DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and CG9925

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_650324.1	Gene:	CG9925 / 41702	FlyBaseID:	FBgn0038191	Length:	892	Species:	Drosophila melanogaster

Alignment Length:	802	Identity:	152/802 - (18%)
Similarity:	248/802 - (30%)	Gaps:	296/802 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HADLLYRSLIPLHDHLVASLSEVNAHV-------------------MKLNVQLHIN--------- 80
            |..|..:.:|||  .|...:.::|..|                   :::||..|:|
  Fly   251 HVHLKPKMIIPL--SLPLEMLQLNPEVKVIRVFKANPKHNEPQLALLQINVMGHVNADLNNRIAE 313

  Fly    81 --RQSVRLGDYEYYEKSIDNPYSSIRSG------LQAIEKPGCAEAICQSSKPAFVECLPSSTSE 137
              ||...|...|  :|||....:..::|      |..|.||          :|.::
  Fly   314 KPRQPFTLPFPE--QKSIFFAATRTKNGYRRAFLLDHIMKP----------RPTYL--------- 357

  Fly   138 EVPVVAVQEASSTNQLDAISVVNENLSEERDATPQPLAVSKNMEETMPSNPFHEQLEGSL-EEIP 201
               |..:.|...:...|...:.:|.|.                   :||..|..|||.|: ||:.
  Fly   358 ---VYEMDEGRVSIATDLSRIPSELLG-------------------LPSRVFAAQLEDSVPEELE 400

  Fly   202 V-GSKIVVETEKANNPVRSEASAPATSDNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQLEN 265
            . |:::.|:.:..|.|.:           :.|.||.....:.|..||
  Fly   401 TQGAELTVKFKLDNKPPK-----------EKLRAANAALNSKGEQIC------------------ 436

  Fly   266 PTEVTAASIEKVNKLPKSPRNRFLLPPKGGTETTRRDIYNQ---ILKDMAAFPENTIVT------ 321
                .|..|..:.::      .:|     |.:..|..|.:.   .:..:.:|.|..|.|
  Fly   437 ----MARLITFLGQI------SYL-----GHKYWREPIVHDSIVFISHLVSFKEVYISTPDAKQY 486

  Fly   322 -AVLASVDVTDNCAYVAK-WDESSDRIKKVLQRQLPLQELDQLPDYGDIFAVLDSINNIITRITI 384
             .:...::.  .||.:.| .|.|...|..|:.:|:.....:.|.....:|.|:    |:.|
  Fly   487 AEIFKRLEY--KCATITKSSDVSVGSIVLVVSKQMGHFRGEILSKDSGLFEVM----NVDT---- 541

  Fly   385 NSSSAGGGYDAYLIDFGEHIHFDGNETIFKLPDDIKRLPAQAIRCDL-------INCDIANMH-- 440
                 |......|.:......|..|     ||..:.|:..|.: |::       .|..|..:|
  Fly   542 -----GATQKVELAEIRSSCRFLEN-----LPVCLMRVQLQNV-CNIPDAAVPVNNAAIQMLHKL 595

  Fly   441 CFVNTYIKIRVHENNNST-------------------LVAEPVIDRLS-RPTKTNTT-------- 477
            |.....:|:.:.:...||                   |:..||.::.. .|.|..:|
  Fly   596 CAQKELLKLNMVDATTSTVDLLFSSGDSRSLTTQMLPLIFTPVQEKAEVAPPKAASTPSQLPVVT 660

  Fly   478 --------------------------KYPAGITEDDMAMLNEIDESTSDPLKAVLGFRPKDEQRI 516
                                      .:||.:|....|       |...|:|..|
  Fly   661 HKQQKVSPQSLLLLDLPPLPPSPPESPFPADVTSTKSA-------SHVLPIKRFL---------- 708

  Fly   517 CRHYD--PKLNGCFKGNNCRFAHEPFAPNGATKDVELARA--LPETIFDTTVHF-------EIGS 570
               :|  ||               ..||.|...::.|..|  ||:|.:.|..:|       |...
  Fly   709 ---FDALPK---------------NLAPLGDKVNLILMNADGLPQTGYITAAYFKDEKAAKEFEK 755

  Fly   571 IVGILITFINGPTEVYGQFLDGSPPLVWDKKDVPENKRTFKSKPRLLDIVLALYS-DGCFYRAQI 634
            |:.:        |...|         ..|...||      ...|.:.::.||:|| |..:||...
  Fly   756 ILSL--------TSSQG---------ACDHNVVP------GYVPNVGELCLAIYSEDKNWYRGVC 797

  Fly   635 IDEFPSEYMIFYVDYGNTEFVPLSCLAPCENVDSFKPHRVFSFHIEGIVRSKNLT--HQKTIECI 697
            .:...:...|.:.|:||||:|.:..:.|... |......|...:|.|..:|||..  .|..:..|
  Fly   798 QEVKDNMVKILFCDFGNTEYVAVRHVKPISQ-DLLIAVNVTKCYINGFDKSKNFAALEQFLVRKI 861

  Fly   698 EYLKSKLLNTEMNVHLVQRLPD 719
            .:|.......|.:..|: .:||
  Fly   862 RFLCGVKKGPEPDTRLI-TIPD 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	24/111 (22%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	14/44 (32%)
CG9925	NP_650324.1	zf-MYND	9..44	CDD:280009
		TUDOR	109..225	CDD:278965
		TUDOR	457..573	CDD:278965	25/135 (19%)
		TUDOR	718..843	CDD:278965	35/148 (24%)
		TUDOR	779..825	CDD:119391	14/45 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100