DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and Hcn3

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_446137.1	Gene:	Hcn3 / 114245	RGDID:	620691	Length:	780	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	158/607 - (26%)
Similarity:	270/607 - (44%)	Gaps:	104/607 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 VDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEG 339
            :.|.....:.|..|:.|.::.|:|.:.....|::...|.|  |...:.|.|..:|||.:::...|
  Rat    85 IHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP--WIVFNVLSDTFFLLDLVLNFRTG 147

  Fly   340 F-LDQG---LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAY--IWWPPETCSSLYLPCPV--- 394
            . :::|   ||...|.|.|  |..|  |:| |::|.:|.|..:  :...|...:.:|.....
  Rat   148 IVVEEGAEILLAPRAIRTR--YLRT--WFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRI 208

  Fly   395 -----IVRLNRLLRINRL------WE-----WFDRTETATGYPNAFRICKVVLAILVLIHWNACM 443
                 |:.|.||||::||      ||     .:|......      ||..::..:|:|.||:.|:
  Rat   209 VRFTKILSLLRLLRLSRLIRYMHQWEEIFHMTYDLASAVV------RIFNLIGMMLLLCHWDGCL 267

  Fly   444 YFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG---ETPTPENDVEYLFVVA 505
            .|.:.....|.||.|| ::|...|::..|||.::.:.:...:..||   :.|....||  ...:.
  Rat   268 QFLVPMLQDFPSDCWV-SMNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDV--WLTML 329

  Fly   506 DFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQS 570
            ..:.|...:|..:|:..::|.:::.:|.::|.:...|:|||:|.::..:...|:..::.:.: |.
  Rat   330 SMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QG 393

  Fly   571 GALDEERVLAALPDKLKAEI------AIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGD 629
            ...|||.:|..|.:.|:.||      .:..||.      :|...:|..:.|::.||:.:||.|||
  Rat   394 KMFDEESILGELSEPLREEIINFTCRGLVAHMP------LFAHADPSFVTAVLTKLRFEVFQPGD 452

  Fly   630 YICRKGDVGKEMYIVKRGKLSVVG----DDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANV 690
            .:.|:|.||::||.::.|.|||:.    |..:|      .||.|||:.:|      |..||||:|
  Rat   453 LVVREGSVGRKMYFIQHGLLSVLARGARDTRLT------DGSYFGEICLL------TRGRRTASV 505

  Fly   691 RSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR----KDGLLDEQIFADSQRVHDSIEG 751
            |:..|..|:.|:.......|.::|..|..........||    |:.:|..:   .|:....|..|
  Rat   506 RADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRK---RSEPSPGSSSG 567

  Fly   752 GIEKLELSVENLNM-RLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRA-------R 808
            |:.:..|...:.:| |..|.||..|.::           ::|.|..|    ||...|       .
  Rat   568 GVMEQHLVQHDRDMARGIRGLAPGTGAR-----------LSGKPVLW----EPLVHAPLQAAAVT 617

  Fly   809 SGRLYSLQPKRRPRS-RPDATA 829
            |....:|..:|.|.. .||:.|
  Rat   618 SNVAIALTHQRGPLPLSPDSPA 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	63/248 (25%)
		Ion_trans_2	<477..527	CDD:285168	9/52 (17%)
		Crp	598..>722	CDD:223736	41/127 (32%)
		CAP_ED	604..717	CDD:237999	40/116 (34%)
		CLZ	720..791	CDD:293134	15/75 (20%)
Hcn3	NP_446137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		1/4 (25%)
		Ion_trans_N	48..90	CDD:285597	1/4 (25%)
		Ion_trans	110..357	CDD:278921	64/261 (25%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	353..780		88/324 (27%)
		Crp	421..>557	CDD:223736	47/156 (30%)
		CAP_ED	427..535	CDD:237999	41/119 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..569		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..780
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840