DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and kcnh4a

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001309362.1	Gene:	kcnh4a / 100148126	ZFINID:	ZDB-GENE-131125-34	Length:	1151	Species:	Danio rerio

Alignment Length:	635	Identity:	167/635 - (26%)
Similarity:	268/635 - (42%)	Gaps:	151/635 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 QEPSKRSKPSALRRTLQALRQRLTK--------------------RNRPKPPDWFLEKFSNTTNT 244
            ||.|:| ....:.:||:..|:..|:                    :|.......||..|.|.  |
Zfish    73 QETSER-VTQQVEKTLEGQREFQTEVCYYRKNGTTFWCLLDIVPIKNEKGEVVLFLLSFKNI--T 134

  Fly   245 DKIGK---GCPAMEDAALSSEI----------RGSSVL----C-----------NRLSVDPTLQS 281
            |..||   |....||.....::          ||.:||    |           |.:...|||..
Zfish   135 DSYGKSHLGSSTEEDRRHGRKVGRTHLSQARERGRNVLYHLTCQFTNRSKRKLPNNVFSQPTLPE 199

  Fly   282 --------------HYR-------WLAI-----VSLAVLYNIIFVVGRAVFWEINKSAP------ 314
                          ||.       ||.:     |::.|.||:.|            |.|
Zfish   200 YKVASVQKSRFILLHYSVCKAMWDWLILLATFYVAVTVPYNVCF------------STPDDSQLD 252

  Fly   315 --------AFWYTLDYLCDFIYLLDTLVHMHEGFL-DQGLLVRDAFRLRRHYFHTKGWY-LDVLS 369
                    ......|...:.:::||.:::....:: ..|.:|.|...:..||..|  |: ||:::
Zfish   253 SPDCDSSSRTTIVSDIAVEMLFILDIILNFRTTYVGPAGQVVYDTRSICLHYCTT--WFILDLIA 315

  Fly   370 MLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAIL 434
            .||.||.|::....| |.::|     ::..||||:.||.:..|      ||.   :...|||.:|
Zfish   316 ALPFDLLYLFNISVT-SLVHL-----LKTVRLLRLLRLLQKLD------GYS---QYSAVVLTLL 365

  Fly   435 -----VLIHWNACMYFAISYEIGFSSD------SWVYNL---------NGTRNN-TLQRQYIYSF 478
                 :|.||.||:::.|..:...|:|      .|:..|         |||... :|:..||.|.
Zfish   366 MSVFALLAHWLACVWYVIGRQELASNDPLTWDIGWLQELGKRLETPYTNGTVGGPSLRSAYIASL 430

  Fly   479 YWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGV 542
            |::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.::|..|...|..:..||..:
Zfish   431 YFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRMKDL 495

  Fly   543 KQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHD 607
            |.::...|:..:|:.|::.:|..|||.:..::...:|...||:|:|:||:.::.|.| |:.:|..
Zfish   496 KDFIRVHRLPQQLKQRMLEYFQTTWSVNNGINANELLHDFPDELRADIAMHLNKDIL-QLPLFSS 559

  Fly   608 TEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEV 672
            ...|.|.:|.|.:|....:||:|:.|.||.....:.|..|.|.|: .||: |||.||.|.:.|
Zfish   560 ASRGCLRSLSLHIKTSFCAPGEYLIRHGDALHAQHFVCSGSLEVL-KDGM-VLAILGKGDLVG-- 620

  Fly   673 SVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQ 722
              .::.|.....:..|:|::|.|.||..::.|.|.|.|..|||..|...:
Zfish   621 --ADLPGKDQVIKANADVKALTYCDLQYISVRALQEVLELYPEYGSRFNE 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	67/257 (26%)
		Ion_trans_2	<477..527	CDD:285168	16/50 (32%)
		Crp	598..>722	CDD:223736	42/123 (34%)
		CAP_ED	604..717	CDD:237999	39/112 (35%)
		CLZ	720..791	CDD:293134	0/3 (0%)
kcnh4a	NP_001309362.1	PAS	42..133	CDD:238075	12/60 (20%)
		PAS_3	42..127	CDD:285623	9/54 (17%)
		Ion_trans	267..486	CDD:278921	66/235 (28%)
		Ion_trans_2	<426..480	CDD:285168	18/53 (34%)
		Crp	553..745	CDD:223736	41/122 (34%)
		CAP_ED	556..666	CDD:237999	40/115 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840