DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and Hcn3

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_032253.1	Gene:	Hcn3 / 15168	MGIID:	1298211	Length:	779	Species:	Mus musculus

Alignment Length:	603	Identity:	155/603 - (25%)
Similarity:	266/603 - (44%)	Gaps:	97/603 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 VDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEG 339
            :.|.....:.|..|:.|.::.|:|.:.....|::...|.|  |...:.|.|..:|||.:::...|
Mouse    85 IHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP--WIVFNVLSDTFFLLDLVLNFRTG 147

  Fly   340 F-LDQG---LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAY--IWWPPETCSSLYLPCPV--- 394
            . :::|   ||...|.|.|  |..|  |:| |::|.:|.|..:  :...|...:.:|.....
Mouse   148 IVVEEGAEILLAPRAIRTR--YLRT--WFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRI 208

  Fly   395 -----IVRLNRLLRINRL------WE-----WFDRTETATGYPNAFRICKVVLAILVLIHWNACM 443
                 |:.|.||||::||      ||     .:|......      ||..::..:|:|.||:.|:
Mouse   209 VRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV------RIFNLIGMMLLLCHWDGCL 267

  Fly   444 YFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG---ETPTPENDVEYLFVVA 505
            .|.:.....|.||.|| ::|...|::..|||.::.:.:...:..||   :.|....||  ...:.
Mouse   268 QFLVPMLQDFPSDCWV-SMNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDV--WLTML 329

  Fly   506 DFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQS 570
            ..:.|...:|..:|:..::|.:::.:|.::|.:...|:|||:|.::..:...|:..::.:.: |.
Mouse   330 SMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QG 393

  Fly   571 GALDEERVLAALPDKLKAEI------AIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGD 629
            ...|||.:|..|.:.|:.||      .:..||.      :|...:|..:.|::.||:.:||.|||
Mouse   394 KMFDEESILGELSEPLREEIINFTCRGLVAHMP------LFAHADPSFVTAVLTKLRFEVFQPGD 452

  Fly   630 YICRKGDVGKEMYIVKRGKLSVVG----DDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANV 690
            .:.|:|.||::||.::.|.|||:.    |..:|      .||.|||:.:|      |..||||:|
Mouse   453 LVVREGSVGRKMYFIQHGLLSVLARGARDTRLT------DGSYFGEICLL------TRGRRTASV 505

  Fly   691 RSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEK 755
            |:..|..|:.|:.......|.::|..|..........||:.|..:..:............||:.:
Mouse   506 RADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSEPSPGSSGGVME 570

  Fly   756 LELSVENLNM-RLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRA-------RSGRL 812
            ..|...:.:| |..|.||..|.::           ::|.|..|    ||...|       .|...
Mouse   571 QHLVQHDRDMARGVRGLAPGTGAR-----------LSGKPVLW----EPLVHAPLQAAAVTSNVA 620

  Fly   813 YSLQPKRRPRS-RPDATA 829
            .:|..:|.|.. .||:.|
Mouse   621 IALTHQRGPLPLSPDSPA 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	63/248 (25%)
		Ion_trans_2	<477..527	CDD:285168	9/52 (17%)
		Crp	598..>722	CDD:223736	41/127 (32%)
		CAP_ED	604..717	CDD:237999	40/116 (34%)
		CLZ	720..791	CDD:293134	12/71 (17%)
Hcn3	NP_032253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		1/4 (25%)
		Ion_trans_N	48..90	CDD:312050	1/4 (25%)
		Ion_trans	92..357	CDD:306908	69/279 (25%)
		Interaction with KCTD3. /evidence=ECO:0000269\|PubMed:23382386	353..779		85/320 (27%)
		CAP_ED	427..535	CDD:237999	41/119 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..569		2/19 (11%)
		Atrophin-1	<585..773	CDD:331285	17/69 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..779
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840