Protein Alignment CngA and kcnh1b

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_009294796.1
• Gene: kcnh1b / 101154640
• ZFINID: ZDB-GENE-121128-4
• Length: 965
• Species: Danio rerio
• Alignment Length: 800
• Identity: 196/800 - (24%)
• Similarity: 314/800 - (39%)
• Gaps: 204/800 - (25%)

  Fly   201 EPSKRSKPSALRRT-----LQALRQRLTKRNRPKPPDWFLEKFSNTTN-TDKI------------ 247
            |.|.:.....||:|     :.:....:.|:||  .|.||..|.:...| .||:
Zfish    80 ELSDKETSEKLRQTFENYEMNSFELLMYKKNR--MPVWFFVKIAPIRNEQDKVVLFLCTFSDITA 142

  Fly   248 -----------GKGCPAMEDAALSSE-----------IRGSSVL-CNRLS--------------- 274
                       |.|..|....||:|.           .||.:|| .:||:
Zfish   143 FKQPIEDDSSKGWGKFARLTRALTSSRGVLQQLAPTVQRGENVLKHSRLAEVLQLGSDILPQYKQ 207

  Fly   275 ----VDPTLQSHY-------RWLAIV-----SLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYL 323
                ..|.:..||       .|:.::     ::.|.||:.|.         .|.....|..:|.:
Zfish   208 EAPKTPPHIILHYCTFKTTWDWVILILTFYTAIMVPYNVSFK---------TKQNNVTWLVVDSI 263

  Fly   324 CDFIYLLDTLVHMHEGFL-DQGLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIWW-PPETC 385
            .|.|:|:|.:::.|..|: ..|.::.|...:|.:|  .|.|: :|:||.||.|:...:. ..|..
Zfish   264 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY--VKTWFVIDLLSCLPYDVINAFENVDEGI 326

  Fly   386 SSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLI-----HWNACMYF 445
            |||:....|:    ||||:.|:....|         :.......||.:||.:     ||.||:::
Zfish   327 SSLFSSLKVV----RLLRLGRVARKLD---------HYIEYGAAVLVLLVCVFGLAAHWLACIWY 378

  Fly   446 AI-SYEI------GFSSDSWVY------------NLNGT----RNNTLQRQYIYSFYWSTLTLTT 487
            :| .||:      ...:|||:|            |.:|:    ...:....||.|.|::..:||:
Zfish   379 SIGDYEVIDQDANMVRTDSWLYLLGEAVGQPYHFNASGSGKWEGGPSKDSVYITSLYFTMTSLTS 443

  Fly   488 IG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRV 551
            || ....|..|.|.:|.||..:.|.|::|||.||:.::...|......:...::.|:.::...:|
Zfish   444 IGFGNIAPTTDGEKIFAVAMMMIGSLLYATIFGNVTNIFQQMYANTNRYHEMLNSVRDFLKLYQV 508

  Fly   552 GHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEAL 616
            ...|..||:.:...|||.|..:|.::||...|..::|:|.:.::....|:...|.....|.|.||
Zfish   509 PKGLSERVMDYIVSTWSMSRGIDTDKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRAL 573

  Fly   617 VLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNR 681
            .::.:....:|||.|...|:....:..|..|.|.|:.||  .|:|.||.|.|||:|...|:
Zfish   574 AMEFQTIHSAPGDLIYHAGESVDSLCFVVSGSLEVIQDD--EVVAILGKGDVFGDVFWKEV---- 632

  Fly   682 TGN--RRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQL---LRKDGLLDEQIFAD 741
              |  :..||||:|.|.||. :.|||..:.:.::..|.:....|...|   |||     ..:|..
Zfish   633 --NLAQSCANVRALTYCDLH-IIKRDALQKVLEFYTAFAGHFSRNLVLTYNLRK-----RIVFRK 689

  Fly   742 SQRVHDSIEGGIEKLELSVENL--------------NMRLARLLA------EYTASQAKIKQRLA 786
            ...|....|..:.:...:..||              ..|.|||.|      |....:.|.:|.:.
Zfish   690 ISDVKREEEEMLRRKNEAPLNLPPDHPVRRLFQRFRQQREARLAAERANQVEQDVEKGKSEQTVV 754

  Fly   787 K--------LEMNGGPGT----------WRLECE--------PQSRARSGRLYSLQPKRRPRSR- 824
            |        :.:...|.|          .:..|.        |.:..:|..    .||.:..||
Zfish   755 KEITSPTSIITVTESPATLNTLSPTTPSTKTLCRAKLNTPLAPNTAQKSAE----APKSKGWSRF 815

  Fly   825 PDATAKS----SDAAKQNTL 840
            .:|||||    |..:|..::
Zfish   816 KEATAKSDLSLSSVSKAESM 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	77/290 (27%)
		CAP_ED	604..717	CDD:237999	38/114 (33%)
		CLZ	720..790	CDD:465160	19/100 (19%)
kcnh1b	XP_009294796.1	PAS_9	48..142	CDD:463873	15/63 (24%)
		PLN03192	227..>627	CDD:215625	116/425 (27%)
		PRK11753	588..>692	CDD:236969	37/117 (32%)