Protein Alignment CngA and cnga3

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_031752880.1
• Gene: cnga3 / 100494840
• XenbaseID: XB-GENE-948568
• Length: 737
• Species: Xenopus tropicalis
• Alignment Length: 752
• Identity: 342/752 - (45%)
• Similarity: 455/752 - (60%)
• Gaps: 123/752 - (16%)

  Fly   138 DEDEEEDDDDVDEDDDDEFGASVCEDNPEE------------------------AIARAD----- 173
            ||:.|..::....:.      |:|||...|                        .:||..
 Frog    23 DEEIERIENGTSRNH------SLCEDTSSELQRVIALEPRGLAESRRSSFTGRGGMARLTRLLIT 81

  Fly   174 -------HDTQQKQHYQPNASDSSYVE--NGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPK 229
                   |.||:.|  :|:    |::|  .|..|.:..|:.|.    .::||..::||.:.|
 Frog    82 LRNWAMRHLTQEDQ--RPD----SFLERFRGPDLKEVSSRESN----IQSLQENQERLERVN--- 133

  Fly   230 PPDWFLEKF----SNTTNTDKIGKGCPAME--------------------------DAALSSEIR 264
             ..|.|..|    ||.....|..|. ||.|                          |.....|.:
 Frog   134 -SHWVLASFNVNNSNNAEDTKNDKK-PANENKDQKPEEKKEEKKDDKKDDKKDDKKDDKKKEEEK 196

  Fly   265 GSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYL 329
            ...:..    :||:...:||||:|:|:.||||..|:|.||.|.|:.:::...|..|||..|.||:
 Frog   197 KKEIFV----IDPSSNLYYRWLSIISVPVLYNWCFLVCRACFDELQRNSIILWLVLDYTADVIYI 257

  Fly   330 LDTLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPV 394
            .||||....|||:|||||:||.:|:.:|..|:.:.||:||:|||||.|:        .:.|..|.
 Frog   258 TDTLVRFRTGFLEQGLLVKDAKKLKENYSKTRQFKLDLLSLLPTDLTYL--------KIGLNYPE 314

  Fly   395 IVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWV 459
            : |.|||||..|::|:||||||.|.|||.|||..:||.||::||||||:|||||..|||.:|:||
 Frog   315 L-RFNRLLRFGRMFEFFDRTETRTNYPNIFRIGNLVLYILIIIHWNACIYFAISKAIGFGTDTWV 378

  Fly   460 Y-NLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGS 523
            | |::......|.|:||||.||||||||||||||.|..|:|:||||.|||.|||||||||||:||
 Frog   379 YPNISHPEYGRLARKYIYSLYWSTLTLTTIGETPPPVKDIEFLFVVFDFLIGVLIFATIVGNVGS 443

  Fly   524 MISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKA 588
            ||||||.::.|||:::|.:||||.||:|..:||||||:||.|.|:....:||:.||.:|||||||
 Frog   444 MISNMNASKAEFQSKIDSIKQYMQFRKVTKDLEARVIKWFDYLWTNKKTMDEKEVLKSLPDKLKA 508

  Fly   589 EIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVG 653
            ||||.||:||||:||||.|.|.|||..|||||:.||||||||||||||:|:||||:|.|||:||.
 Frog   509 EIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGREMYIIKEGKLAVVA 573

  Fly   654 DDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARS 718
            |||:|....|..||.|||:|:|.|.|:::|||||||:||:||||||||:|.||.|.|::||:|::
 Frog   574 DDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKT 638

  Fly   719 TLTQRGCQLLRKDGLLDEQIF---ADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAK 780
            .|.::|.|:|.||||:||:..   ||.:    .:|..:||:|.::::|..|.|||||:|.::|.|
 Frog   639 VLEEKGRQILMKDGLIDEEAAKAGADPK----DVEEKVEKMETAMDSLQTRFARLLADYNSTQLK 699

  Fly   781 IKQRLAKLE-----------MNGGPGTWRLECEPQSR 806
            :|||:.|||           ..||...  .|.:||.:
 Frog   700 LKQRVTKLESQVKKCYGDNASEGGDSA--AEGDPQRK 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	143/247 (58%)
		CAP_ED	604..717	CDD:237999	75/112 (67%)
		CLZ	720..790	CDD:465160	32/83 (39%)
cnga3	XP_031752880.1	Ion_trans	210..452	CDD:459842	145/250 (58%)
		CAP_ED	524..635	CDD:237999	74/110 (67%)
		CLZ	640..709	CDD:465160	31/72 (43%)