DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngA and KCNH8

DIOPT Version :9

Sequence 1:NP_001188960.1 Gene:CngA / 36806 FlyBaseID:FBgn0261612 Length:840 Species:Drosophila melanogaster
Sequence 2:XP_016861187.1 Gene:KCNH8 / 131096 HGNCID:18864 Length:1108 Species:Homo sapiens


Alignment Length:584 Identity:150/584 - (25%)
Similarity:267/584 - (45%) Gaps:109/584 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 ASDSSYVENGRKLIQEPSKRSK-----------PSALRRT---LQALRQRLTKRNRPKPPDWFLE 236
            ||.....:...|:..|..|..|           .||.||:   |..:...|.:|.:.|      .
Human   128 ASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNK------L 186

  Fly   237 KFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAI-----VSLAVLYN 296
            |.:|....||     ||..:..:|...:...:|.:    ..|.::.:.||.:     |::.|.||
Human   187 KINNNVFVDK-----PAFPEYKVSDAKKSKFILLH----FSTFKAGWDWLILLATFYVAVTVPYN 242

  Fly   297 IIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHT 360
            :.|:      ...:.|........|...:.::::|.:::....::.: |.::.:|..:..||..|
Human   243 VCFI------GNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTT 301

  Fly   361 KGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDR-TETATGYPNA 423
              |: :|:::.||.||.|.:  ..|..||.    .:::..||||:.||.:..|| ::.:|     
Human   302 --WFIIDLIAALPFDLLYAF--NVTVVSLV----HLLKTVRLLRLLRLLQKLDRYSQHST----- 353

  Fly   424 FRICKVVLAIL-----VLIHWNACMYFAI-----------SYEIGFSSDSWVYNLNGTR------ 466
                 :||.:|     :|.||.||:::.|           .:|:|     |::.| |.|      
Human   354 -----IVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVG-----WLHEL-GKRLESPYY 407

  Fly   467 -NNTL-----QRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSM 524
             ||||     :..||.:.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.::
Human   408 GNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAI 472

  Fly   525 ISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAE 589
            |..|......:..|...:|.::....:..:|:.|::.:|..|||.:..:|...:|...||:|:::
Human   473 IQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD 537

  Fly   590 IAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGD 654
            |.:.::.:.| |:.:|.....|.|.:|.|.:|....:||:|:.|:||..:.:|.|..|.:.|:.|
Human   538 ITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKD 601

  Fly   655 DGITVLATLGAGSVFG-EVSVLE--IAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPE 715
            .  .|||.||.|.:.| .:|:.:  |..|       |:|::|.|.||.|:..:.|:|.|..|||
Human   602 S--MVLAILGKGDLIGANLSIKDQVIKTN-------ADVKALTYCDLQCIILKGLFEVLDLYPE 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngANP_001188960.1 Ion_trans 309..529 CDD:278921 63/251 (25%)
Ion_trans_2 <477..527 CDD:285168 15/50 (30%)
Crp 598..>722 CDD:223736 42/121 (35%)
CAP_ED 604..717 CDD:237999 40/115 (35%)
CLZ 720..791 CDD:293134
KCNH8XP_016861187.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145015
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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