DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and Hcn2

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_446136.1	Gene:	Hcn2 / 114244	RGDID:	620689	Length:	863	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	168/719 - (23%)
Similarity:	305/719 - (42%)	Gaps:	133/719 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 DEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPSKRSK---------PS 209
            |..||:.....|......|....|......||.:..|:.|:.    .||..||:         |.
  Rat    12 DSPGATPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESA----DEPGPRSRLCSRDSSCTPG 72

  Fly   210 ALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGC------PA------MEDAALSSE 262
            |.:........|...:..|:.|          ....|:...|      ||      .|:|..:.|
  Rat    73 AAKGGANGECGRGEPQCSPEGP----------ARGPKVSFSCRGAASGPAAAEEAGSEEAGPAGE 127

  Fly   263 IRGSSVL-------------CNRLS------------------------VDPTLQSHYRWLAIVS 290
            .|||...             .|:.|                        :.|.....:.|...:.
  Rat   128 PRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTML 192

  Fly   291 LAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFL--DQGLLVRDAFRL 353
            |.::.|:|.:.....|::...:||  |...:.:.|..:|:|.:::...|.:  |...::.|..::
  Rat   193 LFMVGNLIIIPVGITFFKDETTAP--WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKI 255

  Fly   354 RRHYFHTKGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPV--------IVRLNRLLRINRL-- 407
            ::.|..|  |: :|.:|.:|.|..::.......|.:|.....        |:.|.||||::||
  Rat   256 KKKYLRT--WFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIR 318

  Fly   408 ----W-EWFDRT-ETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTR 466
                | |.|..| :.|:.   ..|||.::..:|:|.||:.|:.|.:.....|.||.|| ::|...
  Rat   319 YIHQWEEIFHMTYDLASA---VMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWV-SINNMV 379

  Fly   467 NNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNV 530
            |::....|.::.:.:...:..|| ....||:..:....:...:.|...:|..:|:..::|.:::.
  Rat   380 NHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDS 444

  Fly   531 ARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVH 595
            :|.::|.:...|:|||:|.::..:...::..::.:.: |....||:.:|..|...|:.||   |:
  Rat   445 SRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSILGELNGPLREEI---VN 505

  Fly   596 MDTLKQVR---IFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV--GDD 655
            .:..|.|.   :|.:.:|..:.|::.|||.:||.|||||.|:|.:||:||.::.|.:||:  |:.
  Rat   506 FNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNK 570

  Fly   656 GITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEAR--- 717
            .:    .|..||.|||:.:|      |..||||:||:..|..|:.|:..:..|.|.:||..|
  Rat   571 EM----KLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 625

  Fly   718 -STLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKI 781
             :....|..::.:|:.:|..::      .||...|.....|.::....::..|.:.:    ||::
  Rat   626 ETVAIDRLDRIGKKNSILLHKV------QHDLSSGVFNNQENAIIQEIVKYDREMVQ----QAEL 680

  Fly   782 KQRL 785
            .||:
  Rat   681 GQRV 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	56/239 (23%)
		Ion_trans_2	<477..527	CDD:285168	8/50 (16%)
		Crp	598..>722	CDD:223736	47/132 (36%)
		CAP_ED	604..717	CDD:237999	44/114 (39%)
		CLZ	720..791	CDD:293134	12/66 (18%)
Hcn2	NP_446136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		27/132 (20%)
		Involved in subunit assembly. /evidence=ECO:0000250	131..182		4/50 (8%)
		Ion_trans_N	140..182	CDD:285597	3/41 (7%)
		Ion_trans	202..447	CDD:278921	57/252 (23%)
		Crp	511..>646	CDD:223736	49/144 (34%)
		CAP_ED	517..625	CDD:237999	45/117 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840