DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngA and Kcnh4

DIOPT Version :10

Sequence 1:NP_001188960.1 Gene:CngA / 36806 FlyBaseID:FBgn0261612 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_446082.2 Gene:Kcnh4 / 114032 RGDID:621415 Length:1016 Species:Rattus norvegicus


Alignment Length:678 Identity:173/678 - (25%)
Similarity:296/678 - (43%) Gaps:141/678 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   204 KRSKPSALRRTLQALR---QRLT-----------KRN----RPKP--PDWFLEKFSNTTNTDKIG 248
            :|...|.||.|.:..|   .|||           |.|    .|||  |::            |: 
  Rat   158 RRGASSRLRSTRRQNRTVLHRLTGHFGRRDQGSVKANSNVFEPKPSVPEY------------KV- 209

  Fly   249 KGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSA 313
                        :.:.||..|....|:...:     |..::.||..|..:.|.....|...:.:.
  Rat   210 ------------ASVGGSRCLLLHYSIPKAV-----WDGLILLATFYVAVTVPYNVCFAGDDDTP 257

  Fly   314 PAFWYTL--DYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHTKGW-YLDVLSMLPTD 374
            ....:||  |...:.:::||.:::....::.| |.:|.....:..||..|  | ::|:::.||.|
  Rat   258 ITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVVSAPRSIGLHYLAT--WFFVDLIAALPFD 320

  Fly   375 LAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAIL----- 434
            |.|::  ..|.:||.    .:::..||||:.||.:..:|....:.         |||.:|     
  Rat   321 LLYVF--NITVTSLV----HLLKTVRLLRLLRLLQKLERYSQCSA---------VVLTLLMSVFA 370

  Fly   435 VLIHWNACMYFAIS-----------YEIGFSSDSWVYNL---------NGTRNNTLQRQ-YIYSF 478
            :|.||.||:::.|.           ::||     |::.|         ||:.....:|. ||.:.
  Rat   371 LLAHWMACVWYVIGRREMEANDPLLWDIG-----WLHELGKRLEEPYVNGSAGGPSRRSAYIAAL 430

  Fly   479 YWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGV 542
            |::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.::|..|...|..:.:||..:
  Rat   431 YFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495

  Fly   543 KQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHD 607
            |.::...|:...|:.|::.:|..||:.:..:|...:|...||:|:|:||:.::.:.| |:.:|..
  Rat   496 KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGA 559

  Fly   608 TEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEV 672
            ...|.|.||.|.:|....:||:::.|:||..:..|.|..|.|.|:.|:  ||||.||.|.:.| .
  Rat   560 ASRGCLRALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSLEVLRDN--TVLAILGKGDLIG-A 621

  Fly   673 SVLEI-----AGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDG 732
            .:.|:     ||.....:.:|:|::|.|..|..|:.|.|.|.|..|||..:..         :.|
  Rat   622 DIPELGQEPGAGAGCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYVAAF---------RAG 677

  Fly   733 LLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEMNGGPGTW 797
            |..:..|        ::..|.|...|...:.:.||::..:: |...:..|...:..|..||    
  Rat   678 LPRDLTF--------NLRQGSENNGLGRFSRSPRLSQARSD-TLGSSSDKTLPSITETEGG---- 729

  Fly   798 RLECEPQSRARSGR---LYSLQPKRRPR 822
               .||.:.::..|   |.:|.| .|||
  Rat   730 ---MEPGAGSKPRRPLLLPNLSP-ARPR 753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngANP_001188960.1 Ion_trans 282..529 CDD:459842 68/277 (25%)
CAP_ED 604..717 CDD:237999 42/117 (36%)
CLZ 720..790 CDD:465160 10/69 (14%)
Kcnh4NP_446082.2 PRK13559 41..>134 CDD:237427
PLN03192 177..>620 CDD:215625 128/497 (26%)
Selectivity filter. /evidence=ECO:0000250 439..444 1/4 (25%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 556..620 25/65 (38%)
cNMP_binding 578..665 CDD:459637 31/89 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 689..748 14/66 (21%)
PHA03247 <732..1007 CDD:223021 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..869
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..1016
Blue background indicates that the domain is not in the aligned region.

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