DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and TDRD1

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001372292.1	Gene:	TDRD1 / 56165	HGNCID:	11712	Length:	1189	Species:	Homo sapiens

Alignment Length:	996	Identity:	187/996 - (18%)
Similarity:	322/996 - (32%)	Gaps:	388/996 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SMIMKLFDSNMHKLQGNLRSYQTEMHQIH----------KEL---TEKLSHADL----------- 47
            |::.:....|.|||: |..|.:|:..:::          ||:   .|::..:||
Human   203 SIVCRPVQPNFHKLE-NKSSIETKDVEVNNKSDCPLGVTKEIAIWAERIMFSDLRSLQLKKTMEI 266

  Fly    48 ----------------LYRS-LIPLHDHLVASLSE--VNAH------------------------ 69
                            ||.| ::...:.|.|||.|  .|.|
Human   267 KGTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNR 331

  Fly    70 --VMKLNVQ------LHI---NRQSVRLGDYEYYEKSID-NPYSSIRSGL-QAIEKPGCAEAIC- 120
              :..::||      |:|   |.:.:.|....:..::|| .|..:|:..: ..|...|...:.|
Human   332 AIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCI 396

  Fly   121 QSSKPAFVECLPSSTSEEVPVVAVQEASSTNQLDAISVVNENLSEERDATPQPLAVSKNMEETMP 185
            :::||..:|                      |..:|.:| :.|.||        .|:..:|..:|
Human   397 KATKPLLME----------------------QYCSIKIV-DILEEE--------VVTFAVEVELP 430

  Fly   186 SNPFHEQLEGSLEEIPVGSKIVVETEKANNPVRS--EASAPATSDN-----QSLLAAKQGTQTIG 243
            ::  .:.|:..|.|:..|.|...:..|..|..:|  |.....|::|     :|.|..|..|..:|
Human   431 NS--GKLLDHVLIEMGYGLKPSGQDSKKENADQSDPEDVGKMTTENNIVVDKSDLIPKVLTLNVG 493

  Fly   244 TGICNKISKSTINMPNNW---QLENPTEVT--AASIEK-VNKLPKSPRNRFLLPPKGG---TETT 299
            ...|..::.  |..|.::   ||::..::.  .||:.| .::||  ||:.| .|..|.   .:.:
Human   494 DEFCGVVAH--IQTPEDFFCQQLQSGRKLAELQASLSKYCDQLP--PRSDF-YPAIGDICCAQFS 553

  Fly   300 RRDIYN-----------------------QILKDMAAFP-------------------------- 315
            ..|.:.                       :||..|...|
Human   554 EDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGI 618

  Fly   316 -------------ENTIVTAVLASVDVTDNCAYVAKWDES------------------------S 343
                         :|.|:|..:  ||..:|.:.|...|:|                        :
Human   619 WTPEAICLMKKLVQNKIITVKV--VDKLENSSLVELIDKSETPHVSVSKVLLDAGFAVGEQSMVT 681

  Fly   344 DRIKKVLQRQLPL-------------QEL--DQLPD------YG-----------DIFAVLDSIN 376
            |:...|.:..:||             .||  ||..|      |.           |....|:.:|
Human   682 DKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLN 746

  Fly   377 NIIT------------------------------RITINSSSAGGGYDAYLIDFGEHIHFDGNET 411
            ..:.                              |..:......|....:.:|:|.......:|
Human   747 KSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADE- 810

  Fly   412 IFKLPDDIKRLPAQAIRCDLINCDIANMH-----------CFVNTYIKIRVHENNNSTLVAEPVI 465
            :..:......||.|.|||.|.:....|.|           |.....::.||.|...:.:..|  :
Human   811 LRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIGVE--L 873

  Fly   466 DRLSRPTKTNTTKYPAGITE---DDMAMLNEIDESTSDPLKAVLGFRPKDEQRICRHYDPKLNGC 527
            ..||       |.||..|::   |:..:|     .::.|.|.:    |.|  |:...::.:::
Human   874 TDLS-------TCYPRIISDVLIDEHLVL-----KSASPHKDL----PND--RLVNKHELQVH-- 918

  Fly   528 FKGNNCRFAHEPFAPNGATKDVELARALPETIFDTTVHFEIGSIVGILITFINGPTEVYGQFLDG 592
            .:|.....:.|.:      |.:||.       .|.|:...:..|:
Human   919 VQGLQATSSAEQW------KTIELP-------VDKTIQANVLEII-------------------- 950

  Fly   593 SPPLVWD-KKDVPENKRTF--------------KS----KPRLLDIVLALY-SDGCFYRAQIIDE 637
            ||.|.:. .|.:|||:...              ||    :||:.|...|.| ||..:|||.::..
Human   951 SPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGT 1015

  Fly   638 FPSEYMIFYVDYGNTEFVPLSCLAPCENVDSFKPHRVFSFHIEGIVRSKNLTHQKTIECIEYLKS 702
            ..::..:.|.||||.|.:||..:.|..:.....|.::....:||::.....:.|.   .|..||:
Human  1016 SDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQL---IIMLLKN 1077

  Fly   703 KLLNTEM---------NVHLV 714
            .:||..:         |||.|
Human  1078 FMLNQNVMLSVKGITKNVHTV 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	30/130 (23%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	16/44 (36%)
TDRD1	NP_001372292.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..138
		zf-MYND	170..206	CDD:396356	1/2 (50%)
		Tudor_TDRD1_rpt1	268..396	CDD:410479	22/127 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..469		4/18 (22%)
		Tudor_TDRD1_rpt2	517..598	CDD:410480	15/83 (18%)
		TUDOR	715..832	CDD:395449	17/117 (15%)
		Tudor_TDRD1_rpt4	944..1059	CDD:410482	30/134 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910