DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and Snd1

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_073185.2	Gene:	Snd1 / 64635	RGDID:	631340	Length:	909	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	148/804 - (18%)
Similarity:	236/804 - (29%)	Gaps:	332/804 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 KNMEETMPSNPFHEQLEGSLEEIPVGSKIVVETEKANNPVR---SEASAPATSDNQSLLAAKQGT 239
            :|:.|::.:.....:.||.               :||||.:   ||....|.:..:.:.:...|:
  Rat   120 ENIAESLVAEGLASRREGM---------------RANNPEQNRLSECEEQAKASKKGMWSEGNGS 169

  Fly   240 QTIGTGICNKISKSTINMPNNWQLENPTEVTAASIEKVNK--------LP------------KSP 284
            .||      :..|.||..|.::...:..:...|.||.|..        ||            |.|
  Rat   170 HTI------RDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDHYLVTVMLSGIKCP 228

  Fly   285 RNR-----------FLLPPKGGTET--TRRDI-------YNQILKDMAAFPENTIVTAVLASVDV 329
            ..|           |....|..||:  .:||:       :||.:......|...|...:|
  Rat   229 TFRRETDGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLL----- 288

  Fly   330 TDNCAYVAKWD-----------ESSDRIKKVLQRQL--------PLQELDQLPDYGDIFAVLDSI 375
            .:..|....|.           .:::|..|  :|:|        |...||| .|...:..|:..:
  Rat   289 KEGFARCVDWSIAVYTRGAEKLRAAERFAK--ERRLRIWRDYVPPTANLDQ-KDKQFVAKVMQVL 350

  Fly   376 NNIITRITINSSSAGGGYDAYLIDFGEHIHFDGNETIFKLPDDIKRL-PAQAIRCDLINCDIANM 439
            |.....:.:||    |.|....:........:|:    .:.|..|:| |..         ||..|
  Rat   351 NADAIVVKLNS----GDYKTIHLSSIRPPRLEGD----NIQDKNKKLRPLY---------DIPYM 398

  Fly   440 HCFVNTYIKIRVHENNNSTLVAEPV---IDRLSRPTKTNTTKYPAGITEDDMAM-----LNEIDE 496
                     ....|.....|:.:.|   :|.: ||....|...|| .:|...|.     :|..:.
  Rat   399 ---------FEAREFLRKKLIGKKVSVTVDYI-RPASPATETVPA-FSERTCATVTIGGINIAEA 452

  Fly   497 STSDPLKAVLGFRPKDEQRICRHYDPKL--------NG--------------------------- 526
            ..|..|..|:.:|..|:|| ..|||..|        ||
  Rat   453 LVSKGLATVIRYRQDDDQR-SSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQF 516

  Fly   527 ----------------CFKGNNCRF------------------------------AHEPFAPNGA 545
                            .|.|:..:.                              ..|||:....
  Rat   517 LPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEAT 581

  Fly   546 --TKDVELAR---------------------------------ALPETIFDTT------------ 563
              ||::.|.|                                 ||.:..|...
  Rat   582 LFTKELVLQREVEVEVESMDKAGNFIGWLHMDGANLSVLLVEHALSKVHFTAERSAYYKPLLSAE 646

  Fly   564 -----------VHFE---IGSIVGIL-------------ITFINGPTEVYGQFLDGSPPLVWDKK 601
                       .|:|   :..::.:|             :|.|......|.|.::....|    :
  Rat   647 EAAKQRKEKVWAHYEEQPVEEVMPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGTQL----E 707

  Fly   602 DVPENKRTFKSK---------PRLLDIVLALYSDGCFYRAQIID-EFPSEYMIFYVDYGNTEFVP 656
            .:.||.|:..|.         ||..:..:|.:.||.:|||::.. |.|::..:||:||||.|.:|
  Rat   708 KLMENMRSDISSHPPVEGAYAPRRGEFCIAKFVDGEWYRARVEKVESPAKVHVFYIDYGNREILP 772

  Fly   657 ---LSCLAPCEN---VDSFKPHRVFSF------------HIEGIVRSKNLTHQKTIECIEYLKSK 703
               |..|.|..:   :.:......|:|            .::.:||....|     :|
  Rat   773 STRLGALPPAFSTRVLPAQATEYAFAFIQVPQDEDARTDAVDSVVRDIQNT-----QC------- 825

  Fly   704 LLNTEMNVHLVQRLPDGFLIRFLD 727
            |||.|   ||....|. ..::|.|
  Rat   826 LLNVE---HLSASCPH-VTLQFAD 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	33/151 (22%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	18/47 (38%)
Snd1	NP_073185.2	SNc	20..165	CDD:214615	11/59 (19%)
		SNc	25..165	CDD:238102	11/59 (19%)
		SNc	192..327	CDD:214615	26/141 (18%)
		SNc	200..327	CDD:238102	23/133 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	320..324		2/3 (67%)
		SNc	340..494	CDD:214615	39/182 (21%)
		SNc	349..495	CDD:238102	38/174 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	387..391		2/3 (67%)
		SNc	524..659	CDD:214615	12/134 (9%)
		SNc	532..659	CDD:238102	12/126 (10%)
		TUDOR	676..798	CDD:278965	30/125 (24%)
		TUDOR	727..783	CDD:197660	21/55 (38%)
		SNc	<843..894	CDD:294094	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810