Protein Alignment CngA and CNGA3

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 331/687 - (48%)
• Similarity: 422/687 - (61%)
• Gaps: 101/687 - (14%)

  Fly   145 DDDVDEDDDDEFGASVCEDNPEEAIAR---------ADHDTQQKQHYQPNASD------------ 188
            :|..||.:....|:..|...|:..::|         |.|     .|:|....|
Human   104 EDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARH-----VHHQDQGPDSFPDRFRGAELK 163

  Fly   189 --SSYVENGRKLI--QEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEK----FSNTTNTD 245
              ||...|.:..:  |||:.|.:.:                       |.|.|    .||.|..:
Human   164 EVSSQESNAQANVGSQEPADRGRSA-----------------------WPLAKCNTNTSNNTEEE 205

  Fly   246 KIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEIN 310
            |..|    .:||               :.|||:...:||||..::|.|.||...::.||.|.|:.
Human   206 KKTK----KKDA---------------IVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQ 251

  Fly   311 KSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDL 375
            ......|..|||..|.:|:||.||....|||:|||:|.|..||.:||..|..:.|||||::||||
Human   252 SEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDL 316

  Fly   376 AYIWWP---PETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLI 437
            ||:...   ||            ||.||||:.:||:|:||||||.|.|||.|||..:||.||::|
Human   317 AYLKVGTNYPE------------VRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII 369

  Fly   438 HWNACMYFAISYEIGFSSDSWVY-NLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYL 501
            |||||:|||||..|||.:||||| |::...:..|.|:||||.||||||||||||||.|..|.|||
Human   370 HWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYL 434

  Fly   502 FVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYT 566
            |||.|||.|||||||||||:||||||||.:|.|||.::|.:||||.||:|..:||.||||||.|.
Human   435 FVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYL 499

  Fly   567 WSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYI 631
            |:....:||:.||.:|||||||||||.||:||||:||||.|.|.|||..|||||:..||||||||
Human   500 WANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYI 564

  Fly   632 CRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYS 696
            |:|||:||||||:..|||:||.|||:|....|..||.|||:|:|.|.|:::|||||||:||:|||
Human   565 CKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYS 629

  Fly   697 DLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIF---ADSQRVHDSIEGGIEKLEL 758
            |||||:|.||.|.|::||||:..|.::|.|:|.||.|:||::.   ||.:    .:|..:|:|..
Human   630 DLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPK----DLEEKVEQLGS 690

  Fly   759 SVENLNMRLARLLAEYTASQAKIKQRLAKLE--MNGG 793
            |::.|..|.|||||||.|:|.|:||||::||  :.||
Human   691 SLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGG 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	142/250 (57%)
		CAP_ED	604..717	CDD:237999	74/112 (66%)
		CLZ	720..790	CDD:465160	33/74 (45%)
CNGA3	XP_011508856.1	Ion_trans	223..465	CDD:459842	144/253 (57%)
		CAP_ED	537..653	CDD:237999	75/115 (65%)
		CLZ	653..722	CDD:465160	32/72 (44%)