DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CngA and HCN4

DIOPT Version :9

Sequence 1:NP_001188960.1 Gene:CngA / 36806 FlyBaseID:FBgn0261612 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_005468.1 Gene:HCN4 / 10021 HGNCID:16882 Length:1203 Species:Homo sapiens


Alignment Length:731 Identity:171/731 - (23%)
Similarity:305/731 - (41%) Gaps:153/731 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 EEISGGLFAPF------------APTATITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIH 128
            ||.:||...|.            :|:|.....::.:|...|.|.|     .|.|...:....|..
Human    34 EEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSE-----GPARGAGKSSTNGDC 93

  Fly   129 RQ----------PGGGAE-----------QDEDEE-----EDDDDVDED--------DDDEFGAS 159
            |:          .|||:.           .|..||     |.|....||        :.:..|||
Human    94 RRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGAS 158

  Fly   160 V--------CEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGR----KLIQEPSKR-SKPSAL 211
            .        .:..|:.|.|..:         ||:...:..||.|.    :::.|...| .:...:
Human   159 AQPAASPPPPQQPPQPASASCE---------QPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFM 214

  Fly   212 RRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVD 276
            :|...|:.|       |....:.|..|.:....::        |...:.|  .|..:      :.
Human   215 QRQFGAMLQ-------PGVNKFSLRMFGSQKAVER--------EQERVKS--AGFWI------IH 256

  Fly   277 PTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFL 341
            |.....:.|...:.|.::.|:|.:.....|::...:.|  |...:.:.|..:|:|.:::...|.:
Human   257 PYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP--WIVFNVVSDTFFLIDLVLNFRTGIV 319

  Fly   342 --DQGLLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPV--------I 395
              |...::.|..|::..|.  |.|:: |.:|.:|.|..::.......|.:|.....        |
Human   320 VEDNTEIILDPQRIKMKYL--KSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKI 382

  Fly   396 VRLNRLLRINRL------WE-----WFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISY 449
            :.|.||||::||      ||     .:|......      ||..::..:|:|.||:.|:.|.:..
Human   383 LSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV------RIVNLIGMMLLLCHWDGCLQFLVPM 441

  Fly   450 EIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG---ETPTPENDVEYLFVVADFLAGV 511
            ...|..|.|| ::|...||:..:||.|:.:.:...:..||   :.|...:||  ...:...:.|.
Human   442 LQDFPDDCWV-SINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDV--WLTMLSMIVGA 503

  Fly   512 LIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEE 576
            ..:|..:|:..::|.:::.:|.::|.:...|:|||:|.::..:...|:..::.:.: |....|||
Human   504 TCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEE 567

  Fly   577 RVLAALPDKLKAEIAIQVHMDTLKQVR---IFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVG 638
            .:|..|.:.|:.||   ::.:..|.|.   :|.:.:|..:.:::.||:.:||.|||||.|:|.:|
Human   568 SILGELSEPLREEI---INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIG 629

  Fly   639 KEMYIVKRGKLSVV--GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCL 701
            |:||.::.|.:||:  |:..    ..|..||.|||:.:|      |..||||:||:..|..|:.|
Human   630 KKMYFIQHGVVSVLTKGNKE----TKLADGSYFGEICLL------TRGRRTASVRADTYCRLYSL 684

  Fly   702 AKRDLWETLSDYPEAR 717
            :..:..|.|.:||..|
Human   685 SVDNFNEVLEEYPMMR 700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngANP_001188960.1 Ion_trans 309..529 CDD:278921 56/244 (23%)
Ion_trans_2 <477..527 CDD:285168 9/52 (17%)
Crp 598..>722 CDD:223736 45/125 (36%)
CAP_ED 604..717 CDD:237999 42/114 (37%)
CLZ 720..791 CDD:293134
HCN4NP_005468.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..182 31/161 (19%)
Involved in subunit assembly. /evidence=ECO:0000250 209..260 10/73 (14%)
Ion_trans_N 218..260 CDD:285597 9/64 (14%)
Ion_trans 280..525 CDD:278921 57/257 (22%)
Crp 589..>724 CDD:223736 44/122 (36%)
CAP_ED 595..703 CDD:237999 43/116 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..856
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..1203
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145006
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.