DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and Cnga3

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001268939.1	Gene:	Cnga3 / 12790	MGIID:	1341818	Length:	669	Species:	Mus musculus

Alignment Length:	649	Identity:	326/649 - (50%)
Similarity:	420/649 - (64%)	Gaps:	41/649 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 AIARADHDTQQKQH-----YQPNASDSSYVENGRKLIQEP-----SKRS-----KPSALRRTLQA 217
            :|..||.|....::     :.|....||.::.|  :..|.     |.||     .|:.:.|.:.:
Mouse    17 SIKNADRDLDHVENGLGRSHSPCEETSSTLQQG--IAMETRGLAGSARSVVTSQGPARVSRLIIS 79

  Fly   218 LRQRLTK--RNRPKPPDWFLEKF-----SNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSV 275
            :|...::  .:..:.||.||::|     ...:..:...:..|..:......|.|....:.    |
Mouse    80 IRAWASRHLHDEDQTPDSFLDRFHGSELKEVSTRESNAQPNPGEQKPPDGGEGRKEEPIV----V 140

  Fly   276 DPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGF 340
            ||:...:||||..::|.|.||...:|.||.|.|:.......|..|||..|.:|:||.||....||
Mouse   141 DPSSNIYYRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADVLYVLDMLVRARTGF 205

  Fly   341 LDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRIN 405
            |:|||:|||..||.:||..|..:.||:||::||||||:        .|.:..|.: |.||||:.:
Mouse   206 LEQGLMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAYL--------KLGVNYPEL-RFNRLLKFS 261

  Fly   406 RLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVY-NLNGTRNNT 469
            ||:|:||||||.|.|||.|||..:||..|::||||||:|||||..|||.:||||| |.:......
Mouse   262 RLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYAR 326

  Fly   470 LQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVE 534
            |.|:||||.||||||||||||||.|..|.||||||.|||.|:|||||||||:||||||||..|||
Mouse   327 LSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGILIFATIVGNVGSMISNMNAPRVE 391

  Fly   535 FQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTL 599
            ||.::|.|||||.||:|..:||.||||||.|.|:....:||:.||..|||||||||||.||:|||
Mouse   392 FQAKIDSVKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTL 456

  Fly   600 KQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLG 664
            |:||||.|.|.|||..|||||:..|||||||||:|||:|:||||:|.|||:||.|||:|....|.
Mouse   457 KKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS 521

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR 729
            .||.|||:|:|.|.|:::|||||||:||:||||||||:|.||.|.|::||:|:..|.::|.|:|.
Mouse   522 DGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKRALEEKGRQILM 586

  Fly   730 KDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLE--MN 791
            ||.|:||.:.|......| :|..:|.||.|::.|..|.|||||||:|||.|:||||.:||  ||
Mouse   587 KDNLIDEDLVAARVDTRD-VEEKVEYLESSLDILQTRFARLLAEYSASQMKLKQRLTRLESQMN 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	127/220 (58%)
		Ion_trans_2	<477..527	CDD:285168	40/49 (82%)
		Crp	598..>722	CDD:223736	80/123 (65%)
		CAP_ED	604..717	CDD:237999	73/112 (65%)
		CLZ	720..791	CDD:293134	35/72 (49%)
Cnga3	NP_001268939.1	Ion_trans	165..387	CDD:278921	133/230 (58%)
		Radical_SAM	422..>475	CDD:302752	33/52 (63%)
		Crp	455..>577	CDD:223736	79/121 (65%)
		CAP_ED	461..577	CDD:237999	74/115 (64%)
		CLZ	577..647	CDD:293134	35/70 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835117
Domainoid	1	1.000	269	1.000	Domainoid score	I1829
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H994
Inparanoid	1	1.050	586	1.000	Inparanoid score	I993
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48384
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	1	1.000	-	-		otm43647
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2458
SonicParanoid	1	1.000	-	-		X511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790