. ...|.:..|.|:        .::|..| .|..|     |.
Mouse   857 SLEITFNLRDTNMIPGSPGSAELE-SGFNRQRKRKLS--------FRRRTDKDTEQPGEVSALGQ 912

  Fly   795 GTWRLECEPQSRARSGRLYSLQPKRRPRSRPDAT 828
            |..|:...|..|.:.|..:...|...| |.|:::
Mouse   913 GPARVGPGPSCRGQPGGPWGESPSSGP-SSPESS 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	59/241 (24%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	39/124 (31%)
		CAP_ED	604..717	CDD:237999	38/113 (34%)
		CLZ	720..791	CDD:293134	13/81 (16%)
Kcnh2	NP_038597.2	PAS_9	29..130	CDD:290162	14/64 (22%)
		PAS	41..132	CDD:238075	14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..316		20/92 (22%)
		Ion_trans	451..670	CDD:278921	56/231 (24%)
		Ion_trans_2	<613..667	CDD:285168	16/53 (30%)
		Selectivity filter. /evidence=ECO:0000250	626..631		1/4 (25%)
		Crp	738..>858	CDD:223736	41/149 (28%)
		CAP_ED	744..855	CDD:237999	40/140 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..991		19/83 (23%)
		SSTK-IP	1015..1116	CDD:292464
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840