Protein Alignment CngA and Kcnh2

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_446401.1
• Gene: Kcnh2 / 117018
• RGDID: 621414
• Length: 1163
• Species: Rattus norvegicus
• Alignment Length: 943
• Identity: 215/943 - (22%)
• Similarity: 350/943 - (37%)
• Gaps: 226/943 - (23%)

  Fly    46 LVGPASSAPAQLQLPCGSHQATLGVAPPPLE----EISGGLFAPFAPTATITVEQAAT------- 99
            |.||.:...|..|:.    ||.||.....:|    ...|..|........:..|..|.
  Rat    69 LHGPRTQRRAAAQIA----QALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNF 129

  Fly   100 SIPMAVD---GEVHHLHY--PRRSW----------------------QRKYRQGIHRQPG--GGA 135
            .:.|..|   ...|..::  |..||                      :...|.|....||  |..
  Rat   130 EVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAV 194

  Fly   136 EQDED--------EEEDDDDVDEDDDDEFGASVCED-----NPEEAIARAD----HDTQQKQHYQ 183
            ..|.|        |....|:|...|:...|....|:     .|..|...|.    |.:.:.|...
  Rat   195 VVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASIPGPHPSPRAQSLN 259

  Fly   184 PNASDSSYVENGRKLIQEPSKRSKPSALRRT----LQALRQRLTKRNRPKPP------------- 231
            |:||.||.     .|.:..|:.|..|..|.:    ::|:|....    |.||
  Rat   260 PDASGSSC-----SLARTRSRESCASVRRASSADDIEAMRAGAL----PLPPRHASTGAMHPLRS 315

  Fly   232 -------DWFLEKFSNTTNTDKIG------KGCPAMEDAALSSEI--------------RGSSVL 269
                   |..|.::...:...:|.      ||.|.:.......||              :.:.||
  Rat   316 GLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVL 380

  Fly   270 CNRLSVDP--TLQS---------HYR-----WLAIVSLAVLYNIIFVVGRAVF----WEINKSAP 314
            .....|.|  .||:         ||.     |..::.|.|:|..:|....|.|    .|....||
  Rat   381 SLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAP 445

  Fly   315 AFWY------TLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSML 371
            ...|      .:|.|.|.::::|.|::....:::.. .:|....|:..|||  |||:| |:::.:
  Rat   446 DCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYF--KGWFLIDMVAAI 508

  Fly   372 PTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVL 436
            |.||.......|....|       ::..||||:.|:....||............:|...|    :
  Rat   509 PFDLLIFGSGSEELIGL-------LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL----I 562

  Fly   437 IHWNACMYFAISYEIGFSSDS---WVYNL----------NGTRNNTLQRQYIYSFYWSTLTLTTI 488
            .||.||:::||........||   |::||          :|....:::.:|:.:.|::..:||::
  Rat   563 AHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 627

  Fly   489 G-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVG 552
            | ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......:..:|..|::::.|.::.
  Rat   628 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIP 692

  Fly   553 HELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALV 617
            :.|..|:..:|.:.||.:..:|...||...|:.|:|:|.:.::...|:..:.|.....|.|.||.
  Rat   693 NPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 757

  Fly   618 LKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGE-VSVLEIAGNR 681
            :|.|.....|||.:...||:...:|.:.||.:.::..|  .|:|.||...:||| :::....|..
  Rat   758 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGD--VVVAILGKNDIFGEPLNLYARPGKS 820

  Fly   682 TGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFAD----- 741
            .|     :||:|.|.||..:.:.||.|.|..|||                       |:|
  Rat   821 NG-----DVRALTYCDLHKIHRDDLLEVLDMYPE-----------------------FSDHFWSS 857

  Fly   742 -----SQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAK-LEMNG-----GPG 795
                 :.|..:.|.|.....||. ...|.:..|.|:        .::|..| .|..|     |.|
  Rat   858 LEITFNLRDTNMIPGSPSSAELE-SGFNRQRKRKLS--------FRRRTDKDTEQPGEVSALGQG 913

  Fly   796 TWRLECEPQSRARSGRLYSLQPKRRPRSRPDAT 828
            ..|:...|..|.:.|..:...|...| |.|:::
  Rat   914 PARVGPGPSCRGQPGGPWGESPSSGP-SSPESS 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	70/277 (25%)
		CAP_ED	604..717	CDD:237999	38/113 (34%)
		CLZ	720..790	CDD:465160	12/80 (15%)
Kcnh2	NP_446401.1	PAS_9	38..130	CDD:463873	14/64 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..286		15/55 (27%)
		Ion_trans	411..670	CDD:459842	68/271 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472	626..631		1/4 (25%)
		CAP_ED	744..855	CDD:237999	40/140 (29%)
		cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060	744..844		34/106 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	873..992		19/83 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1043
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1163