Protein Alignment CngA and kcnh4

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_002942364.2
• Gene: kcnh4 / 100488431
• XenbaseID: XB-GENE-1014062
• Length: 1074
• Species: Xenopus tropicalis
• Alignment Length: 789
• Identity: 183/789 - (23%)
• Similarity: 323/789 - (40%)
• Gaps: 175/789 - (22%)

  Fly   134 GAEQDEDEEEDDDDVDEDDDDEFGASVC--------------------------------EDNPE 166
            |.|..|:..:|.:.| .|:..|:.|.||                                :|..|
 Frog    72 GVETSENVIQDIERV-LDEKQEYQAEVCLYKKDANLFWCQLDIVPIKNEKGEVVLFLFSFKDTTE 135

  Fly   167 EAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPP 231
            ..:.....|.::::|....:..|.:             ||.....|..:..:..::..||:..
 Frog   136 IRMRMQYSDKKEEKHKNRRSGSSHF-------------RSSRRQSRTMMCQMSGQVAGRNKSD-- 185

  Fly   232 DWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAI-----VSL 291
               |:..||..:..      |::.:..::|..:...:|.: .|:...|   :.||.:     |::
 Frog   186 ---LKLNSNLLDNK------PSLPEYKVASAEKPRFILLH-YSIFKAL---WDWLILLATFYVAV 237

  Fly   292 AVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLD-QGLLVRDAFRLRR 355
            .|.||:.| .|.    :.:.||.......|...:.::::|.:::....::. .|.:|.:...:..
 Frog   238 TVPYNVCF-TGH----DDSVSAARSTIVSDIAVEMLFIIDIILNFRTTYVSHSGQVVYETRSICI 297

  Fly   356 HYFHTKGW-YLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATG 419
            ||..|  | ::|:::.||.||.|.:  ..|.:||.    .:::..||||:.||.:..||..
 Frog   298 HYLAT--WFFVDLIAALPFDLLYAF--NVTVTSLV----HLLKTIRLLRLLRLLQKLDRYS---- 350

  Fly   420 YPNAFRICKVVLAIL-----VLIHWNACMYFAISYEIGFSSD------SWVYNLNGTR------N 467
                 :...:||.:|     :|.||.||:::.|..:...|:|      .|::.| |.|      |
 Frog   351 -----QYSAMVLTLLMSMFALLAHWMACVWYVIGRKEMESNDPVTWDIGWLHEL-GKRLEAPYIN 409

  Fly   468 N-----TLQRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMIS 526
            |     :::..||.|.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.::|.
 Frog   410 NSIGGPSIRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQ 474

  Fly   527 NMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIA 591
            .|...|..:..|:..:|.::....:..:|:.|.:.:|..|||.:..:|...:|...||:|:|:||
 Frog   475 RMYSRRSLYHTRVKDLKDFIRVHCLPQQLKQRTLEYFQTTWSVNNGIDANELLKDFPDELRADIA 539

  Fly   592 IQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDG 656
            :.::.|.| |:.:|.....|.|.||.|.:|....:||:|:.|:||..:..|.|..|.|.|:.|:
 Frog   540 MHLNKDIL-QLSVFETASRGCLRALSLHIKTSFCAPGEYLLRQGDALQANYFVCSGSLEVLKDN- 602

  Fly   657 ITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPE------ 715
             .|||.||.|.:.|    .:::......:..|:|::|.|.||..|:.|.|.|.|..|||
 Frog   603 -MVLAILGKGDLIG----ADLSNKDQVIKTNADVKALTYCDLQYLSLRGLLEVLELYPEYCNKFR 662

  Fly   716 ----------ARSTLTQRGCQLLRKDGLLDE--------------QIFADSQRVHDSIE---GGI 753
                      .|......||....:...|.:              .|..|:....|...   ..:
 Frog   663 ADIHHDLTFNLREGSETNGCYRFSRSPRLSQPRPESGATPEKKLASILEDNDETDDYFRHSPASM 727

  Fly   754 EKLELSVENLNMRLAR-----LLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRARSGRLY 813
            .:.:|.:.|||..:.|     ||.:      :::|..|          :|..|....|...||..
 Frog   728 TRRKLMLPNLNSPIRRGSLSSLLGD------ELRQFHA----------FRRNCRSPGRTNHGRSP 776

  Fly   814 SLQPKRRPR 822
            |.|.::..|
 Frog   777 SPQCRKAER 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	70/276 (25%)
		CAP_ED	604..717	CDD:237999	40/128 (31%)
		CLZ	720..790	CDD:465160	15/91 (16%)
kcnh4	XP_002942364.2	PAS_9	40..135	CDD:463873	11/63 (17%)
		PLN03192	224..>615	CDD:215625	116/416 (28%)
		PRK11753	578..>656	CDD:236969	28/83 (34%)