DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and tdrd1

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	XP_021335784.1	Gene:	tdrd1 / 553522	ZFINID:	ZDB-GENE-070803-1	Length:	1201	Species:	Danio rerio

Alignment Length:	695	Identity:	132/695 - (18%)
Similarity:	242/695 - (34%)	Gaps:	185/695 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 NQLDAISVVNENLSEERDAT-PQPLAVSKNMEETMPSNP----FHEQLEGSLEEIPVGSKIVVET 210
            |...|..::..||...|.|| |..|:         |..|    :.|:|..|  ::..|.||....
Zfish     2 NPAFAQPMMRPNLPLRRPATGPSSLS---------PRGPAPAIYEERLLAS--DVLDGPKIDTMR 55

  Fly   211 EKANNPVRSEASAPATSDNQSLLAAK-------QGTQTIGTGICNKISK----STINMPNNWQLE 264
            :..:.......|:|.|:.:......|       ||...     |.:..|    |......:|...
Zfish    56 KDISQNCGDVLSSPQTAVSMMGQVVKLCNYCSHQGNLR-----CTRCKKTCYCSVACQTQDWIAH 115

  Fly   265 NPTEVTAASIEKVNKLPKSPRNRFLLP---PKGGTETT------------RRDIYNQIL------ 308
            .  .|...||.:|..  :.|:....:|   ..|||:..            |||::.:::
Zfish   116 R--HVCKPSIPEVTS--EKPKESKAVPYANGLGGTQAKEISVDAQPKRIYRRDLHKKVVSKGSEI 176

  Fly   309 -------KDMAAFPE-NTIVTAVLASVDVTD---------NCAYVAKWDESSDRIKKVLQRQLPL 356
                   ..:..:|. :|:.........|.|         :|    :.:|..:.:||:.|:   |
Zfish   177 KVLFFRCSSLVCYPSIDTLPHTKCLQGTVIDLRNPGMFSIHC----QCEEMIESLKKITQQ---L 234

  Fly   357 QEL-------DQLPDYGDIFAVLDSINN-----IITRITINSSSAGGGYDAYLIDFG--EHIHFD 407
            |:.       :..|:.|::.||..|::.     .|..:.:...:||    .:.||||  |::..|
Zfish   235 QKTYCSSFAQEYKPEVGELCAVKFSLDQNWYRAEIQAVDVARKTAG----VFYIDFGNEENVALD 295

  Fly   408 GNETIFKLPDDIKRLPAQAIRCDLI-----------NCDIANMHCFVNTYIKIRVHE--NNNSTL 459
               .|..|.::|..:|..|::|.:.           .|.||.........:...|.:  |:...|
Zfish   296 ---HIRPLSENIDAVPPFALQCCIAGVKPLTGSWTGECCIAVRQLIAGKSLTFTVLDIMNDGDLL 357

  Fly   460 VAEPVIDRLSRPTKTNTTKYPAGITEDDMAMLNEIDESTSDPLKAVL-GFR----PKDEQRICRH 519
            ..:.::..|.:...|........|.| |:.:..:.:.|.:..|.|.. .|:    .|:|....|.
Zfish   358 AVDSLVSTLGKHVSTFLIDQSYAIKE-DVPVKTQTEHSINSLLTASFENFKRFSGGKNENSEARP 421

  Fly   520 YDPKLNGCFKGNNCRFAHEPFAPNGATKDVELARALPETIFDTTVHFEIGSIVGILITFINGPTE 584
            .:|...|                                         :|.....::|.:..|:|
Zfish   422 PEPLTQG-----------------------------------------VGDSFTAVVTHLQSPSE 445

  Fly   585 VYGQFLDGSPPLVWDKKDVPENKRTFKSKPRLLD--------IVLALYS-DGCFYRAQIIDEFPS 640
            :..|.|:.:..:    :.:..|.|...|.....|        :..:|:| |..:|||::: .:.|
Zfish   446 ILCQKLENASII----QQLQMNLRVHCSNTAASDDFRPAPGTVCCSLFSEDNQWYRAKVL-AYSS 505

  Fly   641 E--YMIFYVDYGNTEFVPLSCLAPCENVDSFKPHRVFSFHIEGIVRSKNLTHQKTIECIEYLKSK 703
            |  ..:.|:|:||:|.|.|:.|.|..........:.....:.||   |:||...:.|.:..||..
Zfish   506 EDRVCVGYIDFGNSEEVELNRLRPISKELLALATQAIPCSLAGI---KSLTDTWSDEAVLMLKHL 567

  Fly   704 LLNTEMNVHLVQRLPDGFLIRFLDD----WKYIPEQLLQRNYAQV 744
            :.|..:.|.::.:.....|:..:|:    ...:.|.|:...:|.:
Zfish   568 VCNRFIRVEILGKKDGRALVSMIDESSDPQASVTELLVNMGFAAI 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	27/121 (22%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	17/54 (31%)
tdrd1	XP_021335784.1	zf-MYND	83..119	CDD:307734	6/42 (14%)
		TUDOR	210..318	CDD:306940	27/121 (22%)
		TUDOR	429..548	CDD:306940	27/123 (22%)
		TUDOR	652..770	CDD:306940
		TUDOR	908..1020	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000