Protein Alignment CngA and CNGA1

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_005248106.3
• Gene: CNGA1 / 1259
• HGNCID: 2148
• Length: 690
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 316/710 - (44%)
• Similarity: 428/710 - (60%)
• Gaps: 68/710 - (9%)

  Fly    92 ITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDDVDEDDDDEF 156
            |..:|:..::|..:..::              .:.|.|...|..   ....||||.....::.|
Human    10 INTQQSFVTMPNVIVPDI--------------EKEIRRMENGAC---SSFSEDDDSASTSEESE- 56

  Fly   157 GASVCEDNPEEAIARADHD--------TQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRR 213
                 .:||.   ||....        ..|::.|.|.|.....|.|.....|||.::.|....::
Human    57 -----NENPH---ARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKK 113

  Fly   214 TLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPT 278
            :    :......|:..|     ||.....:.:|..|    .|.:....|.....|:.    :||:
Human   114 S----KSDDKNENKNDP-----EKKKKKKDKEKKKK----EEKSKDKKEEEKKEVVV----IDPS 161

  Fly   279 LQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ 343
            ..::|.||..::|.|:||...|:.||.|.|:......:|..|||:.|.:||:|..|....|:|:|
Human   162 GNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQ 226

  Fly   344 GLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYI---WWPPETCSSLYLPCPVIVRLNRLLRIN 405
            ||||::..:|...|.....:.|||||::||||.|.   |..||            :|||||||.:
Human   227 GLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE------------IRLNRLLRFS 279

  Fly   406 RLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVY-NLNGTRNNT 469
            |::|:|.||||.|.|||.|||..:|:.|:::||||||::::||..|||.:|:||| ::|......
Human   280 RMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGR 344

  Fly   470 LQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVE 534
            |.|:|:||.||||||||||||||.|..|.||:|||.|||.||||||||||||||||||||.||.|
Human   345 LARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAE 409

  Fly   535 FQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTL 599
            ||.|:|.:||||.||.|..::|.|||:||.|.|:....:||:.||..|||||:|||||.||:|||
Human   410 FQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 474

  Fly   600 KQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLG 664
            |:||||.|.|.|||..|||||:.||:|||||||:|||:|:||||:|.|||:||.|||:|....|.
Human   475 KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLS 539

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR 729
            .||.|||:|:|.|.|::.|||||||::|:||||||||:|.||.|.|::||:|::.|.::|.|:|.
Human   540 DGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILM 604

  Fly   730 KDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLE 789
            ||||||..| |::......:|..:.::|.||:.|..|.||:||||.:.|.|:||||.|:|
Human   605 KDGLLDLNI-ANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVE 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	129/250 (52%)
		CAP_ED	604..717	CDD:237999	72/112 (64%)
		CLZ	720..790	CDD:465160	32/70 (46%)
CNGA1	XP_005248106.3	Ion_trans	165..407	CDD:459842	131/253 (52%)
		CAP_ED	479..595	CDD:237999	73/115 (63%)
		CLZ	595..664	CDD:465160	32/70 (46%)