Protein Alignment CngA and Hcn2

DIOPT Version :9

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_032252.1
• Gene: Hcn2 / 15166
• MGIID: 1298210
• Length: 863
• Species: Mus musculus
• Alignment Length: 540
• Identity: 137/540 - (25%)
• Similarity: 262/540 - (48%)
• Gaps: 61/540 - (11%)

  Fly   275 VDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEG 339
            :.|.....:.|...:.|.::.|:|.:.....|::...:||  |...:.:.|..:|:|.:::...|
Mouse   177 IHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP--WIVFNVVSDTFFLMDLVLNFRTG 239

  Fly   340 FL--DQGLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPV------- 394
            .:  |...::.|..::::.|..|  |: :|.:|.:|.|..::.......|.:|.....
Mouse   240 IVIEDNTEIILDPEKIKKKYLRT--WFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFT 302

  Fly   395 -IVRLNRLLRINRL------W-EWFDRT-ETATGYPNAFRICKVVLAILVLIHWNACMYFAISYE 450
             |:.|.||||::||      | |.|..| :.|:.   ..|||.::..:|:|.||:.|:.|.:...
Mouse   303 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA---VMRICNLISMMLLLCHWDGCLQFLVPML 364

  Fly   451 IGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIF 514
            ..|.||.|| ::|...|::....|.::.:.:...:..|| ....||:..:....:...:.|...:
Mouse   365 QDFPSDCWV-SINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCY 428

  Fly   515 ATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVL 579
            |..:|:..::|.:::.:|.::|.:...|:|||:|.::..:...::..::.:.: |....||:.:|
Mouse   429 AMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSIL 492

  Fly   580 AALPDKLKAEIAIQVHMDTLKQVR---IFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEM 641
            ..|...|:.||   |:.:..|.|.   :|.:.:|..:.|::.|||.:||.|||||.|:|.:||:|
Mouse   493 GELNGPLREEI---VNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKM 554

  Fly   642 YIVKRGKLSVV--GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKR 704
            |.::.|.:||:  |:..:    .|..||.|||:.:|      |..||||:||:..|..|:.|:..
Mouse   555 YFIQHGVVSVLTKGNKEM----KLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVD 609

  Fly   705 DLWETLSDYPEAR----STLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNM 765
            :..|.|.:||..|    :....|..::.:|:.:|..::      .||...|.....|.::....:
Mouse   610 NFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKV------QHDLSSGVFNNQENAIIQEIV 668

  Fly   766 RLARLLAEYTASQAKIKQRL 785
            :..|.:.:    ||::.||:
Mouse   669 KYDREMVQ----QAELGQRV 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	56/239 (23%)
		Ion_trans_2	<477..527	CDD:285168	8/50 (16%)
		Crp	598..>722	CDD:223736	47/132 (36%)
		CAP_ED	604..717	CDD:237999	44/114 (39%)
		CLZ	720..791	CDD:293134	12/66 (18%)
Hcn2	NP_032252.1	CAP_ED	517..625	CDD:237999	45/117 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	730..863
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131
		Involved in subunit assembly	131..182		1/4 (25%)
		Ion_trans_N	140..182	CDD:285597	1/4 (25%)
		Ion_trans	202..447	CDD:278921	57/252 (23%)
		Crp	511..>646	CDD:223736	49/144 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840