DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and tdrd15

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001182210.1	Gene:	tdrd15 / 799498	ZFINID:	ZDB-GENE-041014-303	Length:	1883	Species:	Danio rerio

Alignment Length:	871	Identity:	167/871 - (19%)
Similarity:	287/871 - (32%)	Gaps:	249/871 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HADLLYRSLIPLHDHLVASLSEVNAHVMKLNVQLHINRQSVRLGDYEYYEKSIDNPYSSIRSGLQ 108
            ||.|.|..||       ..:.|:|:.::|..:..|::..:..|    ..|..||.|.......:.
Zfish   163 HARLPYHILI-------LEVPEINSDMIKKRLGRHVDTSTFLL----LVEMLIDEPIPQSNESVP 216

  Fly   109 --AIEKP-GCAEAICQSSKPAFVECLPSS-----TSEEVPVVAVQEASSTNQLDAISVVNENLSE 165
              .|||. |....:..||...|.|.|..:     ..:||.||.....:.......:|.:.::|.|
Zfish   217 DLLIEKQIGQEYCLKSSSLLGFEEILSLNGPKLKVGQEVEVVVAAAVNPGLFYCRLSSMGKDLQE 281

  Fly   166 ERDATPQPLAVSKNMEETMPSNPFHEQL--------------EGSLEEIPVGSKIVV-------- 208
            ..|    .||::........:|...|.|              .|.:|.:|:.|::.|
Zfish   282 MSD----KLALACESGSGCLTNDLDENLGLLCAVKGKDEKWHRGFVECLPLNSQVKVVFVDSGYC 342

  Fly   209 ETEKANN-----------PVRSEASAPATSDNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQ 262
            |:.|..|           |:.:...:.:..:.|......|....:.||:..|:.:  |.:.:..:
Zfish   343 ESVKVENILQLPSEFLSRPIMAFPCSLSCLEKQDEDIKNQQVDALKTGLLGKVLE--IEIDDFRK 405

  Fly   263 LENPTEVTAASIEKVNKLPKSPRNRFLLPPKGGTETTRRDIYNQILKDMAAFPENTIVTAVLASV 327
            .:|...||....:|     .|.:...:.|.:.....:..:....:|.:::|..     |.|..:.
Zfish   406 DQNLYLVTMNIAQK-----HSEKQAGVKPHESDNLRSNSNFPYDVLSNVSAGE-----TKVAQTS 460

  Fly   328 DVTDNCA---------YVAK-------W--------------DESSDRIKKVLQRQLPLQELDQL 362
            |...|.|         ||..       |              .|.:|...|:   ||..:..:.|
Zfish   461 DSNPNRAIPDDSFFEGYVVHVQSPKHFWIRTKEHNPNFENMTKEMADYFSKL---QLHEEVFEDL 522

  Fly   363 PDYGDIFAVLDSINNIITRITINSSSAGGGYDAYLIDFGEHIHFDGNETIFKLPDDIKRLPAQAI 427
            .......|:.::.......:.:::...|.  :.:.||||......| ..|.|||......|..|:
Zfish   523 VPGALCCAMYENDMQYYRALVVDTLDKGA--EVFFIDFGNTEKVPG-ILIKKLPKKFAIHPEFAM 584

  Fly   428 RCDLINCDIANMHCFVNTYIKIRVHEN--------------NNSTLVAEPVIDRLSRPTKTNTTK 478
            .|.|.:               :..||:              ::.||:.. |:.|.:|       |
Zfish   585 ECALAH---------------VAPHEDIWTTTASNYFREVTSDKTLMIH-VVHRKNR-------K 626

  Fly   479 YPAGITEDDMAMLNEIDESTSDPLKAVLGFRPKDEQRICRHYDPKL------NGC-FKGNNC--- 533
            |...:.|.|....:.....|:  .|..|.:|          |:|.|      ..| :|||..
Zfish   627 YVVDLFERDAENCSIATIMTT--AKMALDWR----------YNPALASVEIERPCKYKGNALSKK 679

  Fly   534 ----------------------RFAHEPFAPNGATKDVELARALPETIFDTT---VHFEIGSIVG 573
                                  :..||....|...|........||.:...|   :||:.||.|.
Zfish   680 KNKKDLRVVTFHKVTSSMSSPNQIEHEWEPQNYLEKHTPSETLKPEVVPAKTLKPMHFKPGSEVS 744

  Fly   574 ILITFINGPTEVYGQFLDGSPPLVWDK--KDVPENKRTFKSKPRLLDIVLALYS--DGCFYRAQI 634
            ::.:.:|.|::.:.|  :.|..|..||  :::....:|:.|...:..:..|:.|  |..::||.:
Zfish   745 VICSHVNTPSDFWCQ--NVSTKLDLDKLMEEMQLFYQTYTSGLLMPALCCAVKSPHDNQWHRACM 807

  Fly   635 IDEFPSEYMIFYVDYGNTEFVPLSCLAPCENVDSFKPH---------RVFSFHIEGIVRSK---- 686
            |.:...:.::..||.|      |......:|:.:.:|.         |.....||.|..|.
Zfish   808 IGQHNEQLLMILVDVG------LIIQEKLQNIQTLQPQFLELPTQAFRCRLNFIEPIGGSSWSSE 866

  Fly   687 --NLTHQKTIECIE---------YLKSK-LLN--------TEMNVHLVQR-------LPDGFLIR 724
              ||......:|..         |.|.| |||        .:.:.:||::       .||...|.
Zfish   867 ACNLLRDFLFKCTSSKCRIYSQVYEKGKGLLNIVSIHTPLQQASTYLVEKGVAAEVQAPDKHTIS 931

  Fly   725 FLDDWKYI---------PEQLLQRNY 741
            ....|.::         .|:|:...|
Zfish   932 SAHPWSFVYSSFNISCGSEELVHVTY 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	25/123 (20%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	10/45 (22%)
tdrd15	NP_001182210.1	TUDOR	69..113	CDD:119391
		TUDOR	264..370	CDD:278965	18/109 (17%)
		TUDOR	306..352	CDD:119391	8/45 (18%)
		TUDOR	468..590	CDD:278965	24/127 (19%)
		TUDOR	525..571	CDD:119391	8/48 (17%)
		TUDOR	738..852	CDD:278965	25/121 (21%)
		TUDOR	945..1065	CDD:278965	3/13 (23%)
		TUDOR	999..1043	CDD:119391
		TUDOR	1227..1339	CDD:278965
		TUDOR	1274..1319	CDD:119391
		TUDOR	1618..1729	CDD:278965
		TUDOR	1661..1710	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000