DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and CNGB1

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001288.3	Gene:	CNGB1 / 1258	HGNCID:	2151	Length:	1251	Species:	Homo sapiens

Alignment Length:	806	Identity:	217/806 - (26%)
Similarity:	360/806 - (44%)	Gaps:	178/806 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VAPPPLEEISGGLFAPFAPTATITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQ--PG 132
            |.|||         :| |.:.|:.|..:|:                          |.||:  |.
Human   489 VLPPP---------SP-AKSDTLIVPSSAS--------------------------GTHRKKLPS 517

  Fly   133 GGAEQDEDEEEDDDDVDEDDDDEFGASVCEDNPEEAIARAD----HDTQQKQHYQPNASDSSYVE 193
                            ::|:.:|..|....::|  .:|.:|    .||..:......||.:|.:.
Human   518 ----------------EDDEAEELKALSPAESP--VVAWSDPTTPKDTDGQDRAASTASTNSAII 564

  Fly   194 NGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAME--- 255
            |.|  :||..|..|    .|| :.::::|.      .||        .|:.::..|..||.:
Human   565 NDR--LQELVKLFK----ERT-EKVKEKLI------DPD--------VTSDEESPKPSPAKKAPE 608

  Fly   256 --------DAALSSEIRGSSVLCNRL------------SVDPTLQSHY-RWLAIVSLAVLYNIIF 299
                    :|....|.....:||.:.            |:||.....| .||..|.:|..:|...
Human   609 PAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWL 673

  Fly   300 VVGRAVFWEINKSAP---AFWYTLDYLCDFIYLLD-TLVHMHEGFLDQGLLVRDAFRLRRHYFHT 360
            :   .|.|......|   ..|..:|||||.||.|| |:......|:..|.::.|...:|.:|..:
Human   674 I---PVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKS 735

  Fly   361 KGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPV--IVRLNRLLRINRLWEWFDRTETATGYPNA 423
            :.:.:|:||:||.|.            |||...|  ::||.|.|:....:|:..|.|:.......
Human   736 RRFKMDLLSLLPLDF------------LYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYV 788

  Fly   424 FRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTI 488
            :|:.:....:|..:|.|:|:|:..|...|..|..|||  :|..|:     ||..:|::..||.||
Human   789 YRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVY--DGVGNS-----YIRCYYFAVKTLITI 846

  Fly   489 GETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGH 553
            |..|.|:...|.:|.:.::..||..|:.::|.:..::......:..:::.||...:||.|.::..
Human   847 GGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPK 911

  Fly   554 ELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVL 618
            .::.||..|:.|||...|.|||..::..||||::.::||.|:.:.:.:|.:|...:..::..::.
Human   912 SVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLK 976

  Fly   619 KLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV-GDDGITVLATLGAGSVFGEVSVLEIAGNRT 682
            :|:..|:.|.||:|:||::|:||||::.|::.|: |.||.:||.||.|||||||:|:|.:.|
Human   977 RLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG--- 1038

  Fly   683 GNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHD 747
            ||||||||.:.|:::||.|.|:||.|.|..|||::..|.::..::||.:..
Human  1039 GNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNK-------------- 1089

  Fly   748 SIEGGIEKLELSVENLNMRLARLLAEYTASQAKI-KQRLAKLEMNGGPGTWRLECEPQSRARSGR 811
                  .|.|.||         |:....|...|: ...||.....||.|           |:.|:
Human  1090 ------PKEEKSV---------LILPPRAGTPKLFNAALAMTGKMGGKG-----------AKGGK 1128

  Fly   812 LYSLQPKRRPRSRPDATAKSSDAAKQ 837
            |..|:.:.:..:..:|.||..:..:|
Human  1129 LAHLRARLKELAALEAAAKQQELVEQ 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	64/225 (28%)
		Ion_trans_2	<477..527	CDD:285168	14/49 (29%)
		Crp	598..>722	CDD:223736	55/124 (44%)
		CAP_ED	604..717	CDD:237999	53/113 (47%)
		CLZ	720..791	CDD:293134	12/71 (17%)
CNGB1	NP_001288.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..151
		Trypan_PARP	<171..257	CDD:114603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..252
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..561		23/125 (18%)
		IQ-like	568..578		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..619		7/47 (15%)
		Ion_trans	674..881	CDD:278921	66/228 (29%)
		Crp	956..>1093	CDD:223736	58/159 (36%)
		CAP_ED	962..1071	CDD:237999	51/111 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1251		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850