DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngA and Hcn2

DIOPT Version :10

Sequence 1:NP_001188960.1 Gene:CngA / 36806 FlyBaseID:FBgn0261612 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_446136.1 Gene:Hcn2 / 114244 RGDID:620689 Length:863 Species:Rattus norvegicus


Alignment Length:719 Identity:168/719 - (23%)
Similarity:305/719 - (42%) Gaps:133/719 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 DEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPSKRSK---------PS 209
            |..||:.....|......|....|......||.:..|:.|:.    .||..||:         |.
  Rat    12 DSPGATPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESA----DEPGPRSRLCSRDSSCTPG 72

  Fly   210 ALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGC------PA------MEDAALSSE 262
            |.:........|...:..|:.|          ....|:...|      ||      .|:|..:.|
  Rat    73 AAKGGANGECGRGEPQCSPEGP----------ARGPKVSFSCRGAASGPAAAEEAGSEEAGPAGE 127

  Fly   263 IRGSSVL-------------CNRLS------------------------VDPTLQSHYRWLAIVS 290
            .|||...             .|:.|                        :.|.....:.|...:.
  Rat   128 PRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTML 192

  Fly   291 LAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFL--DQGLLVRDAFRL 353
            |.::.|:|.:.....|::...:||  |...:.:.|..:|:|.:::...|.:  |...::.|..::
  Rat   193 LFMVGNLIIIPVGITFFKDETTAP--WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKI 255

  Fly   354 RRHYFHTKGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPV--------IVRLNRLLRINRL-- 407
            ::.|..|  |: :|.:|.:|.|..::.......|.:|.....        |:.|.||||::||  
  Rat   256 KKKYLRT--WFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIR 318

  Fly   408 ----W-EWFDRT-ETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTR 466
                | |.|..| :.|:.   ..|||.::..:|:|.||:.|:.|.:.....|.||.|| ::|...
  Rat   319 YIHQWEEIFHMTYDLASA---VMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWV-SINNMV 379

  Fly   467 NNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNV 530
            |::....|.::.:.:...:..|| ....||:..:....:...:.|...:|..:|:..::|.:::.
  Rat   380 NHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDS 444

  Fly   531 ARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVH 595
            :|.::|.:...|:|||:|.::..:...::..::.:.: |....||:.:|..|...|:.||   |:
  Rat   445 SRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDSILGELNGPLREEI---VN 505

  Fly   596 MDTLKQVR---IFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV--GDD 655
            .:..|.|.   :|.:.:|..:.|::.|||.:||.|||||.|:|.:||:||.::.|.:||:  |:.
  Rat   506 FNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNK 570

  Fly   656 GITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEAR--- 717
            .:    .|..||.|||:.:|      |..||||:||:..|..|:.|:..:..|.|.:||..|   
  Rat   571 EM----KLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 625

  Fly   718 -STLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKI 781
             :....|..::.:|:.:|..::      .||...|.....|.::....::..|.:.:    ||::
  Rat   626 ETVAIDRLDRIGKKNSILLHKV------QHDLSSGVFNNQENAIIQEIVKYDREMVQ----QAEL 680

  Fly   782 KQRL 785
            .||:
  Rat   681 GQRV 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngANP_001188960.1 Ion_trans 282..529 CDD:459842 61/266 (23%)
CAP_ED 604..717 CDD:237999 44/114 (39%)
CLZ 720..790 CDD:465160 12/66 (18%)
Hcn2NP_446136.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..131 27/132 (20%)
Involved in subunit assembly. /evidence=ECO:0000250 131..182 4/50 (8%)
Ion_trans_N 140..182 CDD:400630 3/41 (7%)
PLN03192 175..>661 CDD:215625 131/513 (26%)
CAP_ED 517..625 CDD:237999 45/117 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..863
PRK07003 <769..>862 CDD:235906
Blue background indicates that the domain is not in the aligned region.

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