DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and Snd1

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_062750.2	Gene:	Snd1 / 56463	MGIID:	1929266	Length:	910	Species:	Mus musculus

Alignment Length:	773	Identity:	146/773 - (18%)
Similarity:	226/773 - (29%)	Gaps:	317/773 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 ETEKANNPVR---SEASAPATSDNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQLENPTEVT 270
            |..:||||.:   ||....|.:..:.:.:...|:.||      :..|.||..|.::...:..:..
Mouse   137 EGMRANNPEQNRLSECEEQAKASKKGMWSEGNGSHTI------RDLKYTIENPRHFVDSHHQKPV 195

  Fly   271 AASIEKVNK--------LP------------KSPRNR-----------FLLPPKGGTET--TRRD 302
            .|.||.|..        ||            |.|..|           |....|..||:  .:||
Mouse   196 NAIIEHVRDGSVVRALLLPGHHLVTVMLSGIKCPTFRRETDGSETPEPFAAEAKFFTESRLLQRD 260

  Fly   303 I-------YNQILKDMAAFPENTIVTAVLASVDVTDNCAYVAKWD-----------ESSDRIKKV 349
            :       :||.|......|...|...:|     .:..|....|.           .:::|..|
Mouse   261 VQIILESCHNQNLLGTILHPNGNITELLL-----KEGFARCVDWSIAVYTRGAEKLRAAERFAK- 319

  Fly   350 LQRQL--------PLQELDQLPDYGDIFAVLDSINNIITRITINSSSAGGGYDAYLIDFGEHIHF 406
             :|:|        |...||| .|...:..|:..:|.....:.:||    |.|....:........
Mouse   320 -ERRLRIWRDYVPPTANLDQ-KDKQFVAKVMQVLNADAIVVKLNS----GDYKTIHLSSIRPPRL 378

  Fly   407 DGNETIFKLPDDIKRL-PAQAIRCDLINCDIANMHCFVNTYIKIRVHENNNSTLVAEPV---IDR 467
            :|:    .:.|..|:| |..         ||..|         ....|.....|:.:.|   :|.
Mouse   379 EGD----NIQDKNKKLRPLY---------DIPYM---------FEAREFLRKKLIGKKVNVTVDY 421

  Fly   468 LSRPTKTNTTKYPAGITEDDMAM-----LNEIDESTSDPLKAVLGFRPKDEQRICRHYDPKL--- 524
            : ||....|...|| .:|...|.     :|..:...|..|..|:.:|..|:|| ..|||..|
Mouse   422 I-RPASPATETVPA-FSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQR-SSHYDELLAAE 483

  Fly   525 -----NG-------------------------------------------CFKGNNCRF------ 535
                 ||                                           .|.|:..:.
Mouse   484 ARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKET 548

  Fly   536 ------------------------AHEPFAPNGA--TKDVELAR--------------------- 553
                                    ..|||:....  ||::.|.|
Mouse   549 CLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHM 613

  Fly   554 ------------ALPETIFDTT-----------------------VHFE---IGSIVGIL----- 575
                        ||.:..|...                       .|:|   :..::.:|
Mouse   614 DGANLSVLLVEQALSKVHFTAERSAYYKPLLSAEEAAKQRKEKVWAHYEERPVEEVMPVLEEKER 678

  Fly   576 --------ITFINGPTEVYGQFLDGSPPLVWDKKDVPENKRTFKSK---------PRLLDIVLAL 623
                    :|.|......|.|.::....|    :.:.||.|...|.         ||..:..:|.
Mouse   679 SASYKPVFVTEITDDLHFYVQDVETGTQL----EKLMENMRNDISSHPPVEGSYAPRRGEFCIAK 739

  Fly   624 YSDGCFYRAQIID-EFPSEYMIFYVDYGNTEFVP---LSCLAPCEN---VDSFKPHRVFSF---- 677
            :.||.:|||::.. |.|::..:||:||||.|.:|   |..|.|..:   :.:......|:|
Mouse   740 FVDGEWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGTLPPAFSTRVLPAQATEYAFAFIQVP 804

  Fly   678 --------HIEGIVRSKNLTHQKTIECIEYLKSKLLNTEMNVHLVQRLPDGFLIRFLD 727
                    .::.:||....|     :|       |||.|   ||....|. ..::|.|
Mouse   805 QDEDARTDAVDSVVRDIQNT-----QC-------LLNVE---HLSASCPH-VTLQFAD 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	33/151 (22%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	18/47 (38%)
Snd1	NP_062750.2	SNc	21..166	CDD:214615	8/28 (29%)
		SNc	26..166	CDD:238102	8/28 (29%)
		SNc	193..328	CDD:214615	27/141 (19%)
		SNc	201..328	CDD:238102	24/133 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	321..325		2/3 (67%)
		SNc	341..495	CDD:214615	39/182 (21%)
		SNc	350..496	CDD:238102	38/174 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	388..392		2/3 (67%)
		SNc	525..660	CDD:214615	12/134 (9%)
		SNc	533..660	CDD:238102	12/126 (10%)
		TUDOR	677..799	CDD:278965	30/125 (24%)
		TUDOR	728..784	CDD:197660	21/55 (38%)
		SNc	<844..895	CDD:294094	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810