Protein Alignment CngA and kcnh5b

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_002664253.1
• Gene: kcnh5b / 100331767
• ZFINID: ZDB-GENE-090319-1
• Length: 1005
• Species: Danio rerio
• Alignment Length: 719
• Identity: 174/719 - (24%)
• Similarity: 296/719 - (41%)
• Gaps: 157/719 - (21%)

  Fly   194 NGRKLIQE--PSKRS-----KPSALRRTLQALRQRLT--KRNRPKPPDWFLEKFSNTTNTDKIGK 249
            |.:..||:  |..|:     |||.|...||.....|.  |:..||.|...:..:
Zfish   158 NSKSTIQQITPVSRTDVTSHKPSRLAEVLQLGSDILPQYKQEAPKTPPHIILHY----------- 211

  Fly   250 GCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIV-----SLAVLYNIIFVVGRAVFWEI 309
                                |       |.::.:.|:.::     ::.|.||:.|.
Zfish   212 --------------------C-------TFKTTWDWVILILTFYTAIMVPYNVSFK--------- 240

  Fly   310 NKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHTKGWY-LDVLSMLP 372
            .|.....|..||.:.|.|:|:|.:::.|..|:.. |.::.|...:|.:|..|  |: :|:||.||
Zfish   241 TKQNNVTWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPNLIRMNYLKT--WFVIDLLSCLP 303

  Fly   373 TDLAYIWW-PPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVL 436
            .|:...:. ..|..|||:....|:    ||||:.|:....|         :.......||.:||.
Zfish   304 YDIINAFENVDEGISSLFSSLKVV----RLLRLGRVARKLD---------HYLEYGAAVLVLLVC 355

  Fly   437 I-----HWNACMYFAI-SYEI------GFSSDSWV------------YNLNGT-------RNNTL 470
            :     ||.||::::| .||:      ...:|||:            ||.:||       ..::|
Zfish   356 VFGLVAHWLACIWYSIGDYEVIDEQTNTIKTDSWLFQLATSIGSPYRYNASGTGQWEGGPGKDSL 420

  Fly   471 QRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVE 534
               ||.|.|::..:||||| ....|..|.|.:|.||..:.|.|::|||.||:.::...|......
Zfish   421 ---YITSLYFTMTSLTTIGFGNIAPTTDGEKIFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR 482

  Fly   535 FQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTL 599
            :...::.|:.::...:|...|..||:.:...|||.|..:|.|:||:..|..::|:|.:.::....
Zfish   483 YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVF 547

  Fly   600 KQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLG 664
            .:...|.....|.|.:|.::.::...:|||.|...|:....:..|..|.|.|:.||  .|:|.||
Zfish   548 NEHPAFRLASDGCLRSLAVEFQMIHSAPGDLIFHAGESVDLLCFVVSGSLEVIQDD--EVIAILG 610

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQR---GCQ 726
            .|.|||:|...|    .|.....||||:|.|.||..:.:..|.:.|..|....::.::.   .|.
Zfish   611 KGDVFGDVFWKE----TTLAHSCANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLFLTCN 671

  Fly   727 LLRK-------DGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQR 784
            |.::       |...:|:   :.||..:.:     .|.:.|::    ..|.|.:....|.:::.:
Zfish   672 LRKRFVFRKIIDVKKEEE---ERQRSKNEV-----PLTIPVDH----PVRKLFQKFKQQKELRNQ 724

  Fly   785 LAKLEMNGGPGTWRLE-----CEPQSRARSGRLYSLQ----------PKRRPRSRPDATAKSSDA 834
            .|..:::.......|:     .:|.:......|:::|          .:..|.....|..|..|:
Zfish   725 GASAQLDLEKNQHHLQQPARMSKPHTSLMQNSLHAVQNGSTSSVVTISQITPIQNCLAYPKPGDS 789

  Fly   835 AKQN 838
            .|||
Zfish   790 IKQN 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	79/286 (28%)
		CAP_ED	604..717	CDD:237999	37/112 (33%)
		CLZ	720..790	CDD:465160	12/79 (15%)
kcnh5b	XP_002664253.1	PAS_9	39..132	CDD:463873
		PLN03192	218..>618	CDD:215625	119/428 (28%)