DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and tdrd7

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001011355.2	Gene:	tdrd7 / 496822	XenbaseID:	XB-GENE-944683	Length:	1088	Species:	Xenopus tropicalis

Alignment Length:	979	Identity:	171/979 - (17%)
Similarity:	300/979 - (30%)	Gaps:	360/979 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DISMIMKLFDSNMHKLQGNLRSYQTEMHQIHKELTEK------------LSHADLLYRSLIPLHD 57
            |:|:|.......::|....|  :.:::.|::||..::            .:|..::.:.:...|.
Frog   231 DLSVIQNNLKELLNKHSNGL--WLSKLPQLYKETYKQDLGGEMLKQVPSWTHICMVQKLVTMGHT 293

  Fly    58 HLVASLSEVNAHVMKLNVQLHINRQ------------------SVRLGDYEYYEKSIDNPYSSIR 104
            .:|...:.:.......|||.|.|.|                  |..:...|..:| |....:...
Frog   294 EMVLYSTAIKQPSFTKNVQNHSNNQAKPNVPVDSTPSSPPLQSSGNIPKDELKQK-ISKVLTKYS 357

  Fly   105 SGLQAIEKPGCAEAICQSSKPAFVECLPSST--------SEEVPVVAVQEASSTNQLDAIS--VV 159
            :||.....|...|.:.:...|..|..|.|.|        ||| |..|:..|.|..:.:..|  .|
Frog   358 NGLWYHALPKVFEDMFKQKLPTEVLNLDSLTDICTVDLISEE-PFKAILYAKSAERANQNSNPSV 421

  Fly   160 NENLSE--------------ERDATPQPLAVSKNMEETMPSNPFHEQLEGSLEEIPVGSKIVVET 210
            |.|:.:              |.:.||.||.:        ||           |..|  |.:|||.
Frog   422 NNNIPQKLQDRESPLLPEEPEMNMTPPPLVI--------PS-----------EASP--SVLVVEL 465

  Fly   211 EKANNPV-----RSEASAPATSDNQ------SLLAAKQGTQTIGTGICNKISKSTINMPNNWQLE 264
            ...|:.|     |..::|....:::      ....||.|...:|..:..|..:..      |...
Frog   466 SSTNDVVIRYIGRDYSAAQEHMEDEMKDFCSKSSTAKIGFLRVGQLVAAKAEEDV------WLRA 524

  Fly   265 NPTEVTA---------------ASIEKVNKLPKSPRNRFLLPPKGGTETTRRDIYNQILKDMAAF 314
            ..:.:..               ..|.||.||.|    :|...|...|:..        |..:.||
Frog   525 QISAIEGKKVKVCYVDYGFSEIVDITKVCKLGK----QFYTLPFQATKCR--------LAGLEAF 577

  Fly   315 PENTIVTAVL--------ASVDVTDNC--AYVAKWDESSDR--------IKKVLQRQLPLQ---- 357
            .:::|:...|        .:|::.:..  ..|..:|.|.|.        :|::..|.|.||
Frog   578 CDDSIIIKALELKACGKILAVEILEKSEKPLVVLYDTSGDDDININAACLKELCDRSLSLQLKAN 642

  Fly   358 ----------------ELDQLPDYG--DIFAVLDSINNII------------------------- 379
                            ...|||..|  .::..|..:::..
Frog   643 SSFSNVIVTNVCSDGTLFCQLPSKGLAKLYETLQKVDSEFQSKQVTSHLYVSLPFCGKICLYHYK 707

  Fly   380 ---TRITINSSSAGGGYDAYLIDFGEHIHFDGNETIFKLPD----DIKRLPAQAIRCDL------ 431
               .|:.|.|..:....|...:|.|.......:| :.::|.    |:..:|.||:||.|
Frog   708 GKWARVEITSVHSSRALDVQFLDSGTIASVKVSE-LKEIPPPLLRDLISIPPQALRCCLADLPLR 771

  Fly   432 ----------------INCDIANMHCFVNTYIKIRVHENNNS------TLVAEPVIDRLSRPTKT 474
                            :||    :.|.:..   ::|.|..|.      |....|.::|......|
Frog   772 IGMWTPDAVLWLRNTVLNC----LECSIRV---VKVDEATNMVHIYLFTSNNFPDLERSINRQIT 829

  Fly   475 NTTKY-----------------------------PAGITEDDMAMLNEIDESTSDPLKAVLGFRP 510
            |...:                             |.|:.:|..:.:.:.|...|..:.:.....|
Frog   830 NEELWKHQKDVFLNLSASTLESSRGGGAQASELSPPGLCKDHTSAVKKPDMQQSSSVPSFNMPPP 894

  Fly   511 KDEQRICRHYDPKLN-GCFKGNNCRFAHEPFAPNGATKDVELARALPETIFDTTVHFEIGSIVGI 574
            ....|...|.|..:: .|..|:   |..:|:.        ||.: |...:.:..:|:
Frog   895 LPLPRPGEHMDVFVSVACHPGH---FVCQPWQ--------ELHK-LEVVMEEMLLHY-------- 939

  Fly   575 LITFINGPTEVYGQFLDGSPPLVWDKKDV----PENKRTFKSKPRLLDIVLALYSDGCFYRAQII 635
                  ..||        ..|:..:|..:    .|||                     :||..:.
Frog   940 ------STTE--------EKPVALEKNKLYAAKVENK---------------------WYRVLVK 969

  Fly   636 DEFPSEYM-IFYVDYGNTEFVPLSCLAPCENVDSFK--PHRVFSFHIEGIVRSKNLTHQKTIECI 697
            ....:..: ::.:|||..|.|  ||......::.|.  |.:..:..:.| |..::.:.:.:|...
Frog   970 GILTNGLVSVYELDYGRHELV--SCRKVQPLIEKFMQLPFQAITSQLAG-VSCEHWSEEASIVFR 1031

  Fly   698 EYLKSKLLNTEMNVHLVQ--------------------RLPDGFLIRFLDDWKYIPEQLLQRNYA 742
            .:::.|.|     |.|||                    .|||      .|.|.:   :|:...:.
Frog  1032 NHVEKKPL-----VALVQTIHESTHPWDRRAVAYIVDTSLPD------TDIWIH---ELMTEYHI 1082

  Fly   743 QVSQ 746
            |:|:
Frog  1083 QLSK 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	18/117 (15%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	9/44 (20%)
tdrd7	NP_001011355.2	LabA_like_C	7..93	CDD:387402
		LabA_like_C	232..298	CDD:387402	10/67 (15%)
		LOTUS_3_TDRD7	342..407	CDD:193588	17/66 (26%)
		TUDOR	459..572	CDD:366171	23/130 (18%)
		TUDOR	647..766	CDD:366171	19/119 (16%)
		TUDOR	905..1015	CDD:366171	27/166 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100