Protein Alignment CngA and Kcnh2

DIOPT Version :9

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_006235929.2
• Gene: Kcnh2 / 117018
• RGDID: 621414
• Length: 1234
• Species: Rattus norvegicus
• Alignment Length: 944
• Identity: 215/944 - (22%)
• Similarity: 351/944 - (37%)
• Gaps: 228/944 - (24%)

  Fly    46 LVGPASSAPAQLQLPCGSHQATLGVAPPPLE----EISGGLFAPFAPTATITVEQAAT------- 99
            |.||.:...|..|:.    ||.||.....:|    ...|..|........:..|..|.
  Rat   140 LHGPRTQRRAAAQIA----QALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNF 200

  Fly   100 SIPMAVD---GEVHHLHY--PRRSW----------------------QRKYRQGIHRQPG--GGA 135
            .:.|..|   ...|..::  |..||                      :...|.|....||  |..
  Rat   201 EVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAV 265

  Fly   136 EQDED--------EEEDDDDVDEDDDDEFGASVCED----------NPEEAIARADHDTQQKQHY 182
            ..|.|        |....|:|...|:...|....|:          :|..:| |..|.:...|..
  Rat   266 VVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASI-RGPHPSPPAQSL 329

  Fly   183 QPNASDSSYVENGRKLIQEPSKRSKPSALRRT----LQALRQRLTKRNRPKPP------------ 231
            .|:||.||.     .|.:..|:.|..|..|.:    ::|:|....    |.||
  Rat   330 NPDASGSSC-----SLARTRSRESCASVRRASSADDIEAMRAGAL----PPPPRHASTGAMHPLR 385

  Fly   232 --------DWFLEKFSNTTNTDKIG------KGCPAMEDAALSSEI--------------RGSSV 268
                    |..|.::...:...:|.      ||.|.:.......||              :.:.|
  Rat   386 SGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQV 450

  Fly   269 LCNRLSVDP--TLQS---------HYR-----WLAIVSLAVLYNIIFVVGRAVF----WEINKSA 313
            |.....|.|  .||:         ||.     |..::.|.|:|..:|....|.|    .|....|
  Rat   451 LSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQA 515

  Fly   314 PAFWY------TLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSM 370
            |...|      .:|.|.|.::::|.|::....:::.. .:|....|:..|||  |||:| |:::.
  Rat   516 PDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYF--KGWFLIDMVAA 578

  Fly   371 LPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILV 435
            :|.||.......|....|       ::..||||:.|:....||............:|...|
  Rat   579 IPFDLLIFGSGSEELIGL-------LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL---- 632

  Fly   436 LIHWNACMYFAISYEIGFSSDS---WVYNL----------NGTRNNTLQRQYIYSFYWSTLTLTT 487
            :.||.||:::||........||   |::||          :|....:::.:|:.:.|::..:||:
  Rat   633 IAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTS 697

  Fly   488 IG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRV 551
            :| ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......:..:|..|::::.|.::
  Rat   698 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQI 762

  Fly   552 GHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEAL 616
            .:.|..|:..:|.:.||.:..:|...||...|:.|:|:|.:.::...|:..:.|.....|.|.||
  Rat   763 PNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRAL 827

  Fly   617 VLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGE-VSVLEIAGN 680
            .:|.|.....|||.:...||:...:|.:.||.:.::..|  .|:|.||...:||| :::....|.
  Rat   828 AMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGD--VVVAILGKNDIFGEPLNLYARPGK 890

  Fly   681 RTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFAD---- 741
            ..|     :||:|.|.||..:.:.||.|.|..|||                       |:|
  Rat   891 SNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE-----------------------FSDHFWS 927

  Fly   742 ------SQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAK-LEMNG-----GP 794
                  :.|..:.|.|.....||. ...|.:..|.|:        .::|..| .|..|     |.
  Rat   928 SLEITFNLRDTNMIPGSPSSAELE-SGFNRQRKRKLS--------FRRRTDKDTEQPGEVSALGQ 983

  Fly   795 GTWRLECEPQSRARSGRLYSLQPKRRPRSRPDAT 828
            |..|:...|..|.:.|..:...|...| |.|:::
  Rat   984 GPARVGPGPSCRGQPGGPWGESPSSGP-SSPESS 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	60/241 (25%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	39/124 (31%)
		CAP_ED	604..717	CDD:237999	38/113 (34%)
		CLZ	720..791	CDD:293134	13/81 (16%)
Kcnh2	XP_006235929.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840