Protein Alignment CngA and kcnh2

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_031759588.1
• Gene: kcnh2 / 100491983
• XenbaseID: XB-GENE-983104
• Length: 1194
• Species: Xenopus tropicalis
• Alignment Length: 760
• Identity: 177/760 - (23%)
• Similarity: 304/760 - (40%)
• Gaps: 149/760 - (19%)

  Fly   137 QDEDEE------EDDDDVDEDDDDEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENG 195
            |.||::      |.....||           |.|.|.|:..:.|..:...:...:.|:.|...:
 Frog   221 QSEDQQALIGSKEPKAPPDE-----------EGNKESAVQSSPHTDKDLLNLDMSFSNCSLSRS- 273

  Fly   196 RKLIQEPSKRSKPS--ALRRT-----LQALRQRLTK-RNR---------------PKPPDWFLEK 237
                     ||:.|  ::||.     ::|::..|.| |||               ....|..|.:
 Frog   274 ---------RSRESFYSIRRASSVDEIEAMKVDLEKFRNRNSSTGAMNNIRANLLNSTSDSDLMR 329

  Fly   238 FSNTTNTDKIG------KGCPAMEDAALSSEIRGSSVLCNR-------------LSVD------- 276
            :...:...:|.      ||...:...:...||...|.|.:|             |..|
 Frog   330 YRTISKIPQITLNFVDFKGDSFLTSPSNEKEIIAPSKLKDRTHNVTEKVTQVLSLGADVLPEYKL 394

  Fly   277 --PTLQS----HYR-----WLAIVSLAVLYNIIFVVGRAVF--------------WEINKSAPAF 316
              |.:..    ||.     |..::.|.|:|..||....|.|              :..|..:
 Frog   395 QAPRIHKWTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLGDQEEAENEQCGYSCNPLS--- 456

  Fly   317 WYTLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAY-- 377
              .:|.:.|.::::|.|::....:::.. .:|....::..|||  |||:| |:::.:|.||..
 Frog   457 --VVDLIVDIMFIIDILINFRTTYVNTNEEVVSHPGKIAIHYF--KGWFLIDMVAAIPFDLLIFG 517

  Fly   378 -----IWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLI 437
                 |..|.|..:........:::..||||:.|:....||............:|...|    :.
 Frog   518 SGSEEIKRPDEGANKETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL----IA 578

  Fly   438 HWNACMYFAIS----YEIGFSSDSWVYNL-----------NGTRNNTLQRQYIYSFYWSTLTLTT 487
            ||.||:::||.    |:..:....|:|:|           |.....::..:|:.:.|::..:||:
 Frog   579 HWLACIWYAIGNMEHYDQEYRPIGWLYSLGIQIMKPYNSTNAKSGPSINDKYVTALYFTFSSLTS 643

  Fly   488 IG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRV 551
            :| ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......:..:|..|::::.|.::
 Frog   644 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQI 708

  Fly   552 GHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEAL 616
            .:.|..|:..:|.:.||.:..:|...||...|:.|:|:|.:.::...|:..:.|.....|.|.||
 Frog   709 PNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQNCKPFKGATKGCLRAL 773

  Fly   617 VLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNR 681
            .:|.|.....|||.:...|||...:|.:.||.:.::..|  .|:|.||...:|||...|..   |
 Frog   774 AMKFKTTHAPPGDTLVHAGDVLTAVYFLSRGSIEILRGD--VVVAILGKNDIFGEPINLYA---R 833

  Fly   682 TGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVH 746
            .| :..|:||:|.|.||..:.:.||.|.|..|||.......   .|.....|.|..:...|....
 Frog   834 PG-KSNADVRALTYCDLHKIHREDLLEVLDMYPEFSDYFWS---SLEITFNLRDTNMIPGSPSSD 894

  Fly   747 DSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEMN 791
            || :.|..:|..  ..|:.|.........|.:||..||:.:|..|
 Frog   895 DS-DSGFNRLRR--RKLSFRRRTDKDAENAGEAKRSQRMGRLSRN 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	66/290 (23%)
		CAP_ED	604..717	CDD:237999	41/112 (37%)
		CLZ	720..790	CDD:465160	16/69 (23%)
kcnh2	XP_031759588.1	PAS_9	38..135	CDD:463873
		PLN03192	401..>866	CDD:215625	121/481 (25%)