DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and tdrd6

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	XP_694024.6	Gene:	tdrd6 / 565665	ZFINID:	ZDB-GENE-041001-210	Length:	2117	Species:	Danio rerio

Alignment Length:	845	Identity:	157/845 - (18%)
Similarity:	270/845 - (31%)	Gaps:	288/845 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MHQIHKELTEKLSHADLLYRSLIPLHDHLVASLSEVNAHVMKLNVQLHINRQSVRLGD------- 88
            :|.:...|......|.|.:..|:  .|.:      ::.||.......||    |:|.|
Zfish   593 LHGVKPRLKLWEERATLFFSKLV--RDRI------IDLHVQDKQQDTHI----VQLVDPSLDGEK 645

  Fly    89 ----------YEYYEKSIDNPYSSIRS-GLQAIEKPG-----------CAEAICQSSKPAFVECL 131
                      :...||||.: ||:.|| ||:.....|           |:.::...|..||.|.|
Zfish   646 DVSKLLCNAGFAVSEKSIVD-YSATRSCGLKTTHASGVFLTGTQPQTPCSSSVVMDSASAFKEYL 709

  Fly   132 -PSSTSEEVPVVAV--------QEASSTNQLDAISVVNENLSEERDATP---------------- 171
             |..:|.||.|..:        |:|.:...|:.:....:......:..|
Zfish   710 FPIGSSLEVTVSYIENPNDFWCQKARNAACLEVLMQDIQRFYSHSEFEPLLEAACVARHPETGIW 774

  Fly   172 -QPLAVSKN-------------------MEETMPSNPFHEQLEGSLEEIPVGSKIVVETEKANNP 216
             :.|.:.|:                   :|:.....|...:::|......:.:.|        :|
Zfish   775 YRALVIQKHQTPHVDVLFIDYGQTKKVAIEDLRKITPAFLKMKGQAFRCSLYNLI--------HP 831

  Fly   217 V---RSEASAPATSDNQSLLAAKQGTQTIGTGICNKISKSTINMP-----------------NNW 261
            |   .|:.|..||.:.|..:.|                .:::|:|                 |..
Zfish   832 VLHSSSDWSTEATLEFQEFVDA----------------AASMNVPLKCTIFAVMYDSQKVVFNVV 880

  Fly   262 QLENPTEVTAASIEKVNKLPKSPRNRFLLPPKGGTETTRRDIYNQILKDMAAFPENTIVTAVLAS 326
            .||.|.:.....:.:.....::|..|..|||      .|.|.|        .:..:.:.|.....
Zfish   881 DLETPFQSICNLLVQRRLADRAPSKRSPLPP------FRLDTY--------YYSTHGVKTGCDEK 931

  Fly   327 VDVTDNCA-----YVAKWDESSDRIKKVLQR------QLPLQELDQ------LPDYGDIFAVLDS 374
            |.:|  |.     :......:||.::|:.::      ||...:..|      ...|.|.......
Zfish   932 VSIT--CVKGVNQFFCHLARNSDEVEKLAEKVNFLCHQLEATKCPQTFGTVCFAKYTDGLWYRGQ 994

  Fly   375 INNIITRITINSSSAGGGYDAYLIDFGEHIHFDGNETIFKLP---DDIKRLPAQAIRCDL----- 431
            |.:....:.||           .:|:|:.:..|.:: :..:|   .||..:|.|||.|.|
Zfish   995 IKSTKPSVVIN-----------FVDYGDTLEVDKSD-LLPVPIEAGDIMSVPVQAIECGLSDMPE 1047

  Fly   432 -INCDI-------ANMHCF-----------------------VNTYIKIR----VHENNNSTLVA 461
             :.|::       |:.|||                       ||..||.:    :|:|:.||...
Zfish  1048 ELPCEVDNWFRKFADSHCFTALIVAKEPAGKLILELYDGKTQVNALIKQKFHNEIHKNDASTFKI 1112

  Fly   462 EPVIDRLSRPTKTNTTKYPAGITEDDMAMLNEIDESTSDPLKAVLGFRPK--DEQRICRHYD--- 521
            ..:..|.:...:.:..|                .||::.|.:..:...||  :...|.|..|
Zfish  1113 YGLKSRAAESVEASACK----------------KESSTGPKRDAIDQVPKSRESHAIQRSNDVAS 1161

  Fly   522 --PKLNGCFKG-------------NNCRFAHEPFAPNG------ATKDVELARALPETIFDTTVH 565
              |:....|..             |||:...|.....|      .:...|:.:..|:.:...:.
Zfish  1162 KQPQSRWGFSTNGRPEPTRDSGTINNCQKQPELRTSQGNLRHPCTSSKPEVVKPKPQALLKESA- 1225

  Fly   566 FEIGSI-----VGILITFINGPTEVYGQFLDGSPPLVWDKKDV---PENKRTFKSKPRLL----- 617
            ..|.||     ..:.|:..|.|...:.||       ..|:.|:   .|.....:|:.|.:
Zfish  1226 LPIKSIKPGLEAEVFISHCNSPCSFFVQF-------ATDEDDIYSLVEKLNADQSRCRNIDSSDI 1283

  Fly   618 ---DIVLALY-SDGCFYRAQIIDEFPSEYMIFYVDYGNTEFVPLSCLAPCENVDSFKPHRVFSFH 678
               |:|.|:: .|..:|||.:......:..:.:||:|||..:  |....|....||.....:|.|
Zfish  1284 HEGDLVCAMFPDDSSWYRAVVRKNTNEKIDVEFVDFGNTAVI--SSKNVCHLGQSFASFPRYSIH 1346

Fly 679 678
Zfish 1347 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	31/128 (24%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	13/44 (30%)
tdrd6	XP_694024.6	Tudor_SF	6..132	CDD:413384
		Tudor_TDRD6_rpt2	233..361	CDD:410492
		Tudor_SF	482..613	CDD:413384	4/19 (21%)
		Tudor_SF	705..828	CDD:413384	17/122 (14%)
		Tudor_SF	917..1042	CDD:413384	27/146 (18%)
		Tudor_SF	1238..1349	CDD:413384	28/118 (24%)
		Tudor_SF	1440..1579	CDD:413384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000